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Ifenprodil influences changes in mouse behaviour related to acute and chronic ethanol administration.

Abstract：

:The aim of the present study was to examine the influence of ifenprodil (a non-competitive NMDA receptor antagonist which also blocks 5-HT3 receptors and alpha1-adrenoceptors) on the effects of ethanol in the mouse in vivo and to elucidate the role of various receptors in these actions. The ethanol (4 g/kg i.p.)-induced sleeping time was shortened by ifenprodil 1 mg/kg but was not affected by ifenprodil 0.3 mg/kg, the 5-HT3 receptor antagonist ondansetron 0.03 mg/kg and the non-competitive NMDA receptor antagonist MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate) 0.01 mg/kg. Ifenprodil 10 mg/kg mimicked the alpha1-adrenoceptor antagonist prazosin 1 mg/kg in that it prolonged the hypnotic response to ethanol (no additive effect when both drugs were given in combination); this is compatible with an involvement of alpha1-adrenoceptors in this effect of ifenprodil. Chronic exposure to ethanol (7%) induced physical dependence. The severity of ethanol withdrawal was suppressed by ifenprodil 1 and 10 mg/kg. In conclusion, ifenprodil influences ethanol-related changes in mouse behaviour and may prove to be useful in the treatment of alcoholism.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Malinowska B,Napiórkowska-Pawlak D,Pawlak R,Buczko W,Göthert M

doi

10.1016/s0014-2999(99)00393-3

keywords:

subject

Has Abstract

pub_date

1999-07-14 00:00:00

pages

13-9

issue

1

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(99)00393-3

journal_volume

377

pub_type

杂志文章

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