当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Antiproliferative and receptor binding properties of alpha- and beta-casomorphins in the T47D human breast cancer cell line.

Antiproliferative and receptor binding properties of alpha- and beta-casomorphins in the T47D human breast cancer cell line.

Abstract：

:In previous studies, we have shown that opioid agonists ([D-Ala2, D-Leu5]enkephalin (DADLE), [D-Ser2, Leu5]enkephalin-Thr6 (DSLET), ethylketocyclazocine and etorphine) bind to opioid binding sites and decrease cell proliferation of human T47D breast cancer cells. Furthermore, we provided evidence about a cross-reaction, also in the T47D human breast cancer cell line, of mu-acting opioids with type-II somatostatin receptors. Since a potential source of opioid activity in the breast might be casomorphin peptides (produced by the enzymatic degradation of alpha-casein and beta-casein), we investigated the antiproliferative action of five different casomorphin peptides: alpha-casein-(90-95), alpha-casein-(90-96), beta-casomorphin, beta-casomorphin-(1-5) and morphiceptin. We show that all five peptides decreased, in a dose-dependent manner, cell proliferation. The general antagonist diprenorphine produced only a partial reversal of their action. Furthermore, we provide evidence that all peptides (except for morphiceptin) bind to delta- and kappa-opioid binding sites of T47D cells with different selectivity. Finally, we show that these peptides are also partial competitors at the somatostatin receptors present in the same cell line.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hatzoglou A,Bakogeorgou E,Hatzoglou C,Martin PM,Castanas E

doi

10.1016/0014-2999(96)00339-1

subject

Has Abstract

pub_date

1996-08-29 00:00:00

pages

217-23

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(96)00339-1

journal_volume

310

pub_type

杂志文章

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