Abstract：
:To investigate the neurotoxicity of amyloid-beta-(25-35), which is thought to be the active site of amyloid-beta, the peptide was injected into the lateral ventricle of rats. A single intracerebroventricular (i.c.v.) injection of amyloid-beta-(25-35) at a dose of 15 nmol/rat induced a marked decrease in latency in step-through passive avoidance task. Amyloid-beta-(35-25), reverse sequence of amyloid-beta-(25-35), was without harmful effects on passive avoidance performance. The amyloid-beta-(25-35) at a dose of 5 or 15 nmol/rat impaired radial-arm maze performance, and induced a decrease in choline acetyltransferase activity in the medial septum, cortex and hippocampus, but not in the basal forebrain. The number of choline acetyltransferase-immunoreactive cells in the medial septum was decreased, in conformity with the decrease in choline acetyltransferase activity of the area. These results suggest that learning and cognitive disturbance induced by i.c.v. injection of amyloid-beta-(25-35) is associated with the dysfunction of cholinergic neuronal system in the brain.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Yamaguchi Y,Kawashima Sdoi
10.1016/s0014-2999(01)00730-0keywords:
subject
Has Abstractpub_date
2001-02-02 00:00:00pages
265-72issue
3eissn
0014-2999issn
1879-0712pii
S0014299901007300journal_volume
412pub_type
杂志文章abstract：:1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE, PCT: CN02/00412), a novel thioredoxin reductase inhibitor previously synthesized in our lab, has been demonstrated to inhibit the growth of a variety of human cancer cells and to induce apoptosis. Here we report on the potential molecular mechanism of apopt...
journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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