Abstract:
:In the present report, we studied the distribution of the imidazoline-guanidinium receptive site in mitochondrial fractions from different rabbit and human tissues. Binding studies of the imidazoline-guanidinium receptive site ligand [3H]idazoxan, allowed to distinguish two groups of tissues: the first one, including kidney, brain and liver, displays a high density of imidazoline-guanidinium receptive site; the second one, consisting of striated and smooth muscle, enterocytes, lung, spleen and heart, is characterized by 4- to 16-fold lower binding site density. The demonstration that mitochondrial imidazoline-guanidinium receptive sites are not equally expressed in all tissues can be considered as a further progress towards the characterization of their functional activity.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Tesson F,Limon I,Parini Adoi
10.1016/0014-2999(92)90316-vkeywords:
subject
Has Abstractpub_date
1992-08-25 00:00:00pages
335-8issue
2eissn
0014-2999issn
1879-0712pii
0014-2999(92)90316-Vjournal_volume
219pub_type
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