Enkephalin mydriasis in mice.

abstract：:Statins are the most common type of medicine used to treat hypercholesterolemia; however, they are associated with a low incidence of myotoxicity such as myopathy and rhabdomyolysis. The mechanisms for the adverse effects remain to be fully elucidated for safer chronic use and drug development. The results of our earl...

journal_title：European journal of pharmacology

authors： Araki M,Maeda M,Motojima K

更新日期：2012-01-15 00:00:00

abstract：:We have examined the effect of various chemokines on neuronal toxicity in culture. In mixed cortical cultures, challenged with a brief pulse of N-methyl-D-aspartate (NMDA, 60 microM, 10 min), chemokines were either present for 2 h preceding the pulse or they were co-applied with NMDA and then kept in the medium for th...

journal_title：European journal of pharmacology

authors： Bruno V,Copani A,Besong G,Scoto G,Nicoletti F

更新日期：2000-07-07 00:00:00

abstract：:(5R)-5-hydroxytriptolide (LLDT-8) exhibits strong immunosuppressive activities in vitro and in vivo. Here, we investigated the effects of LLDT-8 on concanavalin A-induced hepatitis. Liver damage was evaluated by serum alanine transaminase (ALT) level and liver histology. The effects of LLDT-8 were determined by measur...

journal_title：European journal of pharmacology

authors： Zhou R,Tang W,Ren YX,He PL,Yang YF,Li YC,Zuo JP

更新日期：2006-05-10 00:00:00

abstract：:Adrenomedullin is a peptide recently isolated from pheochromocytoma that has vasorelaxant and long-lasting hypotensive activities. Plasma levels of adrenomedullin are elevated in patients with congestive heart failure, but the effects of adrenomedullin on the cardiac function are unclear. We, thus, investigated the ef...

journal_title：European journal of pharmacology

authors： Ihara T,Ikeda U,Tate Y,Ishibashi S,Shimada K

更新日期：2000-02-25 00:00:00

abstract：:The genes encoding the alpha3, alpha5 and beta4 subunits of nicotinic acetylcholine receptors are tightly clustered within the genome. As these three subunits constitute the predominant acetylcholine receptor subtype expressed in the peripheral nervous system, their genomic proximity suggests a regulatory mechanism en...

journal_title：European journal of pharmacology

authors： Melnikova IN,Yang Y,Gardner PD

更新日期：2000-03-30 00:00:00

abstract：:The aim of our review is to summarize common genetic variations of some receptors associated with clinical consequences, which were not outlined in the previous special issue of this journal. Because of the multiple pathomechanisms of diseases, a set of genetic variation can play a role in the development of pathologi...

journal_title：European journal of pharmacology

authors： Császár A,Abel T

更新日期：2001-02-23 00:00:00

abstract：:We show that cisplatin resistance in certain lung cancer cell lines can be reversed through inhibition of mTOR (mammalian Target of Rapamycin). These cell lines appear to possess high levels of phospho-mTOR, phospho-AKT and other growth-related proteins, such as hTERT (human telomerase reverse transcriptase), and Cycl...

journal_title：European journal of pharmacology

authors： Wangpaichitr M,Wu C,You M,Kuo MT,Feun L,Lampidis T,Savaraj N

更新日期：2008-09-04 00:00:00

abstract：:The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of alpha 1-(methoxamine) or alpha 2-...

journal_title：European journal of pharmacology

authors： Li CG,Rand MJ

更新日期：1989-09-01 00:00:00

abstract：:Many central stimulating drugs have a pronounced stimulatory effect on striatal and cortical activity which is associated to enhanced function of mesencephalic dopaminergic neurons. Mesencephalic KCNQ (also termed K(v)7) potassium channels suppress the basal activity of dopaminergic neurons in the substantia nigra and...

journal_title：European journal of pharmacology

authors： Hansen HH,Andreasen JT,Weikop P,Mirza N,Scheel-Krüger J,Mikkelsen JD

更新日期：2007-09-10 00:00:00

abstract：:The antagonist effects of ketanserin and 2'-methyl-4'-(5-methyl-1,2,4)oxadiazol-3-yl)-biphenyl-[4-carboxyli c acid 4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide (GR 127,935) were compared to naratriptan-induced inhibition of cAMP formation in C6-glial cell lines stably expressing human 5-HT1D or 5-HT1B receptor ...

journal_title：European journal of pharmacology

authors： Pauwels PJ,Colpaert FC

更新日期：1996-04-04 00:00:00

abstract：:In two separate research centres the ability of RO 15-4513 to protect rats against the lethal effects of ethanol (7.5 and 15 g/kg) was investigated. In neither study did RO 15-4513 offer protection against ethanol-induced lethality or the loss of righting reflex caused by these doses of ethanol. These data fail to rep...

journal_title：European journal of pharmacology

authors： Nutt DJ,Lister RG,Rusche D,Bonetti EP,Reese RE,Rufener R

更新日期：1988-06-22 00:00:00

abstract：:Psychostimulant abuse has been a serious social problem worldwide for a long time. Bupropion, which is used as an antidepressant and to aid smoking cessation in the US, is considered to have psychostimulant-like activity. Although activation of the dopaminergic system induces several behavioral effects and bupropion c...

journal_title：European journal of pharmacology

authors： Mori T,Shibasaki M,Ogawa Y,Hokazono M,Wang TC,Rahmadi M,Suzuki T

更新日期：2013-10-15 00:00:00

abstract：:Human adipose tissue-derived stromal cells (hADSCs) demonstrate promising potential in various clinical applications, including the transplantation to regenerate injured or degenerative tissues. The migration of engrafted hADSCs to the correct site of injure is essential for the curative effect of stem cell therapy. W...

journal_title：European journal of pharmacology

authors： Wang H,Liu TQ,Guan S,Zhu YX,Cui ZF

更新日期：2008-12-03 00:00:00

abstract：:The peptides for-Met-Leu-Tyr-OMe, for-Met-Leu-Glu-OMe, for-Met-Leu-Asp-OMe and for-Met-Leu-Ser-OMe were synthesized to investigate the importance of a hydrophilic side chain of the residue at position 3 on biological activities of human neutrophils. A number of in vitro essays were carried out, including: chemotaxis, ...

journal_title：European journal of pharmacology

authors： Spisani S,Turchetti M,Varani K,Falzarano S,Cavicchioni G

更新日期：2003-05-23 00:00:00

abstract：:It had previously been shown that D-phenylalanine and hydrocinnamic acid, two in vitro inhibitors of carboxypeptidase A, possess an analgesic action when injected i.p. in mice. We have studied the in vivo effects of indole-3-acetic acid, another carboxypeptidase A inhibitor, and of the following analogs of D-phenylala...

journal_title：European journal of pharmacology

authors： Giusti P,Carrara M,Cima L,Borin G

更新日期：1985-10-22 00:00:00

abstract：:In order to elucidate the signal transduction pathway of vascular smooth muscle contraction induced by the activation of receptors for angiotensin II and endothelin-1, we examined whether tyrosine kinases and mitogen-activated protein (MAP) kinases are involved in the development of force of contraction in the rat aor...

journal_title：European journal of pharmacology

authors： Ishihata A,Tasaki K,Katano Y

更新日期：2002-06-12 00:00:00

abstract：:Blockade of sodium channels located in the sinoatrial node can slow diastolic depolarisation rate, recorded in vitro. The objective was therefore to determine whether these blockers could slow heart rate in vivo. The heart rate was firstly measured in spontaneously beating, isolated rat heart atria in the presence of ...

journal_title：European journal of pharmacology

authors： Létienne R,Vié B,Le Grand B

更新日期：2006-01-20 00:00:00

abstract：:Somatostatin and gamma-aminobutyric acid (GABA) concentrations were evaluated in the brain of kindled rats treated chronically with carbamazepine and valproic acid. Kindled seizures were almost completely blocked by treatment with carbamazepine, whereas the effect of valproic acid was partial, suppressing only general...

journal_title：European journal of pharmacology

authors： Higuchi T,Yamazaki O,Takazawa A,Kato N,Watanabe N,Minatogawa Y,Yamazaki J,Ohshima H,Nagaki S,Igarashi Y

更新日期：1986-06-17 00:00:00

abstract：:The 5-lipoxygenase inhibitors WY-50,295 tromethamine, A-64,077, L-663,536 and ICI-207,968 were compared in a reverse passive Arthus reaction-induced pleurisy model of eicosanoid biosynthesis in the rat. When a 1 h pretreatment schedule was employed, all four inhibitors equivalently blocked leukotriene B4 (LTB4) produc...

journal_title：European journal of pharmacology

authors： Berkenkopf JW,Weichman BM

更新日期：1991-01-25 00:00:00

abstract：:The present experiments determined the effects of selective dopamine receptor antagonists on the initiation and expression of sensitization to the locomotor-stimulating effects of morphine in rats. Although both the dopamine D1 receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benza...

journal_title：European journal of pharmacology

authors： Jeziorski M,White FJ

更新日期：1995-03-14 00:00:00

abstract：:The actions of gamma-aminobutyric acid (GABA) and the receptor selective agonists, muscimol (GABAA) and baclofen (GABAB), on motor activity of the longitudinal muscle-myenteric plexus of guinea-pig distal colon were studied in vitro. Preparations exhibited spontaneous contractions that were blocked by scopolamine (1 m...

journal_title：European journal of pharmacology

authors： Minocha A,Galligan JJ

更新日期：1993-01-12 00:00:00

abstract：:The effects of a serotonin (5-HT) releasing drug, p-chloroamphetamine, on plasma glucose levels were investigated in rats. p-Chloroamphetamine elicited a significant hyperglycemia. The hyperglycemic effects of p-chloroamphetamine were completely prevented by the 5-HT synthesis inhibitor, p-chlorophenylalanine. Prior a...

journal_title：European journal of pharmacology

authors： Yamada J,Sugimoto Y,Yoshikawa T

更新日期：1998-10-23 00:00:00

abstract：:The effect of lithium ion (Li+) on receptor-mediated synthesis of cyclic GMP, a putative second messenger, was examined using intact murine neuroblastoma cells (clone N1E-115). Lithium chloride potently inhibited cyclic GMP formation stimulated by the neuropeptides, neurotensin, angiotensin II and bradykinin in an ide...

journal_title：European journal of pharmacology

authors： Kanba S,Pfenning M,Kanba KS,Richelson E

更新日期：1986-07-15 00:00:00

abstract：:5-HT and dopamine receptor antagonists have become widely used as atypical antipsychotics. Although 5-HT(2A) receptor antagonistic activity is thought to contribute to the atypical aspects of these agents, the precise mechanism remains unknown. M100907 (R(+)-alpha(2,3-dimethoxyphenyl)-1-[2(4-fluorophenyl)ethyl)]-4-pip...

journal_title：European journal of pharmacology

authors： Habara T,Hamamura T,Miki M,Ohashi K,Kuroda S

更新日期：2001-04-13 00:00:00

abstract：:A possible cross-competition between vasoactive intestinal peptide (VIP) and somatostatin (somatotropin release inhibiting factor; SRIF) and their respective receptors, was investigated at native or recombinant SRIF and VIP/pituitary adenylate cyclase-activating polypeptide (PACAP) receptors. The activity of VIP was e...

journal_title：European journal of pharmacology

authors： Hannon JP,Langenegger D,Waser B,Hoyer D,Reubi JC

更新日期：2001-08-31 00:00:00

abstract：:Barbiturates derived by minor structural changes to the butenyl sidechain of the convulsant 5-ethyl-5-(3'-methyl-but-2'-enyl)-barbituric acid are almost devoid of convulsant activity, but all have anaesthetic and anticonvulsant effects. Anticonvulsant activity is also observed in the convulsant barbiturate. Increased ...

journal_title：European journal of pharmacology

authors： Andrews PR,Jones GP,Lodge D

更新日期：1979-04-15 00:00:00

abstract：:I.v. administration of McN-2378 appeared to preferentially increase cerebral blood flow as opposed to systemic (femoral) blood flow in two strains of monkeys. This cerebral vasodilation was not affected by theta-adrenergic blockade. In the anesthetized dog, the compound transiently lowered systemic arterial pressure w...

journal_title：European journal of pharmacology

authors： Hageman WE,Pruss TP

更新日期：1975-01-01 00:00:00

abstract：:The effects of protein kinase C (PKC) activators on gamma-aminoburyric acid (GABA) rho 1 receptor function were studied in rho 1 -expressing Xenopus oocytes. The PKC activator phorbol 12-myristate 13-acetate (PMA) but not the inactive analog phorbol 12-mono-myristate inhibited the GABA-gated chloride currents. Mezerei...

journal_title：European journal of pharmacology

authors： Kusama T,Sakurai M,Kizawa Y,Uhl GR,Murakami H

更新日期：1995-11-30 00:00:00

abstract：:In rat carotid arteries isolated 2 weeks after balloon denudation, a significant neointima developed with little change in medial size. Associated with this neointimal hyperplasia was a marked decrease in contraction to various agents including angiotensins I and II, big endothelin-1, endothelin-1, norepinephrine, phe...

journal_title：European journal of pharmacology

authors： Antonaccio MJ,Normandin D,Ferrer P

更新日期：1994-04-11 00:00:00

abstract：:We previously reported that circulating lipid (malondialdehyde, MDA) and protein oxidation (carbonyl residues, CO) products can be used as markers of risk for complications in poorly controlled type 2 diabetics. Now, we aimed to evaluate the existence of a gender effect on classical disease markers and oxidative stres...

journal_title：European journal of pharmacology

authors： Lodovici M,Bigagli E,Luceri C,Mannucci E,Rotella CM,Raimondi L

更新日期：2015-11-05 00:00:00