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Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors.

Abstract：

:The effect of noradrenaline on 5-hydroxytryptamine (5-HT) release from isolated mouse ileal tissues was investigated. Noradrenaline, but not isoprenaline, at 1 microM stimulated 5-HT release, an effect which was inhibited by yohimbine, an alpha(2)-adrenoceptor antagonist, but not by bunazosin, an alpha(1)-adrenoceptor antagonist. alpha(2)-Adrenoceptor agonists, UK 14,304 (5-bromo-6-(2-imidazolin-2-yl-amino)-quinoxaline) and clonidine at a higher concentration (10 microM) also stimulated 5-HT release, while alpha(1)-adrenoceptor agonists, methoxamine and phenylephrine, had no effect. The effect of noradrenaline was completely abolished in ileal tissues isolated from mouse treated with pertussis toxin (100 microg/kg, i.v.) for 2 days. These results suggest that noradrenaline causes 5-HT release from enterochromaffin cells in mouse ileal tissues via alpha(2)-adrenoceptor subtypes coupled to a pertussis toxin-sensitive G protein.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hirafuji M,Ogawa T,Kato K,Hamaue N,Endo T,Parvez H,Minami M

doi

10.1016/s0014-2999(01)01474-1

keywords:

subject

Has Abstract

pub_date

2001-12-07 00:00:00

pages

149-52

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014299901014741

journal_volume

432

pub_type

杂志文章

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