Abstract:
:Sensitization to the discriminative stimulus effects of psychostimulants is not fully understood. Therefore, the present study was designed to investigate the development of sensitization to the discriminative stimulus of methamphetamine in rats. A dose-response curve for methamphetamine and a generalization test for cocaine were recorded in rats trained to discriminate between 1.0 mg/kg methamphetamine and saline. A significant leftward shift of the dose-response curve for methamphetamine and of the dose-generalization curve for cocaine was observed following repeated administration of methamphetamine (2.0 mg/kg) instead of saline. These findings suggest that repeated administration of methamphetamine can produce behavioral sensitization to the discriminative stimulus effects of methamphetamine in rats.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Suzuki T,Fukuoka Y,Mori T,Miyatake M,Narita Mdoi
10.1016/j.ejphar.2004.07.064keywords:
subject
Has Abstractpub_date
2004-09-13 00:00:00pages
157-61issue
1-3eissn
0014-2999issn
1879-0712pii
S0014-2999(04)00797-6journal_volume
498pub_type
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