Alterations of beta-receptor-adenylyl cyclase coupling by long-term ATP depletion in cultured rat cardiomyocytes.

abstract：:A cDNA clone which encodes a putative kainate receptor was prepared with the polymerase chain reaction; from this, 'antisense' RNA fragments were produced and used to evaluate the distribution of mRNA for the kainate-receptor in rat brain with in situ hybridization techniques. The data demonstrate marked regional diff...

journal_title：European journal of pharmacology

authors： Gall C,Sumikawa K,Lynch G

更新日期：1990-09-18 00:00:00

abstract：:The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as well as intestinal Mrp2 expression, was analyzed in CCl(4)-induced acute hepatic failure rats with hyperbilirubinemia. The plasma level of bilirubin glucuronides, endogenous Mrp2-substrates, was 26 microM at 24 h after CCl(...

journal_title：European journal of pharmacology

authors： Yokooji T,Murakami T,Yumoto R,Nagai J,Takano M

更新日期：2006-09-28 00:00:00

abstract：:Trans-dehydrocrotonin has antiulcerogenic and antitumor activities. A complex of beta-cyclodextrin with dehydrocrotonin was developed to improve the delivery of dehydrocrotonin. Complex in solid state was evaluated using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TG...

journal_title：European journal of pharmacology

authors： Corrêa DH,Melo PS,de Carvalho CA,de Azevedo MB,Durán N,Haun M

更新日期：2005-03-07 00:00:00

abstract：:Many studies have shown that anti-inflammatory agents are effective in the treatment of endometriosis. β-Caryophyllene exerted a potent anti-inflammatory effect in vivo. However, its effect on endometriosis has not been investigated. This study aims at investigating the effect of β-caryophyllene on endometriosis and o...

journal_title：European journal of pharmacology

authors： Abbas MA,Taha MO,Zihlif MA,Disi AM

更新日期：2013-02-28 00:00:00

abstract：:Alzheimer's disease is the most frequent cause of dementia. Family and twin studies have suggested that genetic factors play a role in Alzheimer's disease development. Some Alzheimer's disease cases show an autosomal dominant inheritance pattern and thus allow the discovery of major disease genes. However, most Alzhei...

journal_title：European journal of pharmacology

authors： Richard F,Amouyel P

更新日期：2001-01-19 00:00:00

abstract：:The effect of furosemide on carbohydrate metabolism was studied in ob/ob mice. Intraperitoneal injection of a single dose of furosemide (200 mg/kg body weight) into fasted mice resulted in acute hyperglycaemia and two days after such a single dose, the mice showed fasting hyperglycaemia and glucose intolerance. Pancre...

journal_title：European journal of pharmacology

authors： Sandström PE,Sehlin J

更新日期：1988-03-15 00:00:00

abstract：:In strips of pig coronary arteries incubated in oxygenated Krebs-bicarbonate solution at 37 degrees C, dotarizine blocked the phasic contractions evoked by 5-HT (0.5 microM) or K+ depolarization (35 mM K+) with an IC50 of 0.22 and 3.7 microM, respectively. Flunarizine inhibited both types of contractions with IC50 val...

journal_title：European journal of pharmacology

authors： Montiel C,Herrero CJ,García-Palomero E,Renart J,García AG,Lomax RB

更新日期：1997-08-06 00:00:00

abstract：:Using microscopic fluorometry and fura-2-loaded cultured bovine aortic endothelial cells, we determined the effects of captopril, an angiotensin converting enzyme (ACE) inhibitor, on bradykinin-induced Ca2+ transients in endothelial cells. In the presence of extracellular Ca2+, 10(-9) M bradykinin induced an early ris...

journal_title：European journal of pharmacology

authors： Hirano K,Hirano M,Kanaide H

更新日期：1993-01-15 00:00:00

abstract：:The functional role of P2X7 receptor (P2X7R) inhibition in cancer-induced bone pain has been highly contradictory. Whereas knockout studies have suggested pro-nociceptive effects, pharmacological studies suggest anti-nociceptive or no effect. The discrepancy is likely linked to the highly polymorphic nature of the P2X...

journal_title：European journal of pharmacology

authors： Falk S,Appel CK,Bennedbæk HB,Al-Dihaissy T,Unger A,Dinkel K,Heegaard AM

更新日期：2019-02-15 00:00:00

abstract：:This study examined the mechanism of action of neurotensin on intraluminal pressure in rat proximal colon. The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca(2+)-free solution, and was antagonized by nifedipine (1-5-10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dime...

journal_title：European journal of pharmacology

authors： Mulè F,Serio R

更新日期：1997-01-29 00:00:00

abstract：:There is a large body of evidence to suggest that the sympathetic nervous system plays a critical role in the development of hypertension and vascular medial hypertrophy in the spontaneously hypertensive rat (SHR). The synthesis of a water soluble, specific alpha 1-adrenoceptor antagonist (terazosin) has permitted an ...

journal_title：European journal of pharmacology

authors： Jonsson JR,Head RJ,Frewin DB

更新日期：1992-02-11 00:00:00

abstract：:Low doses of BHT 920, LY 171555 and (+)3PPP, three dopamine agonists selective for D-2 receptors, induced yawning in rats. This effect was reduced by the selective D-1 antagonist SCH 23390 but the antagonism did not exceed a 50% reduction from the control values. In contrast, the selective D-2 antagonist (-)sulpiride ...

journal_title：European journal of pharmacology

authors： Longoni R,Spina L,Di Chiara G

更新日期：1987-02-10 00:00:00

abstract：:Bitter taste receptors (Tas2rs) initiate a bitter taste signaling involving the activation of taste-specific G protein gustducin and phosphodiesterases (PDEs); it leads to the decrease of cytosolic level of cyclic adenosine monophosphate (cAMP) in taste cells. Recent studies have identified the expression of Tas2rs in...

journal_title：European journal of pharmacology

authors： Liu M,Qian W,Subramaniyam S,Liu S,Xin W

更新日期：2020-04-05 00:00:00

abstract：:Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension. Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magn...

journal_title：European journal of pharmacology

authors： Versteeg CA,Cransberg K,De Jong W,Bohus B

更新日期：1983-10-14 00:00:00

abstract：:The present study concerns previously unreported effects of menthol, a cyclic terpene alcohol produced by the peppermint herb, on anion transporters in polarized human airway Calu-3 epithelia. Application of menthol (0.01-1mM) attenuated transepithelial anion transport, estimated as short-circuit currents (I(SC)), aft...

journal_title：European journal of pharmacology

authors： Morise M,Ito Y,Matsuno T,Hibino Y,Mizutani T,Ito S,Hashimoto N,Kondo M,Imaizumi K,Hasegawa Y

更新日期：2010-06-10 00:00:00

abstract：:Contractile responses to endothelin, 5-hydroxytryptamine (5-HT), noradrenaline and potassium were obtained on isolated preparations of pulmonary artery from rats made pulmonary hypertensive by an injection of monocrotaline (105 mg/kg s.c.) 4 weeks previously. When compared with data obtained in control rats, the poten...

journal_title：European journal of pharmacology

authors： Wanstall JC,O'Donnell SR

更新日期：1990-02-06 00:00:00

abstract：:The effects of intracellular and extracellular application of bretylium tosylate on outward potassium current and fast inward Na+ current have been studied in single ventricular cells of chick embryo (18-day-old) using the whole-cell voltage clamp technique. Extracellular superfusion with bretylium (3 x 10(-4) M) decr...

journal_title：European journal of pharmacology

authors： Bkaily G,Payet MD,Benabderrazik M,Sauvé R,Renaud JF,Bacaner M,Sperelakis N

更新日期：1988-07-14 00:00:00

abstract：:Intracellular accumulation of calcium is thought to play an integral role in the progression of ischemic injury and cell death. We infused the calcium entry blocker, nitrendipine (1.5 micrograms/kg per min), into cats in order to investigate the importance of extracellular Ca2+ influx during hemorrhagic shock. Nitrend...

journal_title：European journal of pharmacology

authors： Hock CE,Su JY,Lefer AM

更新日期：1984-01-13 00:00:00

abstract：:Multidrug resistance phenotype in mammalian cells is often correlated with overexpression of P-glycoprotein or Multidrug Resistance-Associated protein (MRP(1)). Both proteins are energy-dependent drug efflux pumps that efficiently reduce the intracellular accumulation and hence the cytotoxicity of many natural cytotox...

journal_title：European journal of pharmacology

authors： Marbeuf-Gueye C,Salerno M,Quidu P,Garnier-Suillerot A

更新日期：2000-03-17 00:00:00

abstract：:Haloperidol increased 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations in the striatum, nucleus accumbens and olfactory tubercle of both drug-naive rats and rats pretreated with haloperidol (10 injections). The increases in metabolite concentrations were greater in all brain regions of the naive rat...

journal_title：European journal of pharmacology

authors： Finlay JM,Jakubovic A,Fu DS,Fibiger HC

更新日期：1987-05-07 00:00:00

abstract：:The effect of apomorphine (ap) was investigated in rats kept in a familiar cage; 0.25-5 mg/kg s.c. produced a short-lasting, abnormal hypermotility consisting mainly of locomotion and sniffing without grooming. Ap was administered to rate pretreated s.c. with various drugs. Ap hypermotility was antagonized by 12 neuro...

journal_title：European journal of pharmacology

authors： Lassen JB

更新日期：1976-04-01 00:00:00

abstract：:Activated factor X (FXa) is an important player in the coagulation cascade responsible for thrombin generation, which is activated during atrial fibrillation. Increasing evidence suggests that FXa influences cell signalling in various cell types by activating protease-activated receptors (PARs). It is so far not known...

journal_title：European journal of pharmacology

authors： Bukowska A,Zacharias I,Weinert S,Skopp K,Hartmann C,Huth C,Goette A

更新日期：2013-10-15 00:00:00

abstract：:Pharmacological strategies aimed at co-activating peroxisome proliferator-activated receptor-gamma (PPAR-γ)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway have shown promising results in alleviating myocardial injury. The aim of the study was to evaluate the role of chrysin, a PPAR-γ agonist, in ischemia-r...

journal_title：European journal of pharmacology

authors： Rani N,Arya DS

更新日期：2020-09-15 00:00:00

abstract：:The tripeptides SD-34 and SD-25 induced atropine-, guanethidine-, antihistaminics-resistant but naloxone-sensitive contractions of isolated rat distal colon. They appeared to act on an opioid receptor, probably of the mu subtype, distinct from those for methionine enkephalin and morphine, because the pA2 values of nal...

journal_title：European journal of pharmacology

authors： Moritoki H,Takei M,Kotani M,Kiso Y,Ishida Y,Endoh K

更新日期：1984-04-13 00:00:00

abstract：:We have confirmed our earlier finding that most red wines are able to bring about 5-hydroxytryptamine (5-HT, serotonin) release from platelets in vitro. Platelets from individual subjects manifested varying degrees of releasing ability but responded to different wines with a similar rank ordering. There was a high cor...

journal_title：European journal of pharmacology

authors： Pattichis K,Louca LL,Jarman J,Sandler M,Glover V

更新日期：1995-01-13 00:00:00

abstract：:SB203580 is the prototypical p38 MAPK inhibitor; however it cannot be used clinically due to liver toxicity. We developed a structural analogue of SB203580 - ML3403 - with equal in vitro and ex vivo p38alpha MAPK inhibition as SB203580, but with reduced activity towards liver cytochrome P450 enzymes. In addition, we d...

journal_title：European journal of pharmacology

authors： Munoz L,Ramsay EE,Manetsch M,Ge Q,Peifer C,Laufer S,Ammit AJ

更新日期：2010-06-10 00:00:00

abstract：:The effect of peripheral and intrathecal administration of the bradykinin B2 receptor antagonist HOE140 and the non-steroidal anti-inflammatory drug indomethacin were studied on the response of dorsal horn nociceptive neurones to formalin in the anaesthetized rat. Peripheral pretreatment with HOE140 reduced both phase...

journal_title：European journal of pharmacology

authors： Chapman V,Dickenson AH

更新日期：1992-09-04 00:00:00

abstract：:Activation of cannabinoid receptor 1 (CB1) inhibits synaptic transmission in hippocampal neurons. The goal of this study was to evaluate the ability of benchmark and emerging synthetic cannabinoids to suppress neuronal activity in vitro using two complementary techniques, Ca(2+) spiking and multi-electrode arrays (MEA...

journal_title：European journal of pharmacology

authors： Tauskela JS,Comas T,Hewitt M,Aylsworth A,Zhao X,Martina M,Costain WJ

更新日期：2016-09-05 00:00:00

abstract：:In previous studies using Fos expression as a marker of neuronal activation, we showed that nitrous oxide (N(2)O) activates bulbospinal noradrenergic neurons in rats and that destruction of these neuronal pathways leads to loss of N(2)O antinociceptive action. Based on previous rat studies it has been proposed that th...

journal_title：European journal of pharmacology

authors： Kingery WS,Sawamura S,Agashe GS,Davies MF,Clark JD,Zimmer A

更新日期：2001-09-07 00:00:00

abstract：:This study was designed to determine how the contractility of rat detrusor smooth muscle strips changes in the presence of low concentrations of hydrogen peroxide (H(2)O(2)). The strips were dissected from the base of Sprague-Dawley rat bladders and their contractile responses to a cumulative increase in H(2)O(2) conc...

journal_title：European journal of pharmacology

authors： Han JH,Lee MY,Lee SY,Chang IH,Kim HJ,Kim W,Myung SC

更新日期：2010-07-25 00:00:00