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Evidence for an age-dependent functional expression of alpha 1D-adrenoceptors in the rat vasculature.

Abstract：

:The role of the alpha 1-adrenoceptor subtypes, and their possible change with maturation, in alpha 1-adrenoceptor-induced pressor responses in the rat has not been established. Thus, the effects of the alpha 1D-, alpha 1A/1D- and alpha 1B/1D-adrenoceptor antagonists, BMY 7378 (8-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl) 8-azaspiro (4.5) decane-7,9-dione 2HCl), 5-methyl-urapidil and chloroethylclonidine, respectively, on the pressor responses induced by phenylephrine in 1- and 5-month-old pithed rats were investigated. The pressor responses induced by phenylephrine were competitively antagonized by both BMY 7378 and chloroethylclonidine in 5-month-old, but not in young immature animals; in marked contrast, 5-methylurapidil antagonized with similar potency the phenylephrine-induced pressor responses in animals of both ages. The present pharmacological data suggest that functional expression of alpha 1D-adrenoceptors in the rat resistance vessels increases with age; alpha 1A-, but not alpha 1B- or alpha 1D-adrenoceptors, seem to predominate in immature animals. These findings represent the first evidence that age-related changes in functional alpha 1-adrenoceptor subtypes occur in the systemic vasculature in vivo.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ibarra M,Terrón JA,López-Guerrero JJ,Villalobos-Molina R

doi

10.1016/s0014-2999(97)00092-7

subject

Has Abstract

pub_date

1997-03-19 00:00:00

pages

221-4

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(97)00092-7

journal_volume

322

pub_type

杂志文章

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