Homologous vs. heterologous desensitization of the adenylate cyclase system in heart cells.

abstract：:Subplantar injection of 0.10 micrograms of serotonin in the rat resulted in a brief period (0-20 min) of increased pain sensitivity to an applied force (hyperalgesia) which preceded a longer period (40-120 min) of decreased pain sensitivity (hypoalgesia). The magnitude of each of these changes and the duration of the ...

journal_title：European journal of pharmacology

authors： Vinegar R,Truax JF,Selph JL,Johnston PR

更新日期：1989-05-30 00:00:00

abstract：:We examined the effects of intrarenal infusion of EXP3174, a non-peptide angiotensin II receptor antagonist, in order to evaluate the physiological role of endogenous angiotensin II in regulating renal hemodynamics and urine formation and to assess the possibility of a tubular site(s) of action of endogenous angiotens...

journal_title：European journal of pharmacology

authors： Tamaki T,Nishiyama A,Yoshida H,He H,Fukui T,Yamamoto A,Aki Y,Kimura S,Iwao H,Miyatake A

更新日期：1993-05-12 00:00:00

abstract：:Activation of imidazoline receptors in the central nervous system has protective effect on several types of arrhythmias. We demonstrated that centrally administered rilmenidine, a selective imidazoline receptor agonist, prevented adrenaline-induced arrhythmias during halothane anaesthesia. However, detailed myocardial...

journal_title：European journal of pharmacology

authors： Yamanaka H,Hayashi Y,Iwasaki M,Kamibayashi T,Yamatodani A,Mashimo T

更新日期：2010-11-25 00:00:00

abstract：:We have previously reported that 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of arachidonic acid by 15-lipoxygenase, causes pulmonary vasoconstriction via increasing the intracellular Ca(2+) concentration ([Ca(2+)]i). However, the multiple sources of Ca(2+) that contribute to Ca(2+) elevation during and af...

journal_title：European journal of pharmacology

authors： Zheng X,Li Q,Tang X,Liang S,Chen L,Zhang S,Wang Z,Guo L,Zhang R,Zhu D

更新日期：2008-12-28 00:00:00

abstract：:In isolated rabbit aortae, imidazole (10(-4)M) caused a unique nonspecific potentiation of the contractile responses to prostaglandins, norepinephrine, 5-hydroxytryptamine, histamine and potassium only at low concentrations. Imidazole had no effect on the dose-response relationship for Ca2+ in the presence of potassiu...

journal_title：European journal of pharmacology

authors： Suzuki Y,Ishida Y,Hester RK,Shibata S

更新日期：1982-09-24 00:00:00

abstract：:The effects of cytosolic ATP on Ca2+-dependent K+ (K(Ca)) channel activation in cultured bovine adrenal chromaffin cells were investigated by using single-channel recording patch-clamp techniques. Application of ATP to the intracellular surface of excised inside-out patches activated K(Ca) channels in a dose-dependent...

journal_title：European journal of pharmacology

authors： Chen C,Houchi H,Tamaki T,Nakaya Y

更新日期：1998-06-05 00:00:00

abstract：:Phasic release of calcium from the sarcoplasmic reticulum occurs in all mammalian cardiac preparations when the intracellular calcium concentration is sufficiently high. The phasic calcium release is often sufficient to trigger electrophysiological responses and aftercontractions. These can be detrimental to normal ca...

journal_title：European journal of pharmacology

authors： Briggs GM,Morgan JP,Gwathmey JK

更新日期：1989-11-07 00:00:00

abstract：:The influence of endothelin-1 on nociception induced by capsaicin was assessed in the mouse hindpaw. Local endothelin-1 injection (1 to 20 pmol/paw) 30 min prior to ipsilateral injection of capsaicin (0.1 microg/paw) increased, in a graded fashion, the time spent licking the injected paw. Maximal hyperalgesia was obta...

journal_title：European journal of pharmacology

authors： Piovezan AP,D'Orléans-Juste P,Tonussi CR,Rae GA

更新日期：1998-06-12 00:00:00

abstract：:Bupropion is a weakly potent central nervous system (CNS) stimulant that is marketed both as an antidepressant and as an anti-smoking aid. The mechanism(s) by which it produces its effects is not well understood. In the present study, the effect of bupropion was examined in rats trained to discriminate the stimulus ef...

journal_title：European journal of pharmacology

authors： Young R,Glennon RA

更新日期：2002-05-17 00:00:00

abstract：:Stimulation of muscarinic M1-receptors in isolated rabbit vas deferens by McN-A-343 inhibited electrically induced twitch contractions susceptible to competitive blockade by (+)-, (+/-), (-)-telenzepine and pirenzepine (pA2 = 9.12, 8.86, 6.98 and 7.79, respectively). The inhibition of twitch contractions by 10(-6) M M...

journal_title：European journal of pharmacology

authors： Eltze M

更新日期：1990-05-03 00:00:00

abstract：:Dietary fish oils rich in n-3 polyunsaturated fatty acids can modulate a diverse range of factors contributing to cardiovascular disease. This study examined the relative roles of eicosapentaenoic acid (20:5 n-3; EPA) and docosahexaenoic acid (22:6 n-3; DHA) which are the principal n-3 polyunsaturated fatty acids rega...

journal_title：European journal of pharmacology

authors： McLennan P,Howe P,Abeywardena M,Muggli R,Raederstorff D,Mano M,Rayner T,Head R

更新日期：1996-04-04 00:00:00

abstract：:Elevated fatty acid levels play a pathogenic role in the development of insulin resistance, associated with type 2 diabetes. Interventions with ability to ameliorate fatty acid-induced insulin resistance might be useful for the management of diabetes. Here, we explored the effect of the diastereomeric mixture of calop...

journal_title：European journal of pharmacology

authors： Jaiswal N,Gunaganti N,Maurya CK,Narender T,Tamrakar AK

更新日期：2015-01-05 00:00:00

abstract：:NP-252, a new dihydropyridine derivative, and nifedipine non-competitively inhibited contractile responses to KCl and responses to Ca2+ in Ca(2+)-free medium containing KCl in rabbit aorta and renal, mesenteric, coronary and basilar arteries, mesenteric veins and vena cava. The effects of NP-252 in these smaller arter...

journal_title：European journal of pharmacology

authors： Shibata S,Satake N,Kodama I,Hester RK,Wang CG,Jino H,Hojo M,Tatsumi H,Gandhi V,Jones DJ

更新日期：1991-10-22 00:00:00

abstract：:The effects of conditioned fear on gross activity, heart rate, PQ interval, noradrenaline and adrenaline were studied in freely moving rats. Subcutaneous (s.c.) injections of atropine methyl nitrate (0.5 mg/kg) during rest resulted in a significant shortening of the PQ interval, indicating that the PQ interval can be ...

journal_title：European journal of pharmacology

authors： Nijsen MJ,Croiset G,Diamant M,Stam R,Delsing D,de Wied D,Wiegant VM

更新日期：1998-06-05 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Despite the impact of this pathology in the population, nowadays there is no specific treatment for this disease, focusing its treatment on risks factors. However, it is imperative the existence of a specific treatment, due to this...

journal_title：European journal of pharmacology

authors： de Jesús Acosta-Cota S,Aguilar-Medina EM,Ramos-Payán R,Rendón Maldonado JG,Romero-Quintana JG,Montes-Avila J,Sarmiento-Sánchez JI,Plazas-Guerrero CG,Vergara-Jiménez MJ,Sánchez-López A,Centurión D,Osuna-Martínez U

更新日期：2019-11-15 00:00:00

abstract：:Cumulative dose-response curves of Ca2+-induced tension increments were studied in K+-depolarized helical strips of dog coronary arteries. Adenosine 10(-4) M reduced the Ca2+ sensitivity of the strips without altering the maximal tension with full Ca2+ activation. In contrast, acidosis of pH 7.05 significantly diminis...

journal_title：European journal of pharmacology

authors： Turnheim K,Pittner H,Kolassa N,Kraupp O

更新日期：1977-01-21 00:00:00

abstract：:To identify the site of action of opiate-induced prolactin elevation, in vitro rat hemipituitary incubations were performed in the presence of morphine, met-enkephalin, ala2-met5-enkephalinamide and dopamine (DA) and combinations of opiate with the catecholamine. No opiate stimulated prolactin release directly nor did...

journal_title：European journal of pharmacology

authors： Login IS,Macleod RM

更新日期：1979-12-07 00:00:00

abstract：:The general anaesthetic ketamine affects the central cholinergic system in several manners, but its effect on spinal acetylcholine release, which may be an important transmitter in spinal antinociception, is unknown. This study aimed to investigate the effect of ketamine on spinal acetylcholine release. Microdialysis ...

journal_title：European journal of pharmacology

authors： Abelson KS,Goldkuhl RR,Nylund A,Höglund AU

更新日期：2006-03-18 00:00:00

abstract：:Melatonin is of considerable interest for its regulatory influence on a variety of physiological processes including biological rhythms and neuroendocrine functions. We showed that melatonin potentiates sympathetic neurotransmission in the prostatic portion of the rat vas deferens, by increasing contractions in respon...

journal_title：European journal of pharmacology

authors： Carneiro RC,Toffoleto O,Cipolla-Neto J,Markus RP

更新日期：1994-05-12 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:Prostaglandin E2 (PGE2) is a prostanoid with diverse actions in health and disease. In chronic respiratory diseases driven by inflammation, PGE2 has both positive and negative effects. An enhanced understanding of the receptor-mediated cellular signalling pathways induced by PGE2 may help us separate the beneficial pr...

journal_title：European journal of pharmacology

authors： Rumzhum NN,Ammit AJ

更新日期：2016-07-05 00:00:00

abstract：:Wasp venoms contain several active components, among them kinin-related peptides. Like bradykinin and [Thr6]bradykinin, Vespula vulgaris venom caused paw oedema following subplantar injection in anaesthetized rats. The oedema was partly inhibited by the bradykinin B2 receptor antagonist icatibant (Hoe 140); the remain...

journal_title：European journal of pharmacology

authors： Griesbacher T,Althuber P,Zenz M,Rainer I,Griengl S,Lembeck F

更新日期：1998-06-12 00:00:00

abstract：:The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge of catecholamines. Recovery of the labelled decapeptide and metabolites in the adrenal effluent fluid was complete in 5 min. Radioimmunoassay of this perfusate revealed that most of the peptide re...

journal_title：European journal of pharmacology

authors： Ackerly JA,Felger TS,Peach MJ

更新日期：1976-07-01 00:00:00

abstract：:5-HT(1A) receptor activation by the very-high-efficacy, selective 5-HT(1A) receptor agonist F 13640 [(3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-([(5-methyl-pyridin-2-ylmethyl)-amino]-methyl)piperidin-1-yl]-methanone] was recently discovered to constitute a novel central mechanism of broad-spectrum analgesia that, remarkab...

journal_title：European journal of pharmacology

authors： Bruins Slot LA,Koek W,Tarayre JP,Colpaert FC

更新日期：2003-04-18 00:00:00

abstract：:In the present study, the mechanism of relaxant response of nitric oxide precursor, L-arginine, was investigated in goat isolated coronary artery. L-arginine (1 mM) reversed the U-46619 (1 microM)-induced contraction both in endothelium-intact and endothelium-denuded arterial ring preparations. L-arginine analogues, L...

journal_title：European journal of pharmacology

authors： Deka DK,Mishra SK,Raviprakash V

更新日期：2009-05-01 00:00:00

abstract：:Here we investigated the effect of naloxone-precipitated morphine withdrawal on the release of noradrenaline in hippocampus of the anaesthetised rat. Naloxone (1 mg/kg i.p.) injected 3 and 24 h, but not 3 weeks, after eight daily injections of morphine, induced an immediate increase in hippocampal noradrenaline releas...

journal_title：European journal of pharmacology

authors： Done C,Silverstone P,Sharp T

更新日期：1992-05-14 00:00:00

abstract：:This study was undertaken to investigate the interactive effect of histamine and prostaglandin D(2) in nasal allergic symptoms in rats. The intranasal application of histamine at doses lower than 10 mumol/site caused no sneezing or nasal rubbing. In addition, prostaglandin D(2) also showed no significant increase in t...

journal_title：European journal of pharmacology

authors： Rahman A,Inoue T,Ago J,Ishikawa T,Kamei C

更新日期：2007-01-12 00:00:00

abstract：:The function of gamma-aminobutyric acid type A receptors (GABA(A) receptors) is enhanced by various clinically important drugs including benzodiazepines that act on an allosteric site formed at the interface between the alpha and gamma subunits. In contrast to classical benzodiazepines, the novel pyrazolopyrimidine in...

journal_title：European journal of pharmacology

authors： Wegner F,Deuther-Conrad W,Scheunemann M,Brust P,Fischer S,Hiller A,Diekers M,Strecker K,Wohlfarth K,Allgaier C,Steinbach J,Hoepping A

更新日期：2008-02-02 00:00:00

abstract：:To investigate the abnormal function of T and B lymphocytes involved in collagen-induced arthritis in DBA/1 mice and the regulation role of TACI-Ig on T and B lymphocytes, collagen-induced arthritis models were established in DBA/1 mice. Mice were divided randomly into eight groups, including normal, collagen-induced ...

journal_title：European journal of pharmacology

authors： Liu Y,Zhang L,Wu Y,Tong T,Zhao W,Li P,Huang M,Wang W,Fang J,Wei W

更新日期：2011-03-11 00:00:00

abstract：:Clinical evidence indicates an antiarrhythmic effect of sulfonylureas, which might be blunted by their vascular action. We wanted to investigate the effect of glibenclamide and the new sulfonylthiourea compound 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]-sulfonyl]-3 -me thylthiourea (HMR1883) on cardiac ele...

journal_title：European journal of pharmacology

authors： Dhein S,Pejman P,Krüsemann K

更新日期：2000-06-16 00:00:00