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Reduction of a centrally induced pressor response by neurohypophyseal peptides: the involvement of lower brainstem mechanisms.

Abstract：

:Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension. Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magnitude of the pressor response. OXT-(7-9) was somewhat more potent than OXT and its effect was dose-dependent. Microinjection of OXT-(7-9) into the dorsal raphe nucleus reduced the pressor response as well. [Arg8]vasopressin (AVP) did not affect the pressor response when administered via this route, while prolyl-arginyl-glycinamide (AVP-(7-9] had an action that was similar to that of OXT-(7-9). None of these peptides affected the magnitude of the bradycardiac response. It is suggested that OXT and related fragments modulate neurogenic hypertensive responses through lower brainstem mechanisms.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Versteeg CA,Cransberg K,De Jong W,Bohus B

doi

10.1016/0014-2999(83)90450-8

subject

Has Abstract

pub_date

1983-10-14 00:00:00

pages

133-40

issue

1-2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(83)90450-8

journal_volume

94

pub_type

杂志文章

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