Estrogens antagonize apomorphine-induced yawning in rats.

abstract：:Cumulative dose-response curves of Ca2+-induced tension increments were studied in K+-depolarized helical strips of dog coronary arteries. Adenosine 10(-4) M reduced the Ca2+ sensitivity of the strips without altering the maximal tension with full Ca2+ activation. In contrast, acidosis of pH 7.05 significantly diminis...

journal_title：European journal of pharmacology

authors： Turnheim K,Pittner H,Kolassa N,Kraupp O

更新日期：1977-01-21 00:00:00

abstract：:Dorsal root potentials were recorded from urethane-anaesthetised rats. Bicuculline, a recognised GABA antagonist, reduced the amplitude of the potential to 67% of control. Cismethrin, a synthetic pyrethroid insecticide, enhanced the potential to 142% of control values. The convulsions associated with cismethrin poison...

journal_title：European journal of pharmacology

authors： Smith PR

更新日期：1980-08-22 00:00:00

abstract：:The effects of four fluoroquinolones (sparfloxacin, fleroxacin, ofloxacin and levofloxacin) on K(+) currents were investigated in pyramidal neurons acutely isolated from rat hippocampus, to evaluate their relative potencies for inhibiting these channels. Using patch-clamp electrophysiological techniques, we found that...

journal_title：European journal of pharmacology

authors： Zhang LR,Li MH,Cheng NN,Chen BY,Wang YM

更新日期：2003-02-21 00:00:00

abstract：:We have investigated the cardiac and pressor responses to (±)-ephedrine and (-)-ephedrine in pentobarbitone anaesthetized male wistar rats. The tachycardiac responses to (±)- and (-)-ephedrine were similar, but pressor responses to (-)-ephedrine (10 mg/kg) were significantly greater than those to (±)-ephedrine, and fo...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2018-04-15 00:00:00

abstract：:Effluents from perfused acetylcholine-relaxed endothelium segments of rabbit aorta (or canin femoral artery) contained endothelium-derived relaxing factors (EDRF) which dilated the endothelium-free segments of rabbit femoral artery (or side branches of canine femoral artery). The half-life of EDRF was 24 +/- 3 s for t...

journal_title：European journal of pharmacology

authors： Förstermann U,Trogisch G,Busse R

更新日期：1984-11-27 00:00:00

abstract：:Potentiation by neuropeptide Y of serotonin (5-HT)-induced vasoconstriction was investigated in porcine coronary artery. 5-HT caused concentration-dependent contraction through 5-HT2A receptors. Neuropeptide Y (30 nM) significantly increased the 5HT-induced contraction by 16+/-5% in arteries with intact endothelium. R...

journal_title：European journal of pharmacology

authors： Tsurumaki T,Nagai S,Bo X,Toyosato A,Higuchi H

更新日期：2006-08-21 00:00:00

abstract：:Obese mice display overactive bladder (OAB) associated with impaired urethra smooth muscle (USM) function. In this study, we evaluated the role of the adipose tissue surrounding the urethra and prostate in obese mice (here referred as periprostatic adipose tissue; PPAT) to the USM dysfunction. Male C57BL6/JUnib mice f...

journal_title：European journal of pharmacology

authors： Alexandre EC,Calmasini FB,Sponton ACDS,de Oliveira MG,André DM,Silva FH,Delbin MA,Mónica FZ,Antunes E

更新日期：2018-10-05 00:00:00

abstract：:Two experiments were designed to elucidate the involvement of the hypothalamic-pituitary-adrenal axis and the 5-hydroxytryptamine (5-HT) system in the acquisition of lithium chloride-conditioned taste aversion. In Experiment 1, rats were administered either vehicle or 50 mg/kg nefazodone daily for 4 weeks. Rats were t...

journal_title：European journal of pharmacology

authors： Gorzalka B,Hanson L,Harrington J,Killam S,Campbell-Meiklejohn D

更新日期：2003-06-20 00:00:00

abstract：:Phenoxybenzamine greatly attenuated phenylephrine-induced contractions of dog saphenous vein in vitro, but had less effect on contractions induced by clonidine. The phenoxybenzamine-resistant responses to clonidine were not affected by prazosin or by corynanthine but were competitively antagonized by yohimbine (pA2 8....

journal_title：European journal of pharmacology

authors： Constantine JW,Lebel W,Archer R

更新日期：1982-12-03 00:00:00

abstract：:Cutaneous arteries are known to constrict in response to cooling via α2C-adrenoceptors. The involvement of α1-adrenoceptors in the cooling response has also recently been suggested by in vivo studies in mice. The present study was thus aimed to confirm it in the isolated mouse cutaneous plantar artery. Changes in vess...

journal_title：European journal of pharmacology

authors： Goto K,Saito SY,Ishikawa T

更新日期：2014-11-05 00:00:00

abstract：:The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED50 2.6 micrograms/rat). Microinjections of morph...

journal_title：European journal of pharmacology

authors： Kawajiri S,Satoh M

更新日期：1985-04-23 00:00:00

abstract：:Prazosin is believed to have an antihypertensive action due to a selective blockade of alpha-adrenoceptors on vascular smooth muscle. Using an in vitro autoradiographic technique specific binding of [3H]prazosin to the abdominal aorta and renal artery in the rat has been shown. The binding of [3H]prazosin to arterial ...

journal_title：European journal of pharmacology

authors： Dashwood M,Bagnall J

更新日期：1982-02-19 00:00:00

abstract：:The mechanisms underlying the antinociception induced by morphine or U-50,488H (trans-(+-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]- cyclohexyl)benzeneacetamide) against painful colonic distension were examined in anaesthetized rats. The respective ED50 values for morphine and U-50,488H were 0.34 and 0.35 mg/kg for...

journal_title：European journal of pharmacology

authors： Diop L,Rivière PJ,Pascaud X,Dassaud M,Junien JL

更新日期：1994-05-12 00:00:00

abstract：:Rings of canine bronchi were suspended for isometric tension recording. Contractions produced by exogenously added acetylcholine were inhibited by pirenzepine and pancuronium. The pKB values were 6.76 for pirenzepine (calculated at 10(-6) M) and 5.30 and 5.13 for pancuronium (calculated at 10(-5) and 3 X 10(-5) M, res...

journal_title：European journal of pharmacology

authors： O'Rourke ST,Flavahan NA,Vanhoutte PM

更新日期：1987-08-04 00:00:00

abstract：:meta-Substituted 2-chlorophenyl(imino)imidazolidines of the clonidine-type (2,3- and 2,5-substituted derivatives) were used in attempts to discriminate between alpha-adrenergic effects (central hypotensive and peripheral hypertensive activities) in rats. The central hypotensive activity of four pairs of substitution i...

journal_title：European journal of pharmacology

authors： de Jonge A,Slothorst-Grisdijk FP,Timmermans PB,Van Zwieten PA

更新日期：1981-05-22 00:00:00

abstract：:The pharmacological effects of Neuropeptide FF (NPFF) analogs exhibiting different selectivities towards Neuropeptide FF1 (NPFF1) and Neuropeptide FF2 (NPFF2) receptors were investigated after supraspinal administration in mice. Injected into the third ventricle, VPNLPQRF-NH2, which is selective for Neuropeptide FF1 r...

journal_title：European journal of pharmacology

authors： Quelven I,Roussin A,Zajac JM

更新日期：2005-01-31 00:00:00

abstract：:Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg...

journal_title：European journal of pharmacology

authors： Tian R,Yang W,Xue Q,Gao L,Huo J,Ren D,Chen X

更新日期：2016-01-15 00:00:00

abstract：:We investigated the effects of acute p.o. pretraining treatment with an indirect acetylcholinesterase inhibitor, metrifonate, on water maze spatial navigation and passive avoidance behavior. Metrifonate (10-100 mg/kg, orally, p.o.) did not improve the water maze or passive avoidance performance of young intact rats. H...

journal_title：European journal of pharmacology

authors： Riekkinen P Jr,Schmidt B,Stefanski R,Kuitunen J,Riekkinen M

更新日期：1996-08-08 00:00:00

abstract：:Enterobacteria are known to deconjugate amino acid-conjugated bile acids in the intestine. Administration of ampicillin (ABPC; 3 days, 100mg/kg) decreased the expression of ileal farnesoid X receptor (Fxr) target genes, and increased the levels of total bile acids in the intestinal lumen. The primary tauro-conjugates ...

journal_title：European journal of pharmacology

authors： Kuribayashi H,Miyata M,Yamakawa H,Yoshinari K,Yamazoe Y

更新日期：2012-12-15 00:00:00

abstract：:Removal of the epithelium increased the responsiveness of isolated guinea-pig trachea to the contractile effects of endothelin. This phenomenon was observed in the presence of indomethacin (5 microM), captopril (10 microM), bacitracin (20 micrograms/ml) or leupeptin (50 microM), but was inhibited by phosphoramidon (10...

journal_title：European journal of pharmacology

authors： Hay DW

更新日期：1989-11-21 00:00:00

abstract：:The influence of GABA-ergic stimulation on the centrally evoked pressor and tachycardic responses to substance P (SP) was investigated in conscious rats. Intracerebroventricular (i.c.v.) pretreatment with the potent GABA agonist muscimol attenuated the pressor responses to i.c.v. administered SP in a dose-dependent an...

journal_title：European journal of pharmacology

authors： Schneider B,Ganten D,Lang RE,Unger T

更新日期：1986-11-12 00:00:00

abstract：:The melanocortin subtype 4 (MC4) receptor has been postulated to be involved in stress and stress-related behavior. We made use of melanocortin MC4 receptor agonists and antagonist to investigate the relationship between the melanocortin MC4 receptor and stress related disorders. The nonspecific melanocortin receptor ...

journal_title：European journal of pharmacology

authors： Chaki S,Ogawa S,Toda Y,Funakoshi T,Okuyama S

更新日期：2003-08-01 00:00:00

abstract：:The effects of 26 anesthetic agents were studied on the rhythmical discharge activity of a single isolated neuron (crayfish stretch receptor). Many of these agents produced concentration-dependent biphasic responses (excitation and depression), and some also induced altered discharge patterns (burst activity). The dom...

journal_title：European journal of pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-07-02 00:00:00

abstract：:Arteries were isolated from male DBA/2 mice and mounted on a small vessel wire myograph for isometric recording. Responses to exogenous noradrenaline were inhibited with high affinity by prazosin (pKB, 9.3) and 5-methyl-urapidil (pKB, 9.2) and with low affinity by 8-[2-[4-(2-methoxyphenyl)-1 piperazinyl]ethyl]-8-azasp...

journal_title：European journal of pharmacology

authors： Zacharia J,Hillier C,Macdonald A

更新日期：2004-10-25 00:00:00

abstract：:Capsaicin (1-3 microM) and electrical stimulation of mesenteric nerves in the presence of hexamethonium and guanethidine antidromically stimulate extrinsic sensory nerve fibers to produce a specific slow depolarizing response of myenteric neurons and a contractile response of muscles in the isolated guinea-pig ileum, ...

journal_title：European journal of pharmacology

authors： Takaki M,Namba T,Fujii W,Suga H

更新日期：1993-06-11 00:00:00

abstract：:The impacts of prenatal propofol on cognition and emotion of offspring remain elusive. In the present study, pregnant rats in the second trimester were anesthetized with propofol. Neuronal apoptosis and proliferation was determined in fetuses and postnatal rats by detecting caspase-3 and BrdU expression. The offspring...

journal_title：European journal of pharmacology

authors： Chen D,Qi X,Zhuang R,Cao J,Xu Y,Huang X,Li Y

更新日期：2019-01-15 00:00:00

abstract：:Some studies have suggested that drug tolerance observed following repeated benzodiazepine exposure may be associated with the development of a subsensitivity to gamma-aminobutyric acid (GABA) in dorsal raphe and hippocampal neurons. In other areas such as the substantia nigra such subsensitivity has not been found. T...

journal_title：European journal of pharmacology

authors： Hutchinson MA,Smith PF,Darlington CL

更新日期：1996-04-22 00:00:00

abstract：:3-(Benzo[b]furan-5-yl)-2', 6'-dihydroxy-4'-methylpropiophenone-2'-O-(6-O-methoxycarbonyl)-bet a-D -glucopyranoside (T-1095) is a derivative of phlorizin, a potent inhibitor of Na(+)-glucose cotransporters. We determined the antidiabetic effect of T-1095 in neonatally streptozotocin-treated diabetic rats. Orally admini...

journal_title：European journal of pharmacology

authors： Oku A,Ueta K,Nawano M,Arakawa K,Kano-Ishihara T,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T

更新日期：2000-03-10 00:00:00

abstract：:Increased phasic activity in the bladder smooth muscle of animal models and patients with detrusor overactivity has been suggested to underlie the pathophysiology of overactive bladder. Potassium (K+) channels are key regulators of bladder smooth muscle tone and thus may play a role in this altered phasic activity. In...

journal_title：European journal of pharmacology

authors： Vahabi B,Lawson K,McKay NG,Sellers DJ

更新日期：2011-06-25 00:00:00

abstract：:In rats adapted to a +30 degrees C temperature for one week, transfer to a temperature of +4 degrees C increased immunoassay-able serum TSH from 150-300 ng/ml to 800-2000 ng/ml in 30 min. Since this response, as well as the level of serum TSH without stimulation, were decreased by reserpine, phentolamine, phenoxybenza...

journal_title：European journal of pharmacology

authors： Tuomisto J,Ranta T,Männistö P,Saarinen A,Leppälioto J

更新日期：1975-02-01 00:00:00