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GABAergic blockade of cocaine-associated cue-induced increases in nucleus accumbens dopamine.

Abstract：

:Environments previously associated with drug use can become one of the most common factors triggering relapse to drug-seeking behavior. To better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously paired with cocaine administration. In animals exposed to a cocaine-paired environment nucleus accumbens dopamine increased by 25%. When administered 2.5 h prior to presentation of the environmental trigger, racemic vigabatrin (an irreversible inhibitor of gamma-aminobutyric acid (GABA)-transaminase) abolished this cue-induced increase. Conversely, R-(-)-vigabatrin, the inactive enantiomer, had no effect. Combined with our earlier findings, these studies support the potential therapeutic benefit of this enzyme-based GABAergic strategy to modulate brain dopamine and the subsequent treatment of drug addiction.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Gerasimov MR,Schiffer WK,Gardner EL,Marsteller DA,Lennon IC,Taylor SJ,Brodie JD,Ashby CR Jr,Dewey SL

doi

10.1016/s0014-2999(01)00800-7

keywords:

subject

Has Abstract

pub_date

2001-03-02 00:00:00

pages

205-9

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014299901008007

journal_volume

414

pub_type

杂志文章

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