Chronic heart failure in the guinea pig increases cardiac alpha 1- and beta-adrenoceptors.

abstract：:Mice, subjected footshock, showed a significant increase of pain threshold and motor suppression immediately after the footshock and both effects were partially antagonized by pretreatment with naloxone at high doses. The magnitude of footshock-induced analgesia, but not motor suppression, was significantly less in mo...

journal_title：European journal of pharmacology

authors： Nabeshima T,Yamada K,Kameyama T

更新日期：1983-09-02 00:00:00

abstract：:Pentoxifylline, a methylxanthine derivative, has been widely used to improve erythrocyte deformability and capillary blood circulation in patients with claudication and cerebrovascular disorders as well as in animals with sepsis. Here, we investigate the effects of pentoxifylline on the hypotension, vascular hyporeact...

journal_title：European journal of pharmacology

authors： Wu CC,Liao MH,Chen SJ,Yen MH

更新日期：1999-05-28 00:00:00

abstract：:This study examined alterations in the beta-adrenoceptor-G5-adenylyl cyclase system in cerebral cortex membranes from vitamin B12-deficient rats fed a diet lacking vitamin B12 (mecobalamin) for 15 weeks. Basal, 5(7)-guanylylimidodiphosphate (GppNHp)-, isoproterenol-, and forskolin-stimulated adenylyl cyclase activitie...

journal_title：European journal of pharmacology

authors： Hatta S,Watanabe M,Ikeda H,Kamada H,Saito T,Ohshika H

更新日期：1995-11-30 00:00:00

abstract：:Recent studies suggested the involvement of the endocannabinoid pathway on insulin secretion in RINm5F cells or rat islets. Animal and clinical studies have reported beneficial effects of the selective cannabinoid 1 receptor antagonist rimonabant on glucose homeostasis. The aim of this study was to investigate the in ...

journal_title：European journal of pharmacology

authors： Duvivier VF,Delafoy-Plasse L,Delion V,Lechevalier P,Le Bail JC,Guillot E,Pruniaux MP,Galzin AM

更新日期：2009-08-15 00:00:00

abstract：:The aim of the study was to assess which tachykinin receptors mediate the contractile response in the guinea-pig isolated bronchi. Experiments with natural tachykinins and receptor-selective tachykinin agonists were performed in the absence or presence of peptidase inhibitors and in bronchi pretreated with phenoxybenz...

journal_title：European journal of pharmacology

authors： Maggi CA,Patacchini R,Quartara L,Rovero P,Santicioli P

更新日期：1991-05-17 00:00:00

abstract：:In this study, we investigated whether spinal noradrenergic and serotonergic systems are involved in the antinociception induced by the novel pyrazolines 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-1-pyrazole-1-carboxyamide (MPCA and PPCA, respectively), and the pyrazolinone dipyrone in the aceti...

journal_title：European journal of pharmacology

authors： Godoy MC,Fighera MR,Souza FR,Flores AE,Rubin MA,Oliveira MR,Zanatta N,Martins MA,Bonacorso HG,Mello CF

更新日期：2004-08-02 00:00:00

abstract：:Previous studies have shown that sertindole (1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl ]-2 imidazolidinone), an atypical antipsychotic drug that is a potent 5-HT2A and dopamine D2 receptor antagonist, preferentially affects mesocorticolimbic rather than mesostriatal dopamine neurons. Usin...

journal_title：European journal of pharmacology

authors： Watanabe M,Hagino Y

更新日期：1999-02-12 00:00:00

abstract：:SQ 20009 and SQ 65396, two new pyrazolopyridines with anxiolytic properties in animals, reversibly increased Na+-independent 3H-GABA binding to rat cerabral cortex membranes in vitro. This modulation was partially chloride dependent and sensitive to Triton-X 100. Kinetic analysis of 3H-muscimol binding revealed an inc...

journal_title：European journal of pharmacology

authors： Placheta P,Karobath M

更新日期：1980-03-21 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are the largest superfamily of potassium (K) channels. A variety of Kv channels are expressed in the vascular smooth muscle cells (SMC). Studies have shown that gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) cause various changes in the human umbilica...

journal_title：European journal of pharmacology

authors： Djokic V,Jankovic S,Labudovic-Borovic M,Rakocevic J,Stanisic J,Rajkovic J,Novakovic R,Kostic M,Djuric M,Gostimirovic M,Gojkovic-Bukarica L

更新日期：2020-09-05 00:00:00

abstract：:A very strong epidemiological link exists between obesity, the metabolic syndrome, diabetes and diabetes-associated cardiovascular pathologies. For this reason the peripheral effects of the centrally-acting satiety adipokines, adiponectin and leptin, and of non-adipose-derived hormones with similar effects, like ghrel...

journal_title：European journal of pharmacology

authors： Elbatarny HS,Netherton SJ,Ovens JD,Ferguson AV,Maurice DH

更新日期：2007-03-08 00:00:00

abstract：:The inhibition of the tail-flick response induced by beta-endorphin given i.c.v. has been demonstrated to be mediated by the stimulation of epsilon- but not mu-, delta- or kappa-opioid receptors. beta-Endorphin given i.t. also inhibited the tail-flick response. The present studies were designed to determine what types...

journal_title：European journal of pharmacology

authors： Tseng LF,Collins KA

更新日期：1992-04-07 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have been shown great potential for cardiac regeneration. However the therapeutic efficiency has become a major obstacle due to the poor survival of transplanted MSCs in ischemic cardiac tissue. Previous studies reported that melatonin could protect many different types of cel...

journal_title：European journal of pharmacology

authors： Wang F,Zhou H,Du Z,Chen X,Zhu F,Wang Z,Zhang Y,Lin L,Qian M,Zhang X,Li X,Hao A

更新日期：2015-02-05 00:00:00

abstract：:The muscarinic agonist McN-A-343 did not affect the tone or nitroprusside-induced relaxations of the rat anococcygeus, but inhibited non-adrenergic non-cholinergic (NANC) relaxations. Atropine, pirenzepine and gallamine blocked the McN-A-343 inhibition of NANC relaxations. Agonists of alpha 1-(methoxamine) or alpha 2-...

journal_title：European journal of pharmacology

authors： Li CG,Rand MJ

更新日期：1989-09-01 00:00:00

abstract：:Growing evidence supports involvement of low-affinity/high-capacity organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in regulating clearance of monoamines. Currently decynium-22 (D22) is the best pharmacological tool to study these transporters, however it does not readily discrimina...

journal_title：European journal of pharmacology

authors： Fraser-Spears R,Krause-Heuer AM,Basiouny M,Mayer FP,Manishimwe R,Wyatt NA,Dobrowolski JC,Roberts MP,Greguric I,Kumar N,Koek W,Sitte HH,Callaghan PD,Fraser BH,Daws LC

更新日期：2019-01-05 00:00:00

abstract：:Rats were treated with ethanol in the drinking fluid 2 X 1 h daily for 83 weeks. [3H]Muscimol, [3H]quinuclidinyl benzilate ( [3H]QNB) and [3H]nicotine binding was measured in selected brain areas 7, 14 and 21 days after withdrawal of ethanol. A significant increase (P less than 0.05) when compared to controls was foun...

journal_title：European journal of pharmacology

authors： Nordberg A,Wahlström G,Eriksson B

更新日期：1985-09-24 00:00:00

abstract：:In the present report, we studied the distribution of the imidazoline-guanidinium receptive site in mitochondrial fractions from different rabbit and human tissues. Binding studies of the imidazoline-guanidinium receptive site ligand [3H]idazoxan, allowed to distinguish two groups of tissues: the first one, including ...

journal_title：European journal of pharmacology

authors： Tesson F,Limon I,Parini A

更新日期：1992-08-25 00:00:00

abstract：:Our goal was to determine if venlafaxine has a negative effect on bone metabolism. Rats were divided into three groups. The sham-operated control group (SHAM), the control group after orchidectomy (ORX), and the experimental group after orchidectomy received venlafaxine (VEN ORX) in standard laboratory diet (SLD) for ...

journal_title：European journal of pharmacology

authors： Fekete S,Simko J,Mzik M,Karesova I,Zivna H,Zivny P,Pavliková L,Palicka V

更新日期：2015-08-15 00:00:00

abstract：:Peripheral electrical stimulation of the rat produced a "dose-dependent" analgesia both in intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed this analgesia. It is felt that peripheral electroanalgesia acts via the release of endogenous narcotic-like substances, the enkephalins, ...

journal_title：European journal of pharmacology

authors： Woolf CJ,Barrett GD,Mitchell D,Myers RA

更新日期：1977-10-01 00:00:00

abstract：:3H-angiotensin binding sites have been studied in a particulate fraction prepared from rat adrenal glands. This binding is rapid and reversible, of high affinity (KD29 degrees C = 3-5 X 10(-9) M) and with demonstrable specificity for the angiotensin II octapeptide. The number of binding sites varies with endogenous an...

journal_title：European journal of pharmacology

authors： Pernollet MG,Devynck MA,Matthews PG,Meyer P

更新日期：1977-06-15 00:00:00

abstract：:This study showed the effects of baclofen on endogenous excitatory (Glu and Asp) and non-excitatory (Tau, Gly and Ala) amino acid release. (A) Release was stimulated by K+ 30 mM in rat frontal cortex slices in vitro (evoked release in ng/g tissue per 5 min): 3739 +/- 215 (Asp), 3429 +/- 357 (Glu), 763 +/- 181 (Tau), 9...

journal_title：European journal of pharmacology

authors： Losada ME,Acosta GB

更新日期：1992-11-24 00:00:00

abstract：:Effects of the 5-HT3 receptor agonist, m-chlorophenylbiguanide (10.0-40.0 microg), on sleep and waking were studied in control, vehicle-treated and 6-hydroxydopamine-injected rats. Bilateral injections of m-chlorophenylbiguanide into the nucleus accumbens of the control and the vehicle-infused animals significantly in...

journal_title：European journal of pharmacology

authors： Monti JM,Ponzoni A,Jantos H,Lagos P,Silveira R,Banchero P

更新日期：1999-01-08 00:00:00

abstract：:The temporal effect of (R)-alpha-methylhistamine on epithelial cell proliferation throughout the rat gastrointestinal tract was investigated. (R)-alpha-methylhistamine was administered at 100 mg/kg orally and the rats were sacrificed 1, 24, 48, 72 and 144 h later. All the animals received 5-bromo-2'-deoxyuridine, (Brd...

journal_title：European journal of pharmacology

authors： Grandi D,Schunack W,Morini G

更新日期：2006-05-24 00:00:00

abstract：:The purpose of the present study was to test whether kava extract and its constituents kawain, dihydrokawain, methysticin, dihydromethysticin and yangonin provide protection against ischemic brain damage. To this end, we used a model of focal cerebral ischemia in mice and rats. Ischemia was induced by microbipolar coa...

journal_title：European journal of pharmacology

authors： Backhauss C,Krieglstein J

更新日期：1992-05-14 00:00:00

abstract：:Several experiments were conducted to study the effects of established or potential antiparkinsonian drugs on the tremulous jaw movements induced by the anticholinesterase tacrine (9-amino-1,2,3,4-tetrahydroaminoacridine hydrochloride). In the first group of four experiments, separate groups of animals that received 2...

journal_title：European journal of pharmacology

authors： Cousins MS,Carriero DL,Salamone JD

更新日期：1997-03-19 00:00:00

abstract：:The potentiation of the toxic and lethal effects of cocaine by the selective delta-opioid receptor antagonist naltrindole was explored in unrestrained, unanesthetized rats that received a continuous intravenous infusion of cocaine until death. The lethal dose of cocaine was lowered dose dependently in animals administ...

journal_title：European journal of pharmacology

authors： Patterson AB,Gordon FJ,Holtzman SG

更新日期：1997-08-20 00:00:00

abstract：:R-isovaline is a non-proteinogenic amino acid which produces analgesia in a range of nociceptive assays. Mediation of this effect by metabotropic receptors for γ-aminobutyric acid (GABA) and glutamate, demonstrated by previous work, may depend on the type of tissue or receptor system. The objective of this study was t...

journal_title：European journal of pharmacology

authors： Fung T,Asseri KA,Asiri YI,Wall RA,Schwarz SKW,Puil E,MacLeod BA

更新日期：2016-11-15 00:00:00

abstract：:In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT ...

journal_title：European journal of pharmacology

authors： Donzanti BA,Warwick RO

更新日期：1979-10-26 00:00:00

abstract：:Some reports published from 1967 to 1999 describe the use of ointments containing high doses (0.1 to 0.2%, w/w) C. asiataica herb extracts to enhance wound repair. Lower doses at which burn wound repair is enhanced by such topical applications have not been established yet. We found that the application of asiaticosid...

journal_title：European journal of pharmacology

authors： Kimura Y,Sumiyoshi M,Samukawa K,Satake N,Sakanaka M

更新日期：2008-04-28 00:00:00

abstract：:[3H]Zolpidem, a novel hypnotic drug possessing a chemical structure unrelated to that of benzodiazepine (BZD) was employed as a new ligand to determine its binding characteristics to membrane preparations of rat cerebral cortex and cerebellum. In both structures, the imidazopyridine [3H]zolpidem bound with high affini...

journal_title：European journal of pharmacology

authors： Arbilla S,Allen J,Wick A,Langer SZ

更新日期：1986-11-04 00:00:00

abstract：:Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this study, tryptase was evaluated for its ability to induce microvascular leakage into the airways of guinea pigs. Dose- and time-dependent increases in airway mic...

journal_title：European journal of pharmacology

authors： Greenfeder S,Sehring S,McHugh N,Corboz M,Rivelli M,Anthes JC,Billah M,Egan RW,Chapman RW

更新日期：2001-05-11 00:00:00