Abstract:
:A large body of evidence has shown that the Corticotropin Releasing Factor (CRF) system, which plays a key role in stress modulation, is deeply involved in relapse to alcohol seeking induced by exposure to stressful events such as foot shock or yohimbine injections. Exposure to environmental cues is also known to be a trigger for alcohol relapse, nevertheless, the relationship between the relapse evoked by the cue-induced model and the CRF stress systems remains unclear. The purpose of this study was to evaluate, in male Wistar rats, the involvement of the CRF system and Hypothalamic-Pituitary-Adrenal (HPA) axis in relapse induced by environmental cues. Antalarmin, a selective CRF1 receptor antagonist, Metyrapone, a corticosterone (CORT) synthesis inhibitor and CORT were evaluated for their effects on the reinstatement test in a cue-induced relapse model. Antalarmin (20mg/kg) blocked relapse to alcohol seeking induced by environmental cues. Metyrapone (50 and 100mg/kg) also blocked relapse in Wistar rats but only at the highest dose (100mg/kg). Corticosterone had no effect on relapse at the doses tested. The results obtained from this study suggest that the CRF stress system and the HPA axis are involved in cue-induced alcohol relapse.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Galesi FL,Ayanwuyi LO,Mijares MG,Cippitelli A,Cannella N,Ciccocioppo R,Ubaldi Mdoi
10.1016/j.ejphar.2016.06.020subject
Has Abstractpub_date
2016-10-05 00:00:00pages
84-89eissn
0014-2999issn
1879-0712pii
S0014-2999(16)30379-Xjournal_volume
788pub_type
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