Homologous vs. heterologous desensitization of the adenylate cyclase system in heart cells.

Abstract:

:Exposure of cultured heart muscle cells to noradrenaline led to a decrease in the effects of isoproterenol and prostaglandin E1 on cAMP formation and contraction velocity. However, heterologous desensitization, as measured by prostaglandin E1 stimulation, only occurred at higher noradrenaline concentrations than homologous desensitization (isoproterenol stimulation). As the defects of the adenylate cyclase system in heart failure are attributed to noradrenaline-induced desensitization, it is concluded from the results that, in comparison to the subsensitivity to beta-adrenoceptor agonists in failing human hearts, a decrease in the responsiveness to other receptor-dependent adenylate cyclase stimulators should also occur but only at higher degrees of heart failure.

journal_name

Eur J Pharmacol

authors

Reithmann C,Werdan K

doi

10.1016/0014-2999(88)90370-6

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

99-104

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(88)90370-6

journal_volume

154

pub_type

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