Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen.

abstract：:The systemic administration of polyamines (s.c.) produced a dose-dependent motor depression. With high doses the depressant effect was long-lasting and the animals showed signs of toxicity. ED50 values for spermine, spermidine and putrescine were 38, 90 and 251 mg/kg respectively. The motor depression induced by the s...

journal_title：European journal of pharmacology

authors： Giménez-Llort L,Ferré S,De Vera N,Martínez E

更新日期：1996-12-30 00:00:00

abstract：:Acoustic communication in male Chorthippus biguttulus is a suitable behavioral model to explore the physiological effects and underlying molecular mechanisms of identified neuropeptides. Proctolin plays a modulatory role in a neuronal circuit controlling sexual behavior in these insects. Activation of proctolin recept...

journal_title：European journal of pharmacology

authors： Vezenkov SR,Danalev DL

更新日期：2009-10-01 00:00:00

abstract：:Oxidative stress is usually considered as an important factor to the pathogenesis of various diseases. Peroxynitrite (ONOO(-)) and hypochlorite (OCl(-)) are formed in immune cells as a part of the innate host defense system, but excessive reactive oxygen species generation can cause progressive inflammation and tissue...

journal_title：European journal of pharmacology

authors： Ren X,Ding Y,Lu N

更新日期：2016-03-15 00:00:00

abstract：:Local administration of amitriptyline into the rat hindpaw produces peripheral antinociception; this is reduced by adenosine receptor antagonists and appears to involve endogenous adenosine. The present study used peripheral microdialysis: (a) to determine whether amitriptyline could enhance extracellular tissue level...

journal_title：European journal of pharmacology

authors： Sawynok J,Reid AR,Liu XJ,Parkinson FE

更新日期：2005-08-22 00:00:00

abstract：:Cannabinoid drugs differ in their rank order of potency to produce analgesia versus other central nervous system effects. We propose that these differences are due to unique agonist-bound cannabinoid CB1 receptor conformations that exhibit different affinities for individual subsets of intracellular signal transductio...

journal_title：European journal of pharmacology

authors： Georgieva T,Devanathan S,Stropova D,Park CK,Salamon Z,Tollin G,Hruby VJ,Roeske WR,Yamamura HI,Varga E

更新日期：2008-02-26 00:00:00

abstract：:In the present study the antagonism of fentanyl pharmacodynamics was studied in the mouse and the receptor populations mediating the analgesic and lethal effects of fentanyl were examined. Both 1 and 8 days following implantation (s.c.) of a 15 mg naltrexone pellet there was a significant shift to the right of the fen...

journal_title：European journal of pharmacology

authors： Jang Y,Yoburn BC

更新日期：1991-05-17 00:00:00

abstract：:Troxypyrrolidinium, a choline uptake inhibitor, reduced but failed to abolish responses of the rat urinary bladder to electrical stimulation at 1-100 Hz although it reduced acetylcholine output during stimulation at 10 Hz to a level similar to that of spontaneous release. Inhibition of the response to stimulation was ...

journal_title：European journal of pharmacology

authors： Choo LK,Mitchelson F

更新日期：1980-02-08 00:00:00

abstract：:The effect of colchicine on jejunal adenylate cyclase activity, prostaglandin E2 (PGE2) and cAMP contents, the enzyme and mediators involved in intestinal fluid secretion was tested in rats. Four h after the intraperitoneal injection of colchicine (0.5 mg/100 g body wt.) mucosal PGE2 content, adenylate cyclase activit...

journal_title：European journal of pharmacology

authors： Rachmilewitz D,Karmeli F

更新日期：1980-10-17 00:00:00

abstract：:The alpha 1-adrenoceptors present in the liver of rhesus monkeys was characterized using [3H]prazosin. This radioligand binds to monkey liver membranes with high affinity (KD 0.33 nM) to a moderately abundant number of sites (97 fmol/mg of protein). These sites were characterized pharmacologically, by binding competit...

journal_title：European journal of pharmacology

authors： García-Sáinz JA,Romero-Avila MT,González-Espinosa C

更新日期：1996-09-12 00:00:00

abstract：:Airway responsiveness to histamine, substance P, methacholine and bilateral electrical vagal stimulation was assessed in capsaicin-treated and control guinea pigs. In animals treated with capsaicin (50 mg/kg s.c.) 7 days before experiments, airway responsiveness to histamine, substance P and vagal stimulation was sign...

journal_title：European journal of pharmacology

authors： Biggs DF,Ladenius RC

更新日期：1990-01-03 00:00:00

abstract：:We have investigated the effects of substituting extracellular Na+ by choline or K+ on responses of quin2- and fura-2-loaded human platelets to thrombin and platelet-activating factor (PAF). Na+ substitution by choline did not affect the extent of the rise in [Ca2+]i evoked by either agonist. The response to thrombin,...

journal_title：European journal of pharmacology

authors： Sage SO,Rink TJ

更新日期：1986-08-22 00:00:00

abstract：:The purpose of the current study was to assess neuropeptidergic alterations during a phase of the drug addiction cycle associated with drug craving as compared to a time period when the drug had been recently self-administered. Male Wistar rats were allowed to self-administer cocaine, heroin or saline for 6 h for 5 co...

journal_title：European journal of pharmacology

authors： Cappendijk SL,Hurd YL,Nylander I,van Ree JM,Terenius L

更新日期：1999-01-22 00:00:00

abstract：:Lung fibrosis is a common side effect of the chemotherapeutic agent, bleomycin. Current evidence suggests that reactive oxygen species may play a key role in the development of lung fibrosis. The present study examined the effect of mesna on bleomycin-induced lung fibrosis in rats. Animals were divided into three grou...

journal_title：European journal of pharmacology

authors： El-Medany A,Hagar HH,Moursi M,At Muhammed R,El-Rakhawy FI,El-Medany G

更新日期：2005-02-10 00:00:00

abstract：:UP 269-6, 5-methyl-7-propyl-8(-)[2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]-1,2,4-triazolo]1,5-c]pyrimidin-2(3H)-one is a novel nonpeptide angiotensin II receptor antagonist. In vivo studies were performed to evaluate UP 269-6 for its angiotensin II antagonistic action. In pithed rats, i.v. administration of UP 269-6...

journal_title：European journal of pharmacology

authors： Cazes M,Provost D,Versigny A,Cloarec A

更新日期：1995-09-15 00:00:00

abstract：:The effects of morphine (0.1 mg/kg) and 5-HTP (2 mg/kg) on colonic motility were investigated in dogs fasted for 15-22 h and fitted with two strain gauge transducers on the transverse colon at 8 and 12 cm from the ileo-colonic junction. The effects were compared to those obtained after previous intravenous (i.v.) (0.2...

journal_title：European journal of pharmacology

authors： Bueno L,Fioramonti J

更新日期：1982-08-27 00:00:00

abstract：:Statins have recently been shown to produce anti-cardiac hypertrophic effects via the regulation of small GTPases. However, the effects of statins on G protein-mediated cardiac hypertrophy, which is the main pathway of cardiac hypertrophy, have not yet been studied. We sought to evaluate whether statin treatment direc...

journal_title：European journal of pharmacology

authors： Choi EY,Chang W,Lim S,Song BW,Cha MJ,Kim HJ,Choi E,Jang Y,Chung N,Hwang KC

更新日期：2010-02-10 00:00:00

abstract：:Partial bladder outlet obstruction of the pig is considered as a valuable preclinical model for evaluating the profile of compounds for the treatment of bladder overactivity. In this study, we characterized the pharmacological properties of isolated bladder smooth muscle from pigs following partial outlet obstruction ...

journal_title：European journal of pharmacology

authors： Milicic I,Buckner SA,Daza A,Coghlan M,Fey TA,Brune ME,Gopalakrishnan M

更新日期：2006-02-17 00:00:00

abstract：:A large body of evidence has shown that the Corticotropin Releasing Factor (CRF) system, which plays a key role in stress modulation, is deeply involved in relapse to alcohol seeking induced by exposure to stressful events such as foot shock or yohimbine injections. Exposure to environmental cues is also known to be a...

journal_title：European journal of pharmacology

authors： Galesi FL,Ayanwuyi LO,Mijares MG,Cippitelli A,Cannella N,Ciccocioppo R,Ubaldi M

更新日期：2016-10-05 00:00:00

abstract：:The hypotensive activity of a series of calcium entry blockers and various other vasodilators was quantified in pentobarbitone-anesthetized rats. Hypotensive activity was correlated linearly with the potency of these vasoactive agents to depress alpha 2-adrenoceptor-induced pressor responses in pithed rats. However, v...

journal_title：European journal of pharmacology

authors： Van Meel JC,Timmermans PB,Van Zwieten PA

更新日期：1983-08-19 00:00:00

abstract：:The effects of clonidine and dl-propranolol on negative pressure breathing-induced diuresis in chloralose-anaesthetized dog were studied. Clonidine (10 microgram/kg i.v.) suppressed the diuretic response, whereas dl-propranolol (1 mg/kg i.v.) was inactive. ...

journal_title：European journal of pharmacology

authors： Montastruc P,Montastruc JL,Tran LD

更新日期：1981-07-10 00:00:00

abstract：:High stereoselectivity was observed for the enantiomers of trihexyphenidyl and trihexyphenidyl methiodide at muscarinic M1-receptors in field-stimulated rabbit vas deferens and at M2 alpha- and M2 beta-receptors in guinea-pig atrium and ileum, respectively. Considerably higher affinities (up to 1700-fold) were found f...

journal_title：European journal of pharmacology

authors： Lambrecht G,Feifel R,Moser U,Aasen AJ,Waelbroeck M,Christophe J,Mutschler E

更新日期：1988-10-11 00:00:00

abstract：:The involvement of delta opioid receptors in supraspinal analgesia was investigated. With this aim, opioids that produced analgesia in the tail immersion test were administered i.c.v. to mice a few minutes before the irreversible antagonist, beta-funaltrexamine (beta-FNA). Protection of the respective analgesic effect...

journal_title：European journal of pharmacology

authors： Sánchez-Blázquez P,Garzón J

更新日期：1989-01-02 00:00:00

abstract：:The extracts of Phellodendron amurense (P. amurense) have been shown to contain many active ingredients e.g. flavone glycosides and to exert a wide range of physiological activities including anti-tumor activity. However, the effects of phellamurin (Phe), a plant flavonone glycoside from the leaves of P. amurense, on ...

journal_title：European journal of pharmacology

authors： Zhang H,Jiang H,Zhang H,Liu J,Hu X,Chen L

更新日期：2019-09-05 00:00:00

abstract：:Emodin, an anthraquinone derivative isolated from root and rhizome of Rheum palmatum, has been reported to have promising anti-diabetic activity. The present study was to explore the possible mechanism of emodin to ameliorate insulin resistance. Insulin resistance was induced by feeding a high fat diet to Sprague-Dawl...

journal_title：European journal of pharmacology

authors： Cao Y,Chang S,Dong J,Zhu S,Zheng X,Li J,Long R,Zhou Y,Cui J,Zhang Y

更新日期：2016-06-05 00:00:00

abstract：:The present study was undertaken to investigate the effects of intracavernosal injections of adrenomedullin, a novel hypotensive peptide, on penile erection in anesthetized cats. Responses to adrenomedullin were compared to those elicited by intracavernosal injection of the control triple-drug combination (1.65 mg pap...

journal_title：European journal of pharmacology

authors： Champion HC,Wang R,Shenassa BB,Murphy WA,Coy DH,Hellstrom WJ,Kadowitz PJ

更新日期：1997-01-14 00:00:00

abstract：:Leukocytes can generate a substance that, when added to some partially purified human kininogen, is capable of forming kinins. The addition of endotoxin or polystyrene latex particles to the incubated leukocytes doubled the amount of kinin generated. Certain preparations of kininogen, however, failed to allow kinin fo...

journal_title：European journal of pharmacology

authors： Miller RL,Webster ME,Melmon KL

更新日期：1975-08-01 00:00:00

abstract：:We compared the cumulative dose-response relations of verapamil (0.1, 0.2 and 0.4 mg kg(-1)) in different R/S enantiomer ratios (100/0, 90/10, 80/20, 50/50 and 20/80) on the electrophysiological and hemodynamic characteristics of the heart using the conscious dogs. A reduction of mean arterial pressure occurred with 2...

journal_title：European journal of pharmacology

authors： Takahata O,Krolikowski JG,McCallum JB,Lathrop DA,Bosnjak ZJ

更新日期：1998-08-21 00:00:00

abstract：:The suppressing effect of acamprosate (calcium-acetyl homotaurinate) on alcohol drinking is well established; however, little is known about its effects upon the alcohol-induced withdrawal syndrome. Male Wistar rats received as a sole drinking fluid a 20% (v/v) alcohol solution for one week. Animals consumed on averag...

journal_title：European journal of pharmacology

authors： Spanagel R,Putzke J,Stefferl A,Schöbitz B,Zieglgänsberger W

更新日期：1996-06-03 00:00:00

abstract：:The effects of cyclic nucleotide analogs and related agents on the Ca2+ dependent action potentials of cultured rat aortic smooth muscle cells (reaggregates) were examined. The action potentials were elicited by electrical stimulation in the presence of tetraethylammonium (TEA, 5-15 mM). Superfusion of the aortic cell...

journal_title：European journal of pharmacology

authors： Ousterhout JM,Sperelakis N

更新日期：1987-11-24 00:00:00

abstract：:The present study aims to investigate whether azithromycin reverses P-glycoprotein-dependent anticancer drug resistance in vitro and modifies the hepatobiliary excretion of doxorubicin, a substrate for P-glycoprotein in vivo. Azithromycin increased dose-dependently the intracellular accumulation of doxorubicin in adri...

journal_title：European journal of pharmacology

authors： Asakura E,Nakayama H,Sugie M,Zhao YL,Nadai M,Kitaichi K,Shimizu A,Miyoshi M,Takagi K,Takagi K,Hasegawa T

更新日期：2004-01-26 00:00:00