Abstract:
:Perfluoroctylbromide (PFOB), a radiopaque reticuloendothelial system contrast media for computed tomography, has been shown to accumulate in macrophages. In the current study PFOB was tested in rabbits as an abscess imaging agent. Two abscesses were induced in each of 24 rabbits, one in the liver and the other in the peritoneal cavity. CT of the rabbit abdomen was performed four days later, two days after the administration of 5 gm/Kg of PFOB to 12 of these rabbits. The average enhancement of the wall of liver abscesses was by 140 Hounsfield units (HU) relative to the enhanced liver and peritoneal abscesses by 135 HU relative to the control group. This enhancement was secondary to the intense accumulation of PFOB filled macrophages in the abscess wall. In those rabbits where the liver abscess ruptured, the edges of the peritoneal collections enhanced by 147 HU. Regions of inflammation prior to liquifaction enhanced considerably. These areas could not be detected in the animals not receiving PFOB. Though the liquified center of liver abscesses could be seen in the absence of PFOB, none of the peritoneal abscesses could be detected in the animals not receiving PFOB. In contradistinction, all peritoneal abscesses enhanced considerably following PFOB allowing their prospective localization. In conclusion, PFOB accumulates in abscess walls and areas of inflammation producing marked CT enhancement of liver and peritoneal abscess collections. This enhancement allowed the differentiation of peritoneal abscess collections from adjacent bowel.
journal_name
Invest Radioljournal_title
Investigative radiologyauthors
Mattrey RF,Andrè M,Campbell J,Mitten R,Multer F,Hackney D,Long DM,Higgins CBdoi
10.1097/00004424-198409000-00017subject
Has Abstractpub_date
1984-09-01 00:00:00pages
438-46issue
5eissn
0020-9996issn
1536-0210journal_volume
19pub_type
杂志文章abstract::The purpose of our investigation was to determine whether iopanoyl glucuronide, the major metabolite of iopanoic acid (Telepaque), undergoes hydrolysis by bacterial beta-glucuronidase in dogs. The conjugated compound was identified and quantitated by elemental analysis, fluorescent excitation analysis, thin-layer chro...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197805000-00011
更新日期:1978-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was to assess the value of intravoxel incoherent motion and diffusion-weighted imaging for predicting the histologic grade of pancreatic neuroendocrine tumors (PNETs). MATERIALS AND METHODS:Forty patients with surgically diagnosed PNETs who underwent preoperative magnetic resonance im...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000028
更新日期:2014-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors synthesized and tested a novel hydrogel system proposed for use in extra- and intravascular radiologic interventions, such as chemoembolizations and embolizations, and as a vehicle for sustained drug release. MATERIALS:The material was specifically designed to meet the prerequisite...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199312000-00001
更新日期:1993-12-01 00:00:00
abstract:PURPOSE:Detection of pulmonary metastases is still a challenging task for magnetic resonance imaging (MRI). It was the aim of this study to evaluate the potential of a free-breathing move-during-scan turbo inversion recovery magnitude sequence for the detection of pulmonary nodules. MATERIALS AND METHODS:The sensitivi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31816901fa
更新日期:2008-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Iopromide is a new monomeric, nonionic contrast agent that exhibits low osmolality and low viscosity in high concentration in aqueous solutions. Double-blind, randomized clinical trials have established the efficacy, safety, and tolerance of iopromide for excretory urography, coronary angiograp...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00004424-199405001-00015
更新日期:1994-05-01 00:00:00
abstract::Percutaneous injection of absolute ethanol into adenocarcinomas implanted in the hind leg of rats was evaluated as a potential cancer treatment. Intramuscular alcohol injections up to 10 mL/kg produced a local dose-dependent coagulation necrosis followed by granulation tissue formation and subsequent fibrosis but no a...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198706000-00005
更新日期:1987-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The efficacy of gadoteridol for contrast enhancement of central nervous system pathology was assessed in a multicenter clinical trial involving 411 patients suspected of having intracranial or spinal pathology. METHODS:Magnetic resonance imaging was performed before and after intravenous admin...
journal_title:Investigative radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:1992-08-01 00:00:00
abstract::Observer performance in radiologic interpretation has traditionally been based upon Receiver Operating Characteristic (ROC) analysis. A statistical method that evaluates the reproducibility or consistency of radiologic interpretation is presented. Since this method is not based upon pathologic verification, it cannot ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198411000-00024
更新日期:1984-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Air microemboli may damage the cerebral microvasculature. The aim of this study was to evaluate the safety of ultrasound contrast agents composed of air microspheres with regard to cerebral damage when administered into the arterial system (ie, when not filtered by the capillary system of the l...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199803000-00001
更新日期:1998-03-01 00:00:00
abstract::Gallbladder sclerotherapy after permanent cystic duct occlusion, to prevent gallstone recurrence in nonsurgical gallstone therapy, is at least a two-stage procedure. A balloon catheter was developed to perform gallbladder sclerotherapy with only temporary occlusion of the cystic duct, and the efficacy and safety of th...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199109000-00005
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVES:: To evaluate the performance of a gadolinium-based contrast compound (P846) as well as an ultra-small particle of iron oxide agent (P904) in contrast-enhanced magnetic resonance angiography (MRA) in rabbits and to compare those agents with gadoterate meglumine (Gd-DOTA) for first pass and steady state imagi...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e31821ae21f
更新日期:2011-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To compare technical aspects and neointima formation of a new Nitinol stent and a Wallstent. METHODS:A Nitinol sten and a Wallstent were placed into the iliac arteries of 14 sheep (total of 28 stents) and followed angiographically. Seven sheep were killed after 1 month and 7 after 4.5 months. ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199507000-00004
更新日期:1995-07-01 00:00:00
abstract::Because of the strong scientific evidence in support of radiation hormesis, we can no longer ignore this concept. There is, however, need for additional, carefully documented investigations in selected biological systems exposed to LLIR if the matter of radiation hormesis is to be settled once and for all. This need s...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the feasibility of nonenhanced magnetic resonance angiography (MRA) of the lower extremities at 7 tesla (T). MATERIALS AND METHODS:Eight healthy volunteers were examined on a 7-T whole-body magnetic resonance system. For image acquisition, a custom-built 16-channel t...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e3182839c2b
更新日期:2013-07-01 00:00:00
abstract::The hardcopy recording technologies of video cameras, slow-scan (digital spot) recorders, and laser film printers are presented and compared. Slow-scan (digital spot) recorders offer a few advantages when compared with multiformat video cameras. But only laser film printers provide the high-quality hardcopy recordings...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199102000-00017
更新日期:1991-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:As part of a general examination of the effect of blood flow patterns on the growth and risk of rupture of abdominal aortic aneurysms, the authors investigated the flow through an experimental model of a fusiform aneurysm. MATERIALS AND METHODS:Aneurysms were simulated in polyvinyl chloride tu...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199207000-00008
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess quantitative ultra-high b-value (UHB) diffusion magnetic resonance imaging (MRI)-derived parameters in comparison to standard clinical apparent diffusion coefficient (SD-ADC-2b-1000, SD-ADC-2b-1500) for the prediction of clinically significant prostate cancer, defined as G...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0000000000000712
更新日期:2021-02-01 00:00:00
abstract::We have examined the effect of dose on contrast medium-induced reductions in glomerular filtration in anesthetized rabbits. The fraction of renal plasma flow that is filtered, the filtration fraction, was directly measured by the renal arteriovenous difference method using technetium-99m (99mTc) (Sn) DTPA as the trace...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198309000-00007
更新日期:1983-09-01 00:00:00
abstract::Flow measurements can be made with computed tomography (CT) scanners using iodinated, nonionic contrast media as a first-pass indicator. Ultrafast CT (UFCT) is an ideal machine to make these measurements because of its short scan time (50 mseconds) and interscan delay (< or = 0.6 seconds). Additionally, UFCT can acqui...
journal_title:Investigative radiology
pub_type: 杂志文章,评审
doi:10.1097/00004424-199212002-00004
更新日期:1992-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The vasoconstriction of the renal arteries is frequently considered as a crucial factor for radiocontrast-induced nephropathy. A direct effect of iodinated radiographic contrast medium (RCM) on vascular smooth muscle is supposed to be one component of the vascular response. We studied the effec...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200208000-00005
更新日期:2002-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To analyze changes in Doppler ultrasound variables of the portal vein in relation to liver biopsy findings, the authors performed a prospective study of 316 Doppler ultrasound examinations in the first 2 weeks after orthotopic liver transplantation on 23 patients. METHODS:Recordings were obtai...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199612000-00007
更新日期:1996-12-01 00:00:00
abstract::Because of a need to correlate pulmonary microvascular changes with physiologic data during lung injury, in vitro and in vivo pulmonary capillary microangiography was performed on normal dogs and those subjected to oleic acid injury and glass bead microembolization. During these studies, no significant differences wer...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::An isotopic radiation source 125I was investigated for use in soft tissue radiaography, with particular attention to possible use in mammography for mass screening. Film sensitivities, exposure rates, absorbed doeses, contrast and resolution were determined, and compared to conventional x-ray units. It was found that ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-197509000-00007
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVES:Intra-arterial digital subtraction angiography (IA-DSA), an invasive procedure, is the current reference examination after percutaneous transluminal angioplasty and stenting for the detection of in-stent restenosis (ISR). In this phantom study, we evaluated flat-panel angiographic computed tomography after i...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/RLI.0b013e318276db43
更新日期:2013-02-01 00:00:00
abstract::Thoracic metastases from squamous carcinoma and adenocarcinoma of the cervix were studied by reviewing 245 consecutive cases to describe comparative incidence, natural history, and radiographic patterns. The incidence of chest metastases was higher for adenocarcinoma (20%) than for squamous carcinoma (4%). Few patient...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198003000-00004
更新日期:1980-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Diabetic patients frequently suffer contrast media-induced nephropathy. Hyperglycemia in diabetes mellitus causes gradual deterioration of glomerular mesangial cells (MCs) in the kidney. In this study, the authors investigated the response of rat MCs cultured in high-glucose medium to diatrizoa...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-200107000-00001
更新日期:2001-07-01 00:00:00
abstract::The rates at which the paramagnetic compounds deoxyhemoglobin (Hb) and methemoglobin (MHb) form in vivo within an area of hemorrhage are unknown. The present experiment establishes the baseline concentrations and rates of change in paramagnetic hemoglobin concentrations, as well as the pH in normal heparinized and clo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199003000-00006
更新日期:1990-03-01 00:00:00
abstract::Dense cavitary "photopenia" was observed on 21 of 200 consecutive stress perfusion scintigrams. A prominent finding in many cases, it sometimes occupied only a portion of the region overlying the ventricular cavity, was often seen in some projections and not others, and was frequently adjacent to myocardial perfusion ...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-198507000-00009
更新日期:1985-07-01 00:00:00
abstract:PURPOSE:To prospectively determine the accuracy of 1.5 Tesla (T) and 3 T magnetic resonance angiography (MRA) versus digital subtraction angiography (DSA) in the depiction of infrageniculate arteries in patients with symptomatic peripheral arterial disease. PATIENTS AND METHODS:A prospective 1.5 T, 3 T MRA, and DSA co...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/01.rli.0000262581.52315.ef
更新日期:2007-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate image mottle in conventional CT images of the abdomen as a function of radiographic technique factors and patient size. METHODS:Water-filled phantoms simulating the abdomens of adult (32 cm in diameter) and pediatric (16 cm in diameter) patients were used to investigate image mo...
journal_title:Investigative radiology
pub_type: 杂志文章
doi:10.1097/00004424-199904000-00005
更新日期:1999-04-01 00:00:00