Abstract:
:The influence of GABA-ergic stimulation on the centrally evoked pressor and tachycardic responses to substance P (SP) was investigated in conscious rats. Intracerebroventricular (i.c.v.) pretreatment with the potent GABA agonist muscimol attenuated the pressor responses to i.c.v. administered SP in a dose-dependent and reversible fashion. Inhibition was maximal 5-60 min after muscimol injection and lasted up to 3 h. In contrast, the increases in heart rate in response to i.c.v. administered SP were not consistently inhibited by muscimol. Central pretreatment with muscimol prevented the increase of plasma adrenaline but not of plasma noradrenaline in response to i.c.v. administered SP. Our results demonstrate that the GABA-ergic system can exert an inhibitory control on pathways mediating the central pressor actions of SP. The selective inhibition of adrenaline secretion by muscimol implies that suppression of sympathetic outflow to the adrenal gland may be involved as an important mechanism. In addition, our findings point to a dissociation between pathways mediating the pressor and tachycardic effects of SP.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Schneider B,Ganten D,Lang RE,Unger Tdoi
10.1016/0014-2999(86)90512-1subject
Has Abstractpub_date
1986-11-12 00:00:00pages
31-7issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(86)90512-1journal_volume
131pub_type
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