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Increase in nigral type II benzodiazepine recognition sites following striatonigral denervation.

Abstract：

:In the rat substantia nigra Type II benzodiazepine recognition sites (measured as the portion of [3H]flunitrazepam binding which remain after the addition of 2 X 10(-7) M Cl 218872) represent 50% of the total benzodiazepine recognition sites. The density of Type II sites was increased by 35% following the degeneration of the striatonigral afferents induced by the intrastriatal injection of kainic acid. On the other hand the same lesion failed to change the density of the remaining nigral Type I sites. The results indicate that denervation induces supersensitivity to nigral Type II benzodiazepine recognition sites.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Porceddu ML,Corda MG,Sanna E,Biggio G

doi

10.1016/0014-2999(85)90507-2

subject

Has Abstract

pub_date

1985-06-07 00:00:00

pages

265-7

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(85)90507-2

journal_volume

112

pub_type

杂志文章

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