当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > The tail-flick inhibition induced by beta-endorphin administered intrathecally is mediated by activation of kappa- and mu-opioid receptors in the mouse.

The tail-flick inhibition induced by beta-endorphin administered intrathecally is mediated by activation of kappa- and mu-opioid receptors in the mouse.

Abstract：

:The inhibition of the tail-flick response induced by beta-endorphin given i.c.v. has been demonstrated to be mediated by the stimulation of epsilon- but not mu-, delta- or kappa-opioid receptors. beta-Endorphin given i.t. also inhibited the tail-flick response. The present studies were designed to determine what types of opioid receptors in the spinal cord were involved in i.t. beta-endorphin-induced tail-flick inhibition. Blockade of kappa-opioid receptors by coadministration of nor-binaltorphimine or Win 44,441-3 with beta-endorphin given i.t. dose dependently inhibited i.t. beta-endorphin-induced inhibition of the tail-flick response. Blockade of mu-opioid receptors by i.t. coadministration of D-Phe-Cys-Tyr-D-Try-Orn-Thr-Pen-Thr-NH2 with beta-endorphin blocked i.t. beta-endorphin-induced inhibition of the tail-flick response. I.t. injection of delta-opioid receptors antagonists, ICI 174,864 and naltrindole, or epsilon-opioid receptor antagonist, beta-endorphin-(1-27), did not affect inhibition of the tail-flick response induced by beta-endorphin given i.t. Blockade of alpha 2-adrenoceptors and 5-HT receptors by i.t. injection of yohimbine and methysergide, respectively, also did not affect inhibition of the tail-flick response induced by beta-endorphin given i.t. The results indicate that the inhibition of the tail-flick response induced by beta-endorphin given i.t. is mediated by the stimulation of kappa- and mu-opioid receptors but not delta- and epsilon-opioid receptors, alpha 2-adrenoceptors or 5-HT receptors.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Tseng LF,Collins KA

doi

10.1016/0014-2999(92)90096-m

keywords:

subject

Has Abstract

pub_date

1992-04-07 00:00:00

pages

59-65

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(92)90096-M

journal_volume

214

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium.

    abstract：:Isolated rat mast cells were used to study whether ionophore A23187 could induce histamine release by mobilizing cellular calcium. The histamine release was a slow process which was completed after about 20 min incubation with A23187. The A23187-induced histamine release was inhibited after incubation of the cells wit...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(80)90100-4

    authors： Johansen T

    更新日期：1980-04-04 00:00:00

  • Effects of prolactin on tyrosine hydroxylase activity of central dopaminergic neurons of male rats.

    abstract：:Previous work from our laboratory has indicated that ovine prolactin can produce a rapid stimulation (within 1 h) of dopamine release from nigrostriatal and mesolimbic dopaminergic neurons of male rats. In the present experiment we attempted to determine whether this effect of prolactin was a function of an increase i...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90361-0

    authors： Chen JC,Ramirez VD

    更新日期：1989-08-03 00:00:00

  • Infusion of D-cycloserine into temporal-hippocampal areas and restoration of mnemonic function in rats with disrupted glutamatergic temporal systems.

    abstract：:Partial transections of the fiber connections between the temporal cortex and the lateral entorhinal cortex at a site of the white matter corresponding to the perirhinal cortex result in impaired visual memory accompanied by reduced concentrations of glutamate in both the temporal cortex and lateral entorhinal cortex....

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)83019-1

    authors： Myhrer T,Paulsen RE

    更新日期：1997-06-05 00:00:00

  • Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neurons.

    abstract：:Acid-sensing ion channels (ASICs), a family of proton-gated cation channels, are believed to mediate pain caused by extracellular acidification. Gastrodin is a main bioactive constituent of the traditional herbal Gastrodia elata Blume, which has been widely used in Oriental countries for centuries. As an analgesic, ga...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2014.02.044

    authors： Qiu F,Liu TT,Qu ZW,Qiu CY,Yang Z,Hu WP

    更新日期：2014-05-15 00:00:00

  • The nicotinic acetylcholine receptor of the bovine chromaffin cell, a new target for dihydropyridines.

    abstract：:The effects of 1,4-dihydropyridine derivatives on divalent cation transients and catecholamine release stimulated by either high K+ or the nicotinic receptor agonist dimethyl-phenyl-piperazinium (DMPP) have been compared in bovine adrenal chromaffin cells. The activation of Ca2+ entry pathways was followed by measurin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0922-4106(93)90078-n

    authors： López MG,Fonteríz RI,Gandía L,de la Fuente M,Villarroya M,García-Sancho J,García AG

    更新日期：1993-10-15 00:00:00

  • Effect of uncouplers of oxidative phosphorylation on transmitter release in dystrophic mice.

    abstract：:Intracellular recording was used to study the effect of uncouplers of oxidative phosphorylation on miniature endplate potentials (m.e.p.p.s) in skeletal muscles from dystrophic mice and their clinically normal littermates. Control m.e.p.p. frequency in muscles from dystrophic mice was not significantly different from ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90637-1

    authors： Kelly S,Morgan G,Smith J

    更新日期：1988-02-16 00:00:00

  • Calcium channelopathies and Alzheimer's disease: insight into therapeutic success and failures.

    abstract：:Calcium ions are versatile and universal biological signaling factors that regulate numerous cellular processes ranging from cell fertilization, to neuronal plasticity that underlies learning and memory, to cell death. For these functions to be properly executed, calcium signaling requires precise regulation, and fail...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejphar.2013.11.012

    authors： Chakroborty S,Stutzmann GE

    更新日期：2014-09-15 00:00:00

  • Furosemide-induced glucose intolerance in mice is associated with reduced insulin secretion.

    abstract：:The effect of furosemide on carbohydrate metabolism was studied in ob/ob mice. Intraperitoneal injection of a single dose of furosemide (200 mg/kg body weight) into fasted mice resulted in acute hyperglycaemia and two days after such a single dose, the mice showed fasting hyperglycaemia and glucose intolerance. Pancre...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90175-6

    authors： Sandström PE,Sehlin J

    更新日期：1988-03-15 00:00:00

  • Alpha 1-adrenoceptors: function and phosphorylation.

    abstract：:This review focuses on alpha(1)-adrenoceptor phosphorylation and function. Most of what is currently known is based on studies on the hamster alpha(1B)-adrenoceptor. It is known that agonist stimulation leads to homologous desensitization of these receptors and current evidence indicates that such decrease in receptor...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s0014-2999(99)00896-1

    authors： García-Sáinz JA,Vázquez-Prado J,del Carmen Medina L

    更新日期：2000-02-11 00:00:00

  • EP3 receptor-mediated inhibition of the neurogenic vasopressor response in pithed rats.

    abstract：:In pithed rats, we studied the effects of prostaglandin E2 and of subtype-selective prostaglandin E receptor (EP receptor) ligands on the rise in blood pressure induced by electrical stimulation of the preganglionic sympathetic nerves. Prostaglandin E2, the EP1/EP3 receptor agonist sulprostone and the EP2/EP3 receptor...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(94)90660-2

    authors： Malinowska B,Godlewski G,Buczko W,Schlicker E

    更新日期：1994-07-11 00:00:00

  • Ugonin K-stimulated osteogenesis involves estrogen receptor-dependent activation of non-classical Src signaling pathway and classical pathway.

    abstract：:We have reported previously that ugonin K, a flavonoid isolated from Helminthostachys zeylanica (L.) Hook, potently induces cell differentiation and mineralization of MC3T3-E1 mouse osteoblast-like cells. Here we aimed to elucidate whether ugonin K evoked osteogenesis required interaction with estrogen receptor. Resul...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2011.12.001

    authors： Lee CH,Huang YL,Liao JF,Chiou WF

    更新日期：2012-02-15 00:00:00

  • Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice.

    abstract：:Tricyclic antidepressants have analgesic and sedative effects in addition to their antidepressive properties. We tested the acute analgesic and locomotor inhibitory effects of the tricyclic antidepressant amitriptyline and the alpha(2)-adrenoceptor agonist clonidine in wild-type control and in alpha(2A)-adrenoceptor k...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.11.047

    authors： Ozdoğan UK,Lähdesmäki J,Mansikka H,Scheinin M

    更新日期：2004-02-06 00:00:00

  • Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats.

    abstract：:The efficacy of a combinational prophylactic regimen on the lethality, convulsions, and loss of morphological and functional integrities of the brain induced by an organophosphate soman was investigated in rats. The rats were implanted subcutaneously with osmotic minipumps containing the combinational prophylactic reg...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.10.034

    authors： Choi EK,Park D,Yon JM,Hur GH,Ha YC,Che JH,Kim J,Shin S,Jang JY,Hwang SY,Seong YH,Kim DJ,Kim JC,Kim YB

    更新日期：2004-11-28 00:00:00

  • Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide.

    abstract：:Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived N...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.09.037

    authors： Atef Y,El-Fayoumi HM,Abdel-Mottaleb Y,Mahmoud MF

    更新日期：2017-11-15 00:00:00

  • Activation of epithelial sodium channel in human middle ear epithelial cells by dexamethasone.

    abstract：:The middle ear epithelium functions to maintain a fluid-free middle ear cavity. Dysfunction of the middle ear epithelial ion and fluid transport is implicated in the pathogenesis of fluid collection in the middle ear cavity, characteristic of otitis media with effusion. The efficacy of steroid therapy for the treatmen...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.11.012

    authors： Son EJ,Kim SH,Park HY,Kim SJ,Yoon JH,Chung HP,Choi JY

    更新日期：2009-01-14 00:00:00

  • Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.

    abstract：:The Na(+)/Ca(2+) exchanger (NCX) is involved in myocardial ischemia-reperfusion injuries. We examined the effects of 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a potent and selective inhibitor of NCX, on myocardial ischemia-reperfusion injury models. In canine cardiac sarcolemmal vesicles an...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(02)02732-2

    authors： Takahashi K,Takahashi T,Suzuki T,Onishi M,Tanaka Y,Hamano-Takahashi A,Ota T,Kameo K,Matsuda T,Baba A

    更新日期：2003-01-01 00:00:00

  • Characterisation of muscarinic receptor subtypes in avian smooth muscle.

    abstract：:The identity of the muscarinic receptor subtype in the chick ileum was investigated in functional and binding studies. Preliminary studies [Choo, L.-K., Mitchelson, F., Napier, P. 1988. J. Auton. Pharmacol. 8, 259-266] suggested apparent avian and mammalian family differences in the muscarinic receptor profile of ilea...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(00)00489-1

    authors： Darroch S,Irving HR,Mitchelson FJ

    更新日期：2000-08-18 00:00:00

  • Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.

    abstract：:Therapeutic angiogenesis is a promising strategy for treating ischemia. The lysophospholipid mediator sphingosine-1-phosphate (S1P) acts on vascular endothelial cells to stimulate migration and tube formation, and plays the critical role in developmental angiogenesis. We developed poly(lactic-co-glycolic-acid) (PLGA)-...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2010.02.038

    authors： Qi X,Okamoto Y,Murakawa T,Wang F,Oyama O,Ohkawa R,Yoshioka K,Du W,Sugimoto N,Yatomi Y,Takuwa N,Takuwa Y

    更新日期：2010-05-25 00:00:00

  • Spinal kappa-opioid receptor-mediated antinociception is stimulus-specific.

    abstract：:The intrathecal injection of a variety of selective kappa-opioid receptor ligands did not result in significant inhibition of thermal nociceptive tail flick responses in rats. In contrast, these compounds dose dependently inhibited pressure nociceptive responses. Cross-tolerance studies revealed that the kappa-opioid ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90223-8

    authors： Schmauss C

    更新日期：1987-06-04 00:00:00

  • Cationic derivative of dextran reverses anticoagulant activity of unfractionated heparin in animal models of arterial and venous thrombosis.

    abstract：:Heparin is a natural polymer widely used in medicine especially during the treatment of cardiovascular diseases since it is a potent blood anticoagulant. In case of emergency, e.g., massive hemorrhage, the anticoagulant activity of heparin has to be quickly stopped by the administration of a heparin reversing agent. C...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.04.037

    authors： Kalaska B,Sokolowska E,Kaminski K,Szczubialka K,Kramkowski K,Mogielnicki A,Nowakowska M,Buczko W

    更新日期：2012-07-05 00:00:00

  • Effect of cyclosporin A on morphine-induced place conditioning in mice: involvement of nitric oxide.

    abstract：:Cyclosporin A is shown to attenuate antinociceptive effects of morphine, development and expression of morphine-induced tolerance and dependency via nitric oxide (NO) pathway. In the present study, the effect of systemic cyclosporin A on morphine-induced conditioned place preference (CPP) and the probable involvement ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.11.025

    authors： Motiei Langroudi R,Khoshnoodi MA,Abadi NY,Tahsili Fahadan P,Ghahremani MH,Dehpour AR

    更新日期：2005-01-10 00:00:00

  • Effects of KC 2450 on the lower esophageal sphincter in vivo and in vitro.

    abstract：:The effect of KC 2450 (racemic 3,5-cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride) on lower esophageal sphincter pressure in pentobarbital-anesthetized dogs was determined and compared to the effect of metoclopramide. The ED20 value (i.e. the dose that increased lower esophageal sphincter pressu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90111-7

    authors： Fowler PJ,Nelson AH,Price WJ,Sarau HM,Grous M,Lombardi DM,Barone FC,Ormsbee HS 3rd

    更新日期：1987-10-13 00:00:00

  • Autoradiographic analysis of receptors on vascular endothelium.

    abstract：:Receptor autoradiography was used to examine the distribution of muscarinic cholinoceptors ([3H]QNB), alpha 2-adrenoceptors ([3H]rauwolscine), beta-adrenoceptors ([125I]CYP) and substance P receptors ([125I]BHSP) in rabbit aorta, pulmonary artery, rat aorta, dog aorta, splenic, renal and coronary arteries, bovine aort...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90128-2

    authors： Stephenson JA,Summers RJ

    更新日期：1987-01-28 00:00:00

  • Further evidence that extrinsic acetylcholine acts preferentially on extrajunctional receptors in the chick biventer cervicis muscle.

    abstract：:The specificity of action of extrinsic acetylcholine on extrajunctional and junctional receptors in the chick biventer cervicis muscle was studied by determining its ability to protect the responses evoked by acetylcholine and by tetanic nerve stimulation from the blockade by alpha-bungarotoxin, an irreversible bindin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(75)90178-8

    authors： Chang CC,Su MJ

    更新日期：1975-09-01 00:00:00

  • Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice.

    abstract：:Itching is known as a commonly side effect of opioid administration. However, the relationship of opioid receptors to itching is unclear. In this study, we examined the effect of intradermal injection of morphine and fentanyl on the itching sensation. When injected intradermally into the rostral back of mice, morphine...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2009.10.066

    authors： Yamamoto A,Kuyama S,Kamei C,Sugimoto Y

    更新日期：2010-02-10 00:00:00

  • Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region.

    abstract：:We investigated the effects of repeated electroconvulsive shock or imipramine treatment on inositol phosphate accumulation and on the reactivity of neurons to metabotropic glutamate (mGlu) receptor agonists in rat hippocampal slices. (1S,3R)-1-carboxycyclopentane-3-acetic acid (1S,3R-ACPD), a nonselective mGlu recepto...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00169-1

    authors： Pilc A,Brański P,Pałucha A,Tokarski K,Bijak M

    更新日期：1998-05-15 00:00:00

  • Drop in endo/sarcoplasmic calcium precedes the unfolded protein response in Brefeldin A-treated vascular smooth muscle cells.

    abstract：:The present study addresses the causal relationship between induction of endo/sarcoplasmic reticulum stress and dysregulation of calcium transport, while examining whether the most widely-used experimental endo/sarcoplasmic reticulum stressors can be considered appropriate for elucidating underlying cellular mechanism...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2015.07.026

    authors： Ziomek G,van Breemen C,Esfandiarei M

    更新日期：2015-10-05 00:00:00

  • Ca2+ release-activated channels in rat stomach smooth muscle cells.

    abstract：:In rat stomach fundus, contractions induced by Ca2+ (1.8 mM) were strikingly potentiated by thapsigargin. This potentiation was partially inhibited by the blockers of Ca2+ release activated channels (CRACs), miconazole and SK&F96365 ([1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCL]) and sli...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01537-9

    authors： Smaili SS,Cavalcanti PM,Oshiro ME,Ferreira AT,Jurkiewicz A

    更新日期：1998-01-19 00:00:00

  • The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.

    abstract：:Mitiglinide (KAD-1229), a new anti-diabetic drug, is thought to stimulate insulin secretion by closing the ATP-sensitive K+ (K(ATP)) channels in pancreatic beta-cells. However, its selectivity for the various K(ATP) channels is not known. In this study, we examined the effects of mitiglinide on various cloned K(ATP) c...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(01)01412-1

    authors： Sunaga Y,Gonoi T,Shibasaki T,Ichikawa K,Kusama H,Yano H,Seino S

    更新日期：2001-11-09 00:00:00

  • BHT-920 and LY-171555 (quinpirole) have similar affinities for striatal D-2 dopamine receptors, and similar affinities for striatal D-1 dopamine receptors.

    abstract：:The affinity of LY-171555 (quinpirole) and BHT-920 for both states of rat striatal dopamine D-1 and D-2 receptors was determined. Although these drugs have different pharmacological effects in experimental animals, we found that they had similar affinities for both D-1 and D-2 receptors. ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(89)90072-1

    authors： Ferré S,Guix T,Sallés J,Cuffí L,Badia A,Casas M

    更新日期：1989-07-18 00:00:00