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Role of vagal afferents in the antinociception produced by morphine and U-50,488H in the colonic pain reflex in rats.

Abstract：

:The mechanisms underlying the antinociception induced by morphine or U-50,488H (trans-(+-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]- cyclohexyl)benzeneacetamide) against painful colonic distension were examined in anaesthetized rats. The respective ED50 values for morphine and U-50,488H were 0.34 and 0.35 mg/kg for the i.v. route, and 1.68 and 167 micrograms/rat for the i.c.v. route. Morphine was active by the intrathecal route (ED50 = 7.8 micrograms) whereas U-50,488H had no effect at doses up to 100 micrograms/rat. The morphine response was selectively antagonized by naloxone (30 micrograms/kg i.v.) whereas that of U-50,488H was blocked by nor-binaltorphimine (10 mg/kg s.c.). Bilateral vagotomy abolished the response to morphine at 0.35 mg/kg i.v. and reduced by 41.3% that to 1 mg/kg morphine, but had no effect on that to U-50,488H or i.c.v. morphine (10 micrograms/rat). It is concluded that peripheral mu- and kappa-opioid receptors may produce antinociception for colonic pain and that vagal integrity is required for mu-opioid but not kappa-opioid peripheral antinociception.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Diop L,Rivière PJ,Pascaud X,Dassaud M,Junien JL

doi

10.1016/0014-2999(94)90710-2

subject

Has Abstract

pub_date

1994-05-12 00:00:00

pages

181-7

issue

1-2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(94)90710-2

journal_volume

257

pub_type

杂志文章

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