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RO 16-6028, a benzodiazepine receptor partial agonist, does not exhibit anticonvulsant tolerance in mice.

Abstract：

:The development of anticonvulsant tolerance with RO 16-6028, a benzodiazepine receptor partial agonist, was assessed in mice using an i.v. infusion of pentylenetetrazol as the convulsive stimulus. In contrast to other benzodiazepines tested previously in this seizure model the anticonvulsant protection afforded by RO 16-6028 did not change significantly during 10 days treatment (2 mg/kg b.i.d.). This result supports the hypothesis that partial agonists at the benzodiazepine receptor may induce less tolerance and/or dependence than full agonists.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Haigh JR,Feely M

doi

10.1016/0014-2999(88)90788-1

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

283-5

issue

2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(88)90788-1

journal_volume

147

pub_type

杂志文章

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