Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium.

abstract：:Inhibition of glutamate carboxypeptidase (GCP) II (EC 3.4.17.21), also termed N-acetylated alpha-linked acidic dipeptidase (NAALADase), has been shown to protect against ischemic injury presumably via decreasing glutamate and increasing N-acetyl-aspartyl-glutamate (NAAG). NAAG is a potent and selective mGlu3 receptor ...

journal_title：European journal of pharmacology

authors： Thomas AG,Liu W,Olkowski JL,Tang Z,Lin Q,Lu XC,Slusher BS

更新日期：2001-10-26 00:00:00

abstract：:Environments previously associated with drug use can become one of the most common factors triggering relapse to drug-seeking behavior. To better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously p...

journal_title：European journal of pharmacology

authors： Gerasimov MR,Schiffer WK,Gardner EL,Marsteller DA,Lennon IC,Taylor SJ,Brodie JD,Ashby CR Jr,Dewey SL

更新日期：2001-03-02 00:00:00

abstract：:Heme oxygenase-1 (HO-1) significantly contributes to survival of cancer cells and is being considered as one of therapeutic targets for cancer treatment. Propyl gallate (PG) is a synthetic phenolic compound that possess a potent anti-oxidant and anti-inflammatory activities. In the present study, we investigated wheth...

journal_title：European journal of pharmacology

authors： Jo EJ,Park SJ,Kim BC

更新日期：2016-10-05 00:00:00

abstract：:Kinetin has been shown to have anti-aging effects on several different systems, including plants and human cells. Recently, we demonstrated that kinetin markedly inhibited platelet aggregation in washed human platelets. In the present study, an electron spin resonance (ESR) method was used to further evaluate the scav...

journal_title：European journal of pharmacology

authors： Hsiao G,Shen MY,Lin KH,Chou CY,Tzu NH,Lin CH,Chou DS,Chen TF,Sheu JR

更新日期：2003-04-04 00:00:00

abstract：:After spinal cord injury (SCI), there is an acute phase of alternatively activated (M2) macrophage infiltration, followed by a long-lasting phase of classically activated (M1) macrophage accumulation in the wound, which is believed to derail healing and compromize organ functions. Thus, agents which are able to modula...

journal_title：European journal of pharmacology

authors： Yang R,He J,Wang Y

更新日期：2016-11-15 00:00:00

abstract：:The effects of thyrotropin-releasing hormone (TRH), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and L-5-hydroxytryptophan (5-HTP) were studied on the monosynaptic reflex (MSR) and the polysynaptic reflex (PSR) in acute and chronic spinal rats. Radioimmunoassay showed that while chronic spinal transection (for 2 weeks)...

journal_title：European journal of pharmacology

authors： Nagano N,Ono H,Ozawa M,Fukuda H

更新日期：1988-05-10 00:00:00

abstract：:Modafinil [2-((diphenylmethyl) sulfinyl) acetamide] is a central nervous system stimulant. It has received considerable attention as a potential psychotropic agent in several psychiatric disorders. The current study was carried out to investigate the effect of modafinil after acute administration on animal models of p...

journal_title：European journal of pharmacology

authors： Gupta R,Gupta LK,Bhattacharya SK

更新日期：2014-08-05 00:00:00

abstract：:Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that has several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether SalB has neuroprotective effects in an amyloid β (Aβ) peptide-induced Alzheimer's disease mouse model. Mice were injected ...

journal_title：European journal of pharmacology

authors： Lee YW,Kim DH,Jeon SJ,Park SJ,Kim JM,Jung JM,Lee HE,Bae SG,Oh HK,Son KH,Ryu JH

更新日期：2013-03-15 00:00:00

abstract：:The acetylcholine receptor agonists, acetylcholine (10(-5)-10(-4 M), carbachol (5 x 10(-6)-5 x 10(-5) M), bethanechol (5 x 10(-5)-5 x 10(-4) M) and dimethylphenylpiperazinium (DMPP, 10(-5) M) increased the short-circuit current (Isc) in the rat colon descendens by a tetrodotoxin (TTX)-sensitive mechanism. Blockade by ...

journal_title：European journal of pharmacology

authors： Diener M,Knobloch SF,Bridges RJ,Keilmann T,Rummel W

更新日期：1989-09-13 00:00:00

abstract：:Enterobacteria are known to deconjugate amino acid-conjugated bile acids in the intestine. Administration of ampicillin (ABPC; 3 days, 100mg/kg) decreased the expression of ileal farnesoid X receptor (Fxr) target genes, and increased the levels of total bile acids in the intestinal lumen. The primary tauro-conjugates ...

journal_title：European journal of pharmacology

authors： Kuribayashi H,Miyata M,Yamakawa H,Yoshinari K,Yamazoe Y

更新日期：2012-12-15 00:00:00

abstract：:For the development of efficient pulmonary delivery systems for protein and peptide drugs, it is important to understand their transport mechanisms in alveolar epithelial cells. In this study, the uptake mechanism for FITC-insulin in cultured alveolar epithelial cell line RLE-6TN was elucidated. FITC-insulin uptake by...

journal_title：European journal of pharmacology

authors： Oda K,Yumoto R,Nagai J,Katayama H,Takano M

更新日期：2011-12-15 00:00:00

abstract：:Atherosclerosis is regarded as chronic inflammatory disease. The IL-6/STAT3 pathway plays an important role in inflammation. We previously described a small-molecule compound, Bazedoxifene, which target IL-6/STAT3 pathway and has been approved for clinical use for osteoporosis in postmenopausal women. The aim of this ...

journal_title：European journal of pharmacology

authors： Luo P,Wang Y,Zhao C,Guo J,Shi W,Ma H,Liu T,Yan D,Huo S,Wang M,Li C,Lin J,Li S,Lv J,Zhang C,Lin L

更新日期：2021-02-15 00:00:00

abstract：:The behavioral effects of methamphetamine (METH) are mediated by the striatum, which is divided into the patch compartment, which mediates limbic and reward functions, and the matrix compartment, which mediates sensorimotor tasks. METH treatment results in repetitive behavior that is related to enhanced relative activ...

journal_title：European journal of pharmacology

authors： Horner KA,Logan MC,Fisher TJ,Logue JB

更新日期：2017-02-05 00:00:00

abstract：:Previous studies have shown that treatment of guinea-pig isolated vas deferens with the affinity label periodate-oxidized ATP (2',3'-dialdehyde ATP), results in two irreversible effects on biphasic contractile responses to ATP, i.e., potentiation of the P2X purinoceptor-mediated first phase and inhibition of the ecto-...

journal_title：European journal of pharmacology

authors： Fedan JS,Grant LJ

更新日期：1995-08-04 00:00:00

abstract：:The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condi...

journal_title：European journal of pharmacology

authors： Widdop RE,Krstew E,Jarrott B

更新日期：1990-08-21 00:00:00

abstract：:The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innervated by the mesocortical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatum and nucleus accum...

journal_title：European journal of pharmacology

authors： Memo M,Missale C,Trivelli L,Spano PF

更新日期：1988-05-10 00:00:00

abstract：:Plants are a natural source of bioactive compounds such as secondary metabolites. These molecules, also called phytochemicals, are fundamental for plant survival and often show therapeutic properties used for the treatment of human diseases. Asperuloside is a secondary metabolite which belongs to iridoid glycosides an...

journal_title：European journal of pharmacology

authors： Manzione MG,Martorell M,Sharopov F,Bhat NG,Kumar NVA,Fokou PVT,Pezzani R

更新日期：2020-09-15 00:00:00

abstract：:We tested the hypothesis that relaxation of the rat mesenteric artery in response to insulin is mediated by K(+) channels. Two concentrations of insulin (10 and 100 mU/ml) induced relaxation of the artery by 6+/-1%, 24+/-3% (mean+/-S.E.M.). Denudation of the endothelium or precontraction by KCl (30 mM), clotrimazole (...

journal_title：European journal of pharmacology

authors： Iida S,Taguchi H,Watanabe N,Kushiro T,Kanmatsuse K

更新日期：2001-01-05 00:00:00

abstract：:The effects of several slow channel blockers were compared on the normal fast action potentials (APs) and the slow APs of guinea pig Purkinje fibers. In spontaneously-firing Purkinje fibers perfused with normal Tyrode solution, mesudipine (analog of nifedipine) at 10(-7) and 10(-6) M, had no significant effect on the ...

journal_title：European journal of pharmacology

authors： Molyvdas PA,Sperelakis N

更新日期：1983-03-25 00:00:00

abstract：:The actions of a purified Helicobacter pylori lipopolysaccharide (3 mg x kg(-1), i.v.) on rat gastric antral and duodenal microvascular integrity (determined as radiolabelled albumin leakage) and the expression of the inducible nitric oxide (NO) synthase (iNOS; assessed by the citrulline assay) were investigated 4 h a...

journal_title：European journal of pharmacology

authors： Kiss J,Lamarque D,Moran AP,Pozsár J,Morschl E,László F,Whittle BJ

更新日期：2001-05-25 00:00:00

abstract：:Previous reports have shown that (+/-)-YM796 (2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane) exhibits M1 agonistic activity and ameliorates cognitive impairment, and that the (-)-S isomer is active in in vitro studies. We report here the characterization of the (-)-S isomer, YM796 ((-)-(S)-2,8-dimethyl-3-methyl...

journal_title：European journal of pharmacology

authors： Wanibuchi F,Nishida T,Yamashita H,Hidaka K,Koshiya K,Tsukamoto S,Usuda S

更新日期：1994-11-24 00:00:00

abstract：:Morphine 6-glucuronide, a major metabolite of morphine with potent analgesic actions, is a potent inhibitor of intestinal motility when administered to rats by the intracerebroventricular (i.c.v.) route. Morphine 6-glucuronide was 62-fold more active than morphine in inhibiting gastrointestinal transit, whereas it was...

journal_title：European journal of pharmacology

authors： Massi P,Giagnoni G,Basilico L,Gori E,Rubino T,Parolaro D

更新日期：1994-03-03 00:00:00

abstract：:The aim of the present research was to characterize the pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel quinazolinone-based dipeptidyl peptidase-4 (DPP-4) inhibitor. Alogliptin potently inhibited human DPP-4 in vitro (mean IC(50), ~ 6.9 nM) and exhibited > 10,000-fold selectivity for DPP...

journal_title：European journal of pharmacology

authors： Lee B,Shi L,Kassel DB,Asakawa T,Takeuchi K,Christopher RJ

更新日期：2008-07-28 00:00:00

abstract：:Agomelatine is an antidepressant with a novel mechanism of action. It is a melatonergic agonist for MT1 and MT2 receptors and a serotonin (5-HT2C) receptor antagonist. Agomelatine has been suggested not to have adverse effects on sexual functions. However, the effects of chronic agomelatine administration on reproduct...

journal_title：European journal of pharmacology

authors： Canpolat S,Ulker N,Yardimci A,Bulmus O,Ozdemir G,Sahin Z,Ercan Z,Serhatlioglu I,Kacar E,Ozcan M,Turk G,Ozkan Y,Atmaca M,Yilmaz B,Kelestimur H

更新日期：2016-01-05 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic parameters of the selective serotonin reuptake inhibitor 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phtalancarbonitril (citalopram) were determined in order to find optimal conditions for augmentation of its effect on extracellular serotonin [5-hydroxytryptamine (5-HT)] through ...

journal_title：European journal of pharmacology

authors： Cremers TI,de Boer P,Liao Y,Bosker FJ,den Boer JA,Westerink BH,Wikström HV

更新日期：2000-05-26 00:00:00

abstract：:The human 5-HT transporter (hSERT) has two binding sites for 5-HT and 5-HT uptake inhibitors: the orthosteric high-affinity site and a low-affinity allosteric site. Activation of the allosteric site increases the dissociation half-life for some uptake inhibitors. The objectives of this study were 1) to identify hSERT ...

journal_title：European journal of pharmacology

authors： Plenge P,Gether U,Rasmussen SG

更新日期：2007-07-12 00:00:00

abstract：:The precursor to 5-hydroxytryptamine (5-HT), 5-hydroxytryptophan, (5-HTP, 5-50 mg.kg-1) administered subcutaneously (s.c.) to conscious, fed mice caused a dose dependent increase in faecal pellet and fluid output. To avoid provoking watery diarrhoea, all experiments were performed using 5-HTP at 10 mg.kg-1. This dose ...

journal_title：European journal of pharmacology

authors： Banner SE,Smith MI,Bywater D,Gaster LM,Sanger GJ

更新日期：1996-07-18 00:00:00

abstract：:In the present studies, we have examined the effects of two new Ca(2+) channel blockers, LY042826 (N-[2-[(2-methylphenyl)(phenyl)methoxy]ethyl]-1-butanamine hydrochloride) and LY393615 (N-[[5, 5-bis(4-fluorophenyl)tetrahydro-2-furanyl]methyl]-1-butanamine hydrochloride) in the gerbil model of global and the endothelin...

journal_title：European journal of pharmacology

authors： Hicks CA,Ward MA,O'Neill MJ

更新日期：2000-11-24 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been suggested to play an important role in the development of drug dependence and withdrawal. Based on the recent finding that CRF receptor antagonists inhibit the stress-induced relapse to opiate dependence and attenuate anxiety-like responses related to cocaine withdrawal, t...

journal_title：European journal of pharmacology

authors： Lu L,Liu D,Ceng X

更新日期：2001-03-01 00:00:00

abstract：:We have investigated, by using the whole-cell patch-clamp technique, the Ca2+ channel antagonist properties of eliprodil in cultured cerebellar granule cells which are known to express L-, N-, P- as well as Q- and R-type Ca2+ channels. Eliprodil maximally antagonized 50% of the voltage-dependent Ba2+ current with an I...

journal_title：European journal of pharmacology

authors： Biton B,Godet D,Granger P,Avenet P

更新日期：1997-04-04 00:00:00