The effect of selective noradrenergic lesions upon the stimulation by noradrenaline of inositol phospholipid breakdown in rat hippocampal miniprisms.

abstract：:The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may d...

journal_title：European journal of pharmacology

authors： Stefaniotou A,Varvarousi G,Varvarousis DP,Xanthos T

更新日期：2014-07-05 00:00:00

abstract：:Morphine produced a dose-dependent increase in the activity of dopamine-containing neurons in the substantia nigra and ventral tegmental area recorded from mouse brain slices in vitro. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects are the result of...

journal_title：European journal of pharmacology

authors： Trulson ME,Arasteh K

更新日期：1985-08-07 00:00:00

abstract：:We report the cloning, molecular characterization, and pharmacological characterization of the canine 5-HT2A and 5-HT2B receptors. The canine and human 5-HT2A receptors share 93% amino acid homology. The canine and human 5-HT2B receptors are also highly conserved (87% homology) with the exception of the carboxyl termi...

journal_title：European journal of pharmacology

authors： Bonaventure P,Nepomuceno D,Miller K,Chen J,Kuei C,Kamme F,Tran DT,Lovenberg TW,Liu C

更新日期：2005-04-25 00:00:00

abstract：:Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells...

journal_title：European journal of pharmacology

authors： Jean YH,Chen WF,Duh CY,Huang SY,Hsu CH,Lin CS,Sung CS,Chen IM,Wen ZH

更新日期：2008-01-14 00:00:00

abstract：:This study investigated the characteristics of atrial natriuretic peptide (ANP) release from superfused sliced atria and ventricles of rats. Right atria spontaneously released more immunoreactive ANP (Ir-ANP: pg/min per mg tissue) (32 +/- 3) than did left atria (11 +/- 2) or right ventricles (1.5 +/- 0.5). Addition of...

journal_title：European journal of pharmacology

authors： Zongazo MA,Carayon A,Masson F,Maistre G,Noé E,Eurin J,Barthelemy C,Komajda M,Legrand JC

更新日期：1991-12-10 00:00:00

abstract：:The effects of selective phosphodiesterase inhibitors, cyclic AMP (cAMP) elevating agents and stable analogues of cyclic nucleotides, on the release of arachidonate induced by N-formyl-Met-Leu-Phe (fMLP) were investigated on human peripheral blood mononuclear cells. The selective phosphodiesterase IV inhibitors, rolip...

journal_title：European journal of pharmacology

authors： Hichami A,Boichot E,Germain N,Legrand A,Moodley I,Lagente V

更新日期：1995-10-15 00:00:00

abstract：:Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially inhibit the activity of inducible nitric oxide (NO) synthase with little inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vivo studies to examine its possible appl...

journal_title：European journal of pharmacology

authors： Hattori R,Inoue R,Sase K,Eizawa H,Kosuga K,Aoyama T,Masayasu H,Kawai C,Sasayama S,Yui Y

更新日期：1994-04-15 00:00:00

abstract：:The anticonvulsant effect of cannabinoids has been shown to be mediated through activation of the cannabinoid CB(1) receptor. This study was initiated to evaluate the effects of endogenously occurring cannabinoids (endocannabinoids) on seizure severity and threshold. The anticonvulsant effect of the endocannabinoid, a...

journal_title：European journal of pharmacology

authors： Wallace MJ,Martin BR,DeLorenzo RJ

更新日期：2002-10-11 00:00:00

abstract：:Monoiodo-[125I-Tyr3]neurotensin (NT) bound to a high affinity, low capacity binding component and a lower affinity, high capacity component in rat brain synaptic membranes. The antihistamine H1 agent levocabastine, which bears no structural relationship to NT, selectively and totally inhibited NT binding to its low af...

journal_title：European journal of pharmacology

authors： Kitabgi P,Rostène W,Dussaillant M,Schotte A,Laduron PM,Vincent JP

更新日期：1987-08-21 00:00:00

abstract：:Quantitative receptor autoradiography has been employed to determine the binding distribution of [3H]SR 95531 (2'-(3'-carboxy-2',3'-propyl)-3-amino-6-p-methoxyphenylpyrazinium bromide), a GABAA receptor antagonist, in the rat brain. The location showed good correspondence, in most areas, with the binding of [3H]GABA t...

journal_title：European journal of pharmacology

authors： Bristow DR,Martin IL

更新日期：1988-03-29 00:00:00

abstract：:The influence of GABA-ergic stimulation on the centrally evoked pressor and tachycardic responses to substance P (SP) was investigated in conscious rats. Intracerebroventricular (i.c.v.) pretreatment with the potent GABA agonist muscimol attenuated the pressor responses to i.c.v. administered SP in a dose-dependent an...

journal_title：European journal of pharmacology

authors： Schneider B,Ganten D,Lang RE,Unger T

更新日期：1986-11-12 00:00:00

abstract：:The effects of seganserin, a specific 5HT2 antagonist, on human sleep were assessed in two experiments and compared to the effects of temazepam and sleep deprivation. During daytime recovery sleep after sleep deprivation, seganserin did not significantly enhance visually scored slow wave sleep (SWS, stages 3 + 4) or t...

journal_title：European journal of pharmacology

authors： Dijk DJ,Beersma DG,Daan S,van den Hoofdakker RH

更新日期：1989-11-21 00:00:00

abstract：:The in vivo cardiovascular effect and in vitro vasorelaxant effect of harman, one of harmala alkaloids isolated from Peganum harmala, were examined in this study. Harman (1-10 mg/kg, i.v.) dose-dependently produced transient hypotension and long-lasting bradycardia in pentobarbital-anesthetized rats, which were attenu...

journal_title：European journal of pharmacology

authors： Shi CC,Chen SY,Wang GJ,Liao JF,Chen CF

更新日期：2000-03-03 00:00:00

abstract：:Antagonists, but not agonists, of the 5-HT3 receptor are useful therapeutic agents, and it is possible that partial agonists may also be potentially useful in the clinic. Here we show that 5-fluorotryptamine (5-FT) is a partial agonist at both 5-HT3A and 5-HT3AB receptors with an Rmax (Imax/Imax 5-HT) of 0.64 and 0.45...

journal_title：European journal of pharmacology

authors： Bower KS,Price KL,Sturdee LE,Dayrell M,Dougherty DA,Lummis SC

更新日期：2008-02-12 00:00:00

abstract：:The site of the analgesic action of AD-1211, the less active stereoisomer, and its pharmacological features were investigated. AD-1211, as well as pentazocine and morphine, blocked the reflex hypertension caused by injection of both bradykinin and bradykinin plus PGE1 into the splenic artery of dogs. In the rat or mou...

journal_title：European journal of pharmacology

authors： Nakamura H,Ishii K,Yokoyama Y,Imazu C,Shimoda A,Kadokawa T,Shimizu M

更新日期：1984-11-13 00:00:00

abstract：:A specific binding site for the antiepileptic drug levetiracetam (2S-(oxo-1-pyrrolidinyl)butanamide, Keppra) in rat brain, referred to as the levetiracetam binding site, was discovered several years ago. More recently, this binding site has been identified as the synaptic vesicle protein 2A (SV2A), a protein present i...

journal_title：European journal of pharmacology

authors： Gillard M,Chatelain P,Fuks B

更新日期：2006-04-24 00:00:00

abstract：:Restraint for 1 h induced significant antinociceptive activity, as assessed by the hot plate test, in female mice. The antinociceptive activity was significant throughout the 1 h period of observation starting immediately after restraint. Prior administration of the histamine H2 receptor agonist dimaprit (1.5-6.0 mg/k...

journal_title：European journal of pharmacology

authors： Wong CL

更新日期：1995-06-12 00:00:00

abstract：:Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimu...

journal_title：European journal of pharmacology

authors： Marin MT,Zancheta R,Paro AH,Possi AP,Cruz FC,Planeta CS

更新日期：2011-06-25 00:00:00

abstract：:Acute lung injury (ALI) is a common severe clinical syndrome in intensive care unit. Inflammation has been reported to play a critical role in the development of ALI. Cordycepin, an active component isolated from Cordyceps militaris, has been reported to have anti-inflammatory effects. However, the anti-inflammatory e...

journal_title：European journal of pharmacology

authors： Lei J,Wei Y,Song P,Li Y,Zhang T,Feng Q,Xu G

更新日期：2018-01-05 00:00:00

abstract：:3-(Benzo[b]furan-5-yl)-2', 6'-dihydroxy-4'-methylpropiophenone-2'-O-(6-O-methoxycarbonyl)-bet a-D -glucopyranoside (T-1095) is a derivative of phlorizin, a potent inhibitor of Na(+)-glucose cotransporters. We determined the antidiabetic effect of T-1095 in neonatally streptozotocin-treated diabetic rats. Orally admini...

journal_title：European journal of pharmacology

authors： Oku A,Ueta K,Nawano M,Arakawa K,Kano-Ishihara T,Matsumoto M,Saito A,Tsujihara K,Anai M,Asano T

更新日期：2000-03-10 00:00:00

abstract：:Inhaled corticosteroids (ICS) are recommended treatments for all degrees of asthma severity and in combination with bronchodilators are indicated for COPD patients with a history of frequent exacerbations. However, the long-term side effects of glucocorticoids (GCs) may include increased risk of respiratory infections...

journal_title：European journal of pharmacology

authors： Marcellini A,Swieboda D,Guedán A,Farrow SN,Casolari P,Contoli M,Johnston SL,Papi A,Solari R

更新日期：2021-02-15 00:00:00

abstract：:We investigated the effect of probucol, a lipid-lowering agent with antioxidant properties, on HCl plus ethanol-induced gastric mucosal injury and on the healing of acetic acid-induced gastric ulcers in rats. When the free radical-scavenging activity of probucol was measured by an electron spin resonance technique, th...

journal_title：European journal of pharmacology

authors： Ito M,Suzuki Y,Ishihara M,Suzuki Y

更新日期：1998-08-07 00:00:00

abstract：:Experiments were undertaken to determine the effect of the selective histamine H3 receptor agonist (R)-alpha-methylhistamine on the amplitude of neurally evoked electrodermal (sudomotor) responses in anesthetized cats. (R)-alpha-Methylhistamine produced comparable dose-related depressions of these evoked sympathetic-c...

journal_title：European journal of pharmacology

authors： Koss MC

更新日期：1994-05-12 00:00:00

abstract：:With age an increase in prostatic smooth muscle tone mediated by α1L-adrenoceptors contributes to the lower urinary tract symptoms associated with benign prostatic hyperplasia. Current treatments for benign prostatic hyperplasia include α1-adrenoceptor antagonists which inhibit smooth muscle contraction. However, musc...

journal_title：European journal of pharmacology

authors： White CW,Short JL,Ventura S

更新日期：2013-12-05 00:00:00

abstract：:A major challenge in translational research is to reduce the currently high proportion of new candidate treatment agents for neuroinflammatory disease, which fail to reproduce promising effects observed in animal models when tested in patients. This disturbing situation has raised criticism against the currently used ...

journal_title：European journal of pharmacology

authors： 't Hart BA

更新日期：2015-07-15 00:00:00

abstract：:The peptides for-Met-Leu-Tyr-OMe, for-Met-Leu-Glu-OMe, for-Met-Leu-Asp-OMe and for-Met-Leu-Ser-OMe were synthesized to investigate the importance of a hydrophilic side chain of the residue at position 3 on biological activities of human neutrophils. A number of in vitro essays were carried out, including: chemotaxis, ...

journal_title：European journal of pharmacology

authors： Spisani S,Turchetti M,Varani K,Falzarano S,Cavicchioni G

更新日期：2003-05-23 00:00:00

abstract：:Chloranolol (5 mg/kg i.p.) retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.) was effective only in the hy...

journal_title：European journal of pharmacology

authors： Simonyi A,Kanyicska B,Szentendrei T,Fekete MI

更新日期：1984-02-17 00:00:00

abstract：:Compared with sham-operated guinea pigs, chronic heart failure produced by aortic constriction resulted in a 79% increase in alpha 1-adrenoceptor density as measured by [3H]prazosin binding (73 +/- 15 vs. 131 +/- 20 fmol/mg protein, P < 0.05); beta-adrenoceptor number, measured by (-)-[3H]dihydroalprenolol binding, in...

journal_title：European journal of pharmacology

authors： Karliner JS,Barnes P,Brown M,Dollery C

更新日期：1980-10-03 00:00:00

abstract：:The release of bladder-derived relaxant factor in a coaxial bioassay system and the effects of reactive oxygen species were studied. After precontraction with phenylephrine (10(-6)-3x10(-6)) or 50 mM K+, acetylcholine (10(-8)-10(-3) M) induced relaxation in rat anococcygeus muscle mounted within rat bladder in a tissu...

journal_title：European journal of pharmacology

authors： Bozkurt TE,Sahin-Erdemli I

更新日期：2004-07-14 00:00:00

abstract：:Right ventricular papillary muscles of the guinea-pig heart were electrically stimulated. Cromakalim 10-100 microM and Ro 31-6930 3 microM depressed the contractile force and shortened the duration of action potentials. Glibenclamide 0.3-3 microM, ATP 100 microM and alpha, beta-methylene ATP (alpha, beta-meATP) 30 mic...

journal_title：European journal of pharmacology

authors： Bott A,Eltze M,Illes P

更新日期：1992-03-17 00:00:00