abstract：:Inhaled corticosteroids (ICS) are recommended treatments for all degrees of asthma severity and in combination with bronchodilators are indicated for COPD patients with a history of frequent exacerbations. However, the long-term side effects of glucocorticoids (GCs) may include increased risk of respiratory infections...

journal_title：European journal of pharmacology

authors： Marcellini A,Swieboda D,Guedán A,Farrow SN,Casolari P,Contoli M,Johnston SL,Papi A,Solari R

更新日期：2021-02-15 00:00:00

abstract：:Atherosclerosis is regarded as chronic inflammatory disease. The IL-6/STAT3 pathway plays an important role in inflammation. We previously described a small-molecule compound, Bazedoxifene, which target IL-6/STAT3 pathway and has been approved for clinical use for osteoporosis in postmenopausal women. The aim of this ...

journal_title：European journal of pharmacology

authors： Luo P,Wang Y,Zhao C,Guo J,Shi W,Ma H,Liu T,Yan D,Huo S,Wang M,Li C,Lin J,Li S,Lv J,Zhang C,Lin L

更新日期：2021-02-15 00:00:00

abstract：:Levodopa is the standard-of-care for Parkinson's disease, but continued loss of dopamine neurons with disease progression decreases its bioconversion to dopamine, leading to increased side effects and decreased efficacy. In theory, dopamine agonists could equal levodopa, but no approved oral "dopamine agonist" matches...

journal_title：European journal of pharmacology

authors： Mailman RB,Yang Y,Huang X

更新日期：2021-02-05 00:00:00

abstract：:Metastasis in breast cancer is a leading cause of mortality among women in many countries. This study investigated the anti-cancer role of benzoimidazoquinazoline and benzimidazotriazin; two novel compounds that were designed, synthesized, structurally elucidated, and biologically evaluated as potent anti-angiogenic a...

journal_title：European journal of pharmacology

authors： Hazem RM,Mohamed AA,Ghareb N,Mehanna ET,Mesbah NM,Abo-Elmatty DM,Elgawish MS

更新日期：2021-02-05 00:00:00

abstract：:Portulaca oleracea L. is used as a folk medicine in many countries because of its wide range of pharmacological effects. HM-chromanone, isolated from P. oleracea using bioassay-guided fractionation and HPLC, belongs to the homoisoflavonoid group and has been shown to exert several biological effects. In this study, we...

journal_title：European journal of pharmacology

authors： Je JY,Park JE,Seo Y,Han JS

更新日期：2021-02-05 00:00:00

abstract：:Benzodiazepines (BDZs) and non-BDZ sedative-hypnotics are effective for the management of chronic insomnia; however, they are associated with adverse effects such as headache, dizziness, and palpitations. Furthermore, long-term use of these medications is associated with decreased blood pressure (BP) or depressed baro...

journal_title：European journal of pharmacology

authors： Kagota S,Morikawa K,Ishida H,Chimoto J,Maruyama-Fumoto K,Yamada S,Shinozuka K

更新日期：2021-02-05 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor dysfunctions resulting from the loss of upper (UMNs) and lower (LMNs) motor neurons. While ALS symptoms are coincidental with pathological changes in LMNs and UMNs, the causal relationship between the two is unclear....

journal_title：European journal of pharmacology

authors： Nakagawa Y,Yamada S

更新日期：2021-02-05 00:00:00

abstract：:Rhein is one of the anthraquinones components of Rheum. It shows excellent clinical efficacy and is widely used in the management of several disease conditions including tumors, inflammation, diabetic nephropathy, and viral infections. In this review, we summarize the recent studies on the pharmacological activities o...

journal_title：European journal of pharmacology

authors： Cheng L,Chen Q,Pi R,Chen J

更新日期：2021-01-27 00:00:00

abstract：:Ulcerative colitis (UC), as an autoimmune disease, has been troubling human health for many years. Up to now, the available treatments remain unsatisfactory. Rhizoma Coptidis has been widely applied to treat gastrointestinal diseases in China for a long time, and coptisine (COP) is identified as one of its major activ...

journal_title：European journal of pharmacology

authors： Wang Y,Liu J,Huang Z,Li Y,Liang Y,Luo C,Ni C,Xie J,Su Z,Chen J,Li C

更新日期：2021-01-25 00:00:00

abstract：:Substance-related and addictive disorders (SRADs) are characterized by compulsive drug use and recurrent relapse. The persistence of pathological drug-related memories indisputably contributes to a high propensity to relapse. Hence, strategies to disrupt reconsolidation of drug reward memory are currently being pursue...

journal_title：European journal of pharmacology

authors： Rulan D,Zhenbang Y,Yipu Z,Yuan G,Galaj E,Xiaorui S,Wenshuya L,Jiaqi L,Yan Z,Chang Y,Xi Y,Li S,Yixiao L,Haishui S

更新日期：2021-01-24 00:00:00

abstract：:Fabry disease (FD) is an X-linked metabolic storage disorder arising from the deficiency of lysosomal α-galactosidase A, which leads to the gradual accumulation of glycosphingolipids, mainly globotriaosylceramide (Gb3), throughout the body. Pain in the extremities is an early symptom of FD; however, the underlying pat...

journal_title：European journal of pharmacology

authors： Sugimoto J,Satoyoshi H,Takahata K,Muraoka S

更新日期：2021-01-20 00:00:00

abstract：:Nanog is a major transcription factor related to cellular multipotency that plays important roles in the development of tumor cells, drug resistance, migration, and stemness; indicating its great potential as a therapeutic target for various malignancies including colorectal cancer (CRC). Therefore, this study was aim...

journal_title：European journal of pharmacology

authors： Khosravi N,Shahgoli VK,Amini M,Safaei S,Mokhtarzadeh A,Mansoori B,Derakhshani A,Baghbanzadeh A,Baradaran B

更新日期：2021-01-16 00:00:00

abstract：:Cancer stem cell therapy is becoming a focal point for oral squamous cell carcinoma (OSCC). They can be regulated by tumor glucose metabolism, whereas the regulation is not fully investigated in OSCC. Herein, we studied the synergistic anti-tumor effect of a LIN28 inhibitor C1632 and hypoglycemic medication metformin ...

journal_title：European journal of pharmacology

authors： Chen H,Sa G,Li L,He S,Wu T

更新日期：2021-01-15 00:00:00

abstract：:Little information is available on the influence of sex in combination with smoking habits and combined oral contraceptives (COC) use on cellular inflammatory indexes such as neutrophil/lymphocyte ratio (NLR), derived NRL (dNLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), mean platelet volume/pl...

journal_title：European journal of pharmacology

authors： Campesi I,Montella A,Sotgiu G,Dore S,Carru C,Zinellu A,Palermo M,Franconi F

更新日期：2021-01-15 00:00:00

abstract：:Phosphodiesterase 2 is one of the phosphodiesterase (PDEs) family members that regulate cyclic nucleotide (namely cAMP and cGMP) concentrations. The present study determined whether PDE2 inhibition could rescue post-traumatic stress disorder (PTSD)-like symptoms. Mice were subjected to single prolonged stress (SPS) an...

journal_title：European journal of pharmacology

authors： Chen L,Liu K,Wang Y,Liu N,Yao M,Hu J,Wang G,Sun Y,Pan J

更新日期：2021-01-15 00:00:00

abstract：:Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress-sensitive Ca2+-permeable channel. The activation of TRPM2 by H2O2 causes cell death in various types of cells. 5-Fluorouracil (5-FU) is an important anticancer drug, but myelosuppression is one of the most frequent adverse effects. The involvemen...

journal_title：European journal of pharmacology

authors： Ishibashi M,Ishii M,Yamamoto S,Mori Y,Shimizu S

更新日期：2021-01-15 00:00:00

abstract：:The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes more widely prescribed. This study aimed to examine the effects of cannabidiol on a wide range of contractile agents in rat small resistance arteries, in comparison with large arteries, and to...

journal_title：European journal of pharmacology

authors： Mazeh AC,Angus JA,Wright CE

更新日期：2021-01-15 00:00:00

abstract：:Statin therapy is used ubiquitously to reduce cholesterol levels, and recent studies have revealed statin use may be associated with a reduced risk of inflammatory bowel disease (IBD). A comprehensive assessment of the literature was performed to investigate whether statin use may influence the risk of new-onset IBD. ...

journal_title：European journal of pharmacology

authors： Bhagavathula AS,Clark C,Rahmani J

更新日期：2021-01-15 00:00:00

abstract：:Inflammatory arthritis, such as rheumatoid arthritis (RA), stands out as one of the main sources of pain and impairment to the quality of life. The use of hemopressin (PVNFKFLSH; Hp), an inverse agonist of type 1 cannabinoid receptor, has proven to be effective in producing analgesia in pain models, but its effect on ...

journal_title：European journal of pharmacology

authors： Camargo LL,Denadai-Souza A,Yshii LM,Lima C,Teixeira SA,Cerqueira ARA,Gewehr MCF,Fernandes ES,Schenka AA,Muscará MN,Ferro ES,Costa SKP

更新日期：2021-01-05 00:00:00

abstract：:Liver plays an important role in bile synthesis, metabolic function, degradation of toxins, new substances synthesis in body. However, hepatopathy morbidity and mortality are increasing year by year around the world, which become a major public health problem. Traditional Chinese medicine (TCM) has a prominent role in...

journal_title：European journal of pharmacology

authors： Zhou M,Deng Y,Liu M,Liao L,Dai X,Guo C,Zhao X,He L,Peng C,Li Y

更新日期：2021-01-05 00:00:00

abstract：:The coronavirus disease-19 (COVID-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. The lack of effective drugs or vaccine provoked the research fo...

journal_title：European journal of pharmacology

authors： M P,Reddy GJ,Hema K,Dodoala S,Koganti B

更新日期：2021-01-05 00:00:00

abstract：:The infectious coronavirus disease (COVID-19) pandemic, caused by the coronavirus SARS-CoV-2, appeared in December 2019 in Wuhan, China, and has spread worldwide. As of today, more than 46 million people have been infected and over 1.2 million fatalities. With the purpose of contributing to the development of effectiv...

journal_title：European journal of pharmacology

authors： Cavasotto CN,Lamas MS,Maggini J

更新日期：2021-01-05 00:00:00

abstract：:Cathelicidins are a class of gene-encoded multifunctional factors in host defence systems. They have recently attracted a great deal of attention as promising drug candidates. Cathelicidins are well studied in vertebrates, yet no studies have been reported concerning gecko cathelicidin. Recently, we identified a novel...

journal_title：European journal of pharmacology

authors： Cai S,Lu C,Liu Z,Wang W,Lu S,Sun Z,Wang G

更新日期：2021-01-05 00:00:00

abstract：:Parkinson's disease (PD) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the development of therapies that can stop or reverse the disease progression, identification of dependable biomarkers, and better understanding of the pathoph...

journal_title：European journal of pharmacology

authors： Iyer M,Subramaniam MD,Venkatesan D,Cho SG,Ryding M,Meyer M,Vellingiri B

更新日期：2020-12-17 00:00:00

abstract：:Growing evidences suggest the presence of several similarities in the molecular mechanisms underlying the neurodegenerative diseases and metabolic abnormalities. Adults who develop Metabolic Syndrome (MS) are at a higher risk of developing Alzheimer's disease (AD). Pharmacological agents, like dipeptidyl peptidase-4 (...

journal_title：European journal of pharmacology

authors： Yossef RR,Al-Yamany MF,Saad MA,El-Sahar AE

更新日期：2020-12-15 00:00:00

abstract：:Salvianolate is a compound from traditional Chinese medicine widely used in the treatment of various cardiovascular diseases. This study explored the effects of salvianolate on myocardial infarction and used tandem mass tags (TMT) to discover differentially expressed proteins. Male Sprague Dawley rats were randomly di...

journal_title：European journal of pharmacology

authors： Chen C,Zhu P,Yu H,Huang B,Gui M,Lin X,Bai Y

更新日期：2020-12-15 00:00:00

abstract：:To explore the effect of intrathecal injection of lycopene on pain facilitation, glial activation, and the SIRT1/mTOR pathway in the dorsal horn of rats with burn injury pain (BIP). Here we found that the mechanical pain threshold increased in the lycopene group compared with that of the control group, (P < 0.05). Com...

journal_title：European journal of pharmacology

authors： Yin Q,Wang JF,Xu XH,Xie H

更新日期：2020-12-15 00:00:00

abstract：:A substantial barrier to the treatment of Opioid Use Disorder (OUD) is the elevated relapse rates in affected patients, and a significant contributor to these events of relapse is exposure to cues and contexts that are intensely associated with prior drug abuse. The neurotransmitter dopamine plays a key role in reward...

journal_title：European journal of pharmacology

authors： McKendrick G,Sharma S,Sun D,Randall PA,Graziane NM

更新日期：2020-12-15 00:00:00

abstract：:NTP42 is a novel antagonist of the thromboxane A2 receptor (TP) in development for the treatment of pulmonary arterial hypertension (PAH). Recent studies demonstrated that NTP42 and TP antagonism have a role in alleviating PAH pathophysiology. However, the efficacy of NTP42 when used in combination with existing PAH t...

journal_title：European journal of pharmacology

authors： Mulvaney EP,Reid HM,Bialesova L,Mendes-Ferreira P,Adão R,Brás-Silva C,Kinsella BT

更新日期：2020-12-15 00:00:00

abstract：:Overexpression of Cav3.2 T-type Ca2+ channels in L4 dorsal root ganglion (DRG) participates in neuropathic pain after L5 spinal nerve cutting (L5SNC) in rats. The L5SNC-induced neuropathic pain also involves high mobility group box 1 (HMGB1), a damage-associated molecular pattern protein, and its target, the receptor ...

journal_title：European journal of pharmacology

authors： Tomita S,Sekiguchi F,Kasanami Y,Naoe K,Tsubota M,Wake H,Nishibori M,Kawabata A

更新日期：2020-12-05 00:00:00

abstract：:In Alzheimer's disease (AD), a decline in function of neural progenitor cells (NPCs) results in a reduced capacity for neural regeneration. It has been shown that plasma oxidized low-density lipoprotein (ox-LDL) levels are positively correlated with severity in patients with AD. However, the direct effects of ox-LDL o...

journal_title：European journal of pharmacology

authors： Ishizuka T,Nagata W,Nomura-Takahashi S,Satoh Y

更新日期：2020-12-05 00:00:00

abstract：:Propofol is generally used for the induction and maintenance of anesthesia in clinical procedures via activation of γ -aminobutyric acid A (GABAA) receptors. When administered at the clinical dose, propofol use is associated with movement disorders, including dystonia and ataxia, suggesting that propofol administratio...

journal_title：European journal of pharmacology

authors： Zhang XY,Zhang YD,Cui BR,Jin R,Chu CP,Jin XH,Qiu DL

更新日期：2020-11-15 00:00:00

abstract：:COVID-19 pandemic presents an unprecedented challenge to identify effective drugs for treatment. Despite multiple clinical trials using different agents, there is still a lack of specific treatment for COVID-19. Having the potential role in suppressing inflammation, immune modulation, antiviral and improving respirato...

journal_title：European journal of pharmacology

authors： Monji F,Al-Mahmood Siddiquee A,Hashemian F

更新日期：2020-11-15 00:00:00

abstract：:Colorectal cancer (CRC) has become one of the major factors of tumor-related morbidity and mortality in the world because of its poor prognosis and consequences of metastatic spread. Currently, chemoprevention has been considered as a way of preventing cancer who takes advantage of plant phytochemicals and synthetic c...

journal_title：European journal of pharmacology

authors： Zhu Y,Yang Q,Liu H,Song Z,Chen W

更新日期：2020-11-15 00:00:00

abstract：:We aimed at investigating the influence of clomipramine and selegiline administered in vivo in mice on lymphocyte subsets in lymphoid organs and SRBC-induced humoral immune response. Balb/c mice were given 7 or 14 oral doses (1 mg/kg) of selegiline or clomipramine. Lymphocyte B and T subsets and splenic regulatory T c...

journal_title：European journal of pharmacology

authors： Szczypka M,Sobieszczańska A,Suszko-Pawłowska A,Lis M

更新日期：2020-11-15 00:00:00

abstract：:Mutations of p53 in cancer cells not only subvert its antiproliferative properties but can also promote various oncogenic responses through a gain-of-function activity. Pharmacological manipulation of the mutant p53 pathway by specific compounds could be an effective strategy for cancer therapy. We show here that gain...

journal_title：European journal of pharmacology

authors： Zhang G,Li L,Bi J,Wu Y,Li E

更新日期：2020-11-15 00:00:00

abstract：:Hydroxytyrosol (HT), a polyphenol widely contained as an ester in olive fruits and olive leaves, exhibits a broad spectrum of effectiveness. The present study was designed to investigate the effect of HT alone as well as in the combination with cisplatin on the House Ear Institute-Organ of Corti 1 cells (HEI-OC1) and ...

journal_title：European journal of pharmacology

authors： Zhang W,Man R,Yu X,Yang H,Yang Q,Li J

更新日期：2020-11-15 00:00:00

abstract：:The cardiac plexus, which contains parasympathetic ganglia, plays an important role in regulating cardiac function. Histamine is known to excite intracardiac ganglion neurons, but the underlying mechanism is obscure. In the present study, therefore, the effect of histamine on rat intracardiac ganglion neurons was inve...

journal_title：European journal of pharmacology

authors： Sato A,Arichi S,Kojima F,Hayashi T,Ohba T,Cheung DL,Eto K,Narushima M,Murakoshi H,Maruo Y,Kadoya Y,Nabekura J,Ishibashi H

更新日期：2020-11-05 00:00:00

abstract：:Iron-mediated oxidative stress has been recognized as one of the leading causes of chronic kidney injury. The effect of L-type calcium channel (LTCC) blocker on iron overload has been shown in cardiomyocytes, liver cells, and nerve cells. So far, few studies have examined whether blockers improve kidney iron-mediated ...

journal_title：European journal of pharmacology

authors： Sun L,Lin X,Pornprasert S,Lü X,Ran B,Lin Y

更新日期：2020-11-05 00:00:00

abstract：:Geniposide (GE) can effectively inhibit diabetic nephropathy (DN), but its mechanism is unclear. The objective of this study was to explore the antidiabetic nephropathy effects of GE both in high fat diet/streptozotocin-induced DN mice and in high glucose-induced podocyte model. Renal function in DN mice was evaluated...

journal_title：European journal of pharmacology

authors： Li F,Chen Y,Li Y,Huang M,Zhao W

更新日期：2020-11-05 00:00:00