Prejunctional inhibition of non-adrenergic non-cholinergic transmission in the rat anococcygeus muscle.

abstract：:The effects of MP 518, an acylated 2-chlorobenzylidene hydrazidone derivative with antihypertensive properties were investigated on the Ca current, ICa, recorded under whole-cell patch-clamp in single frog ventricular cells. MP 518 (1-100 microM) had no effect on ICa under control conditions. However, at 10 microM it ...

journal_title：European journal of pharmacology

authors： Scamps F,Tran G,Rinjard P,Binet P,Miocque M,Vassort G

更新日期：1993-01-15 00:00:00

abstract：:Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg...

journal_title：European journal of pharmacology

authors： Tian R,Yang W,Xue Q,Gao L,Huo J,Ren D,Chen X

更新日期：2016-01-15 00:00:00

abstract：:Electrical stimulation produced a contraction in the isolated guinea-pig vas deferens. This response was blocked by tetrodotoxin, guanethidine and bretylium but not by atropine. The magnitude of the contractile response to electrical stimulation depended on the concentration of the external calcium. Sulfur-containing ...

journal_title：European journal of pharmacology

authors： Morishita H,Sugiyama M,Furukawa T

更新日期：1983-11-11 00:00:00

abstract：:The effect of noradrenaline on 5-hydroxytryptamine (5-HT) release from isolated mouse ileal tissues was investigated. Noradrenaline, but not isoprenaline, at 1 microM stimulated 5-HT release, an effect which was inhibited by yohimbine, an alpha(2)-adrenoceptor antagonist, but not by bunazosin, an alpha(1)-adrenoceptor...

journal_title：European journal of pharmacology

authors： Hirafuji M,Ogawa T,Kato K,Hamaue N,Endo T,Parvez H,Minami M

更新日期：2001-12-07 00:00:00

abstract：:Melatonin is of considerable interest for its regulatory influence on a variety of physiological processes including biological rhythms and neuroendocrine functions. We showed that melatonin potentiates sympathetic neurotransmission in the prostatic portion of the rat vas deferens, by increasing contractions in respon...

journal_title：European journal of pharmacology

authors： Carneiro RC,Toffoleto O,Cipolla-Neto J,Markus RP

更新日期：1994-05-12 00:00:00

abstract：:The effect of eliprodil on P-type Ca2+ channels was investigated in acutely dissociated rat Purkinje neurons, by using the whole-cell patch-clamp technique. Eliprodil inhibited in a reversible manner the omega-agatoxin-IVA-sensitive Ba2+ current elicited by step depolarizations from a -80 mV holding voltage (IC50 = 1....

journal_title：European journal of pharmacology

authors： Biton B,Granger P,Depoortere H,Scatton B,Avenet P

更新日期：1995-12-27 00:00:00

abstract：:Type 1 diabetes (T1D) is a multifactorial autoimmune disease that develops as a consequence of macrophage- and T cell-dependent pancreatic β-cell death. Multiple approaches for induction of anti-inflammatory/regulatory mechanisms that would attenuate T1D have been utilized, with little or no beneficial effects. To ach...

journal_title：European journal of pharmacology

authors： Koprivica I,Gajic D,Saksida T,Cavalli E,Auci D,Despotovic S,Pejnovic N,Stosic-Grujicic S,Nicoletti F,Stojanovic I

更新日期：2019-12-01 00:00:00

abstract：:In the present study we investigated the in vivo pharmacological profile of the benz[e]indole cis-8-hydroxy-3-(n-propyl)],2,3a,4,5,9b-hexahydro-1H-benz[e]indole (cis-8-OH-PBZI), which has been described as a preferential dopamine D3 receptor agonist in vitro. The compound inhibited spontaneous locomotor activity in mi...

journal_title：European journal of pharmacology

authors： Fink-Jensen A,Nielsen EB,Hansen L,Scheideler MA

更新日期：1998-01-26 00:00:00

abstract：:This study examined the mechanism of action of neurotensin on intraluminal pressure in rat proximal colon. The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca(2+)-free solution, and was antagonized by nifedipine (1-5-10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dime...

journal_title：European journal of pharmacology

authors： Mulè F,Serio R

更新日期：1997-01-29 00:00:00

abstract：:This study examined the pharmacological characteristics of binding sites for the potent K+ channel opener [3H]P1075, as well as the functional effects of P1075 on ionic currents and membrane potential, in ovine choroid plexus (OCP) cells. [3H]P1075 bound to OCP cells with a Kd of 26 +/- 4 nM and a Bmax of 10400 +/- 48...

journal_title：European journal of pharmacology

authors： Dickinson KE,Baska RA,Cohen RB,Bryson CC,Smith MA,Schroeder K,Lodge NJ

更新日期：1998-03-12 00:00:00

abstract：:This study presents a direct comparison of the ligand binding and signaling profiles of a mammalian and non-mammalian mu opioid receptor. Opioid ligand binding and agonist potencies were determined for an amphibian (Rana pipiens) mu opioid receptor (rpMOR) and the human mu opioid receptor (hMOR) in transfected, intact...

journal_title：European journal of pharmacology

authors： Brasel CM,Sawyer GW,Stevens CW

更新日期：2008-12-03 00:00:00

abstract：:Several experiments were conducted to study the effects of established or potential antiparkinsonian drugs on the tremulous jaw movements induced by the anticholinesterase tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride). In the first group of four experiments, separate groups of animals that received 2...

journal_title：European journal of pharmacology

authors： Cousins MS,Carriero DL,Salamone JD

更新日期：1997-03-19 00:00:00

abstract：:The effects of histamine H1- and H2-receptor antagonists on histamine-stimulated renin secretion were examined in anesthetized dogs. Tripelennamine (H1 blocker) further enhanced renin secretion in the presence of exogenous histamine. Moreover, tripelennamine alone increased renin secretion. These effects are probably ...

journal_title：European journal of pharmacology

authors： Radke KJ,Willis LR,Zimmerman GW,Weinberger MH,Selkurt EE

更新日期：1986-04-29 00:00:00

abstract：:In formyl-Met-Leu-Phe (fMLP)-stimulated rat neutrophils, 2-benzyl-3-(4-hydroxymethylphenyl)indazole (CHS-111) inhibited superoxide anion (O(2)(-)) generation, which was not mediated by scavenging the generated O(2)(-) or by a cytotoxic effect, and attenuated migration. CHS-111 had no effect on the arachidonic acid-ind...

journal_title：European journal of pharmacology

authors： Chang LC,Lin RH,Huang LJ,Chang CS,Kuo SC,Wang JP

更新日期：2009-08-01 00:00:00

abstract：:Nitric oxide (NO) plays an important role in the cytotoxic activity of macrophages towards tumour cells and microbial pathogens. We investigated whether alteration of intracellular thiol levels modulates the cytotoxic effects of different NO donors and lipopolysaccharide-induced NO in the murine macrophage cell lin J7...

journal_title：European journal of pharmacology

authors： Zamora R,Matthys KE,Herman AG

更新日期：1997-02-19 00:00:00

abstract：:Recent reports show that the nuclear factor-κB (NF-κB) can control numerous genes encoding inflammatory and nociceptive mediators and play an important role in the development of central pain sensitization. The aim of the present study is to assess the role of NF-κB signal pathway and its downstream pro-inflammatory c...

journal_title：European journal of pharmacology

authors： Sun T,Luo J,Jia M,Li H,Li K,Fu Z

更新日期：2012-05-05 00:00:00

abstract：:Donepezil (E2020) is a novel cholinesterase inhibitor for the treatment of Alzheimer's disease. Recent studies show that it may act on targets other than acetylcholinesterase in the brain. In the present study, the actions of donepezil on voltage-gated Na+ and K+ channels were investigated in rat dissociated hippocamp...

journal_title：European journal of pharmacology

authors： Yu B,Hu GY

更新日期：2005-01-31 00:00:00

abstract：:We have investigated the effects of four fluoroquinolones on the human ether-à-go-go-related gene (HERG) mediated K(+) currents to evaluate their potential to induce QT-prolongation. HERG currents were measured from stably transfected Chinese hamster ovary (CHO) cells by means of the patch-clamp technique. Bath applic...

journal_title：European journal of pharmacology

authors： Bischoff U,Schmidt C,Netzer R,Pongs O

更新日期：2000-10-20 00:00:00

abstract：:Both the gamma-aminobutyric acid (GABA) mimetic, THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol and the serotonergic agonist, MK 212 (6-chloro-2[ 1-piperazinyl ]pyrazine) are effective analgesic agents in the mouse hot plate assay. Naltrexone, however, fails to reverse the analgesia elicited by either compound. ...

journal_title：European journal of pharmacology

authors： Murray TF,McGill W,Cheney DL

更新日期：1983-06-03 00:00:00

abstract：:The effects of omega-conotoxin GVIA (omega-CgTx), a peptide isolated from the venom of a marine mollusc, were studied in rat hippocampal neurons. Intracellular recordings from the CA1 area were made for the purpose in in vitro slice preparations. Omega-CgTx (0.1-1 microM) rapidly and irreversibly blocked the EPSP and ...

journal_title：European journal of pharmacology

authors： Dutar P,Rascol O,Lamour Y

更新日期：1989-12-19 00:00:00

abstract：:The relationship between isometric tension and the increase in cyclic GMP level associated with the initial phase of drug-induced contraction of taenia coli was studied. Maximal contraction induced by 100 micrometers carbachol or 124 mM KCl occurred in 30 sec and was associated with an increase in cyclic GMP levels of...

journal_title：European journal of pharmacology

authors： Janis RA,Diamond J

更新日期：1981-03-12 00:00:00

abstract：:Dose-response curves for morphine (0.5-20 mg/kg) were obtained in 4 rhesus monkeys performing the discrete trials shock titration task. Naloxone (5-500 microgram/kg) uniformly produced a dose dependent, parallel shift of the morphine dose-response curves to right. Plots for the 4 animals of the Log (dose ratio--1) ver...

journal_title：European journal of pharmacology

authors： Yaksh TL,Rudy TA

更新日期：1977-11-15 00:00:00

abstract：:In the guinea-pig ileum, both sarafotoxin S6c and IRL1620 (Suc-[Glu9,Ala11,15]endothelin-1-(8-21) induced a concentration-dependent biphasic effect (relaxation and contraction), but distinct tachyphylaxis of the tissue. Cross-tachyphylaxis and additivity experiments evidenced distinct receptors for these agonists. BQ-...

journal_title：European journal of pharmacology

authors： Miasiro N,Karaki H,Matsuda Y,Paiva AC,Rae GA

更新日期：1999-03-19 00:00:00

abstract：:FACS analysis and [14C]-taurine efflux were used to determine whether activation of the volume-sensitive organic osmolyte/anion channel plays a role in cell cycle progression. This was achieved by examining the effects of a collection of (i) H(1) antagonists and tricyclic antidepressants with a known inhibitory effect...

journal_title：European journal of pharmacology

authors： Belsey MJ,Culliford SJ,Morley RM,Witchel HJ,Kozlowski RZ

更新日期：2003-08-08 00:00:00

abstract：:The (+) and (-) enantiomers of the substituted 2-aminotetralin, N-0437 were evaluated in vivo for their dopaminergic activity, using biochemical as well as behavioural models. In presynaptic models, i.e. antagonism of gamma-butyrolactone-induced dihydroxyphenylalanine elevations and the induction of hypomotility, both...

journal_title：European journal of pharmacology

authors： Van der Weide J,Tendijck ME,Tepper PG,De Vries JB,Dubocovich ML,Horn AS

更新日期：1988-02-09 00:00:00

abstract：:The beta 1- and beta 2-adrenoceptor agonist and thromboxane A2 (TXA2) antagonist properties of trimetoquinol (TMQ, I) and 1-benzyl substituted TMQ analogues [3'-iodo-4',5'-dimethoxy TMQ, II; 3',5'-diiodo-4'-dimethoxy TMQ, III; 3',4'-dimethoxy-5'-nitro TMQ, IV; 3',4'-dimethoxy-5'-amino TMQ; V; and 3',4'-dimethoxy TMQ, ...

journal_title：European journal of pharmacology

authors： Shams G,Romstedt KJ,Gerhardt MA,Harrold MW,Miller DD,Feller DR

更新日期：1990-08-02 00:00:00

abstract：:The aim of the present study was to examine the influence of ifenprodil (a non-competitive NMDA receptor antagonist which also blocks 5-HT3 receptors and alpha1-adrenoceptors) on the effects of ethanol in the mouse in vivo and to elucidate the role of various receptors in these actions. The ethanol (4 g/kg i.p.)-induc...

journal_title：European journal of pharmacology

authors： Malinowska B,Napiórkowska-Pawlak D,Pawlak R,Buczko W,Göthert M

更新日期：1999-07-14 00:00:00

abstract：:The pharmacological profile of YM358, 2,7-diethyl-5-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]tri azole potassium salt monohydrate, a novel non-peptide angiotensin AT1 receptor antagonist, was studied in vitro and in vivo. YM358 competed with [125I][Sar1, Ile8]angiotensin II for angiotensi...

journal_title：European journal of pharmacology

authors： Shibasaki M,Fujimori A,Takanashi M,Kusayama T,Tokioka T,Satoh Y,Okazaki T,Uchida W,Inagaki O,Yanagisawa I

更新日期：1997-09-24 00:00:00

abstract：:Posttraumatic nerve recovery remains a challenge in regenerative medicine. As such, there is a need for agents that limit nerve damage and enhance nerve regeneration. Here we investigate rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase inhibitor, with anti-inflammatory and antioxidant properties...

journal_title：European journal of pharmacology

authors： Abdolmaleki A,Zahri S,Bayrami A

更新日期：2020-09-05 00:00:00

abstract：:(5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3 .2.1]octane (PTAC) is a potent muscarinic receptor ligand with high affinity for central muscarinic receptors and no or substantially less affinity for a large number of other receptors or binding sites including dopamine receptors. The ligand exhibits parti...

journal_title：European journal of pharmacology

authors： Bymaster FP,Shannon HE,Rasmussen K,Delapp NW,Mitch CH,Ward JS,Calligaro DO,Ludvigsen TS,Sheardown MJ,Olesen PH,Swedberg MD,Sauerberg P,Fink-Jensen A

更新日期：1998-09-04 00:00:00