Abstract:
:We compared the cumulative dose-response relations of verapamil (0.1, 0.2 and 0.4 mg kg(-1)) in different R/S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and 20/80) on the electrophysiological and hemodynamic characteristics of the heart using the conscious dogs. A reduction of mean arterial pressure occurred with 20R/80S producing a 3-times greater decrease than 100R/0S, but an increase in heart rate occurred with 20R/80S producing a 9-times greater increase than 100R/0S. Increased heart rate was concurrent with decreased mean arterial pressure most prevalent with a higher ratio of S-isomer that produced a greater reduction in mean arterial pressure and increase in heart rate at lower overall verapamil doses. Atrio-ventricular conduction time increased 3-5 min after each infusion, with 20R/80S producing a 4-times greater effect than 100R/0S. These results indicate that the peripheral and cardiac electrophysiologic properties of various nonracemic verapamil mixtures are mainly attributable to the concentration of S-isomer.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Takahata O,Krolikowski JG,McCallum JB,Lathrop DA,Bosnjak ZJdoi
10.1016/s0014-2999(98)00480-4subject
Has Abstractpub_date
1998-08-21 00:00:00pages
159-66issue
2-3eissn
0014-2999issn
1879-0712pii
S0014-2999(98)00480-4journal_volume
355pub_type
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