Abstract:
:We investigated the inhibitory effects of 1 mM of the inorganic cations, La3+, Cd2+, Mn2+, Ni2+ and Co2+ on contractions induced by K+ (100 mM) and 5-hydroxytryptamine (5-HT, 10(-5) M) in the isolated rat jugular vein and on contractions induced by K+ (100 mM), 5-HT (10(-5] and noradrenaline (NA, 10(-5) M) in the rat aorta. In the venous preparation, both K(+)- and 5-HT-induced Ca2+ influx could be suppressed completely by all cations studied. In the aorta, the K(+)-induced Ca2+ influx was antagonized completely only by Cd2+. The other cations were less effective and Mn2+ was completely ineffective. Similarly to that in the venous preparation, the 5-HT-induced Ca2+ influx in the aorta was abolished by all the cations. A similar picture was found for the NA-induced Ca2+ influx with the exception of Mn2+, which antagonized the NA-induced contractions only slightly. Although organic calcium entry blockers (CEBs) (nifedipine, diltiazem, flunarizine and gallopamil) inhibited NA-induced contractions to the same extent as did Mn2+, a combination of organic CEBs and Mn2+ abolished the NA-induced Ca2+ influx completely. Apparently, organic CEBs and Mn2+ block different components of the NA-induced Ca2+ influx pathway.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Gouw MA,Wilffert B,Van Zwieten PAdoi
10.1016/0014-2999(90)90634-isubject
Has Abstractpub_date
1990-08-28 00:00:00pages
147-55issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(90)90634-Ijournal_volume
185pub_type
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