Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.

abstract：:Dysfunction of the innate immune system has been reported to cause intestinal inflammation. Vitamin D3 is known to be an important immune system regulator and exerts anti-inflammatory effects. We investigated in vitro effects of vitamin D3 and its derivatives on the innate immune system in HT-29 cells, a line of human...

journal_title：European journal of pharmacology

authors： Hidaka M,Wakabayashi I,Takeda Y,Fukuzawa K

更新日期：2013-12-05 00:00:00

abstract：:The renal vascular effects of dopaminomimetics were studied in the isolated perfused rat kidney after pretreatment with 10(-5) M phenoxybenzamine and 10(-5) M sotalol and after contraction of the vascular bed with prostaglandin F2 alpha (10(-7) to 3 x 10(-6) M). Under these conditions, our criterion for vascular dopam...

journal_title：European journal of pharmacology

authors： Schmidt M,Imbs JL,Giesen EM,Schwartz J

更新日期：1982-10-15 00:00:00

abstract：:Induction of lower lip retraction after local infusion of the selective 5-HT1A receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal and median raphe nuclei was measured. Infusion of 8-OH-DPAT (2.5, 5 and 10 micrograms/rat) into the median raphe nucleus caused an immediate and dose-de...

journal_title：European journal of pharmacology

authors： Berendsen HH,Bourgondien FG,Broekkamp CL

更新日期：1994-10-03 00:00:00

abstract：:The physiological role of NPFF/FMRFa family of peptides appears to be complex and exact mechanism of action of these peptides is not yet completely understood. In same line of scrutiny, another analog of YGGFMKKKFMRFamide (YFa), a chimeric peptide of met-enkephalin and FMRFamide, was rationally designed and synthesize...

journal_title：European journal of pharmacology

authors： Vats ID,Chaudhary S,Sharma A,Nath M,Pasha S

更新日期：2010-07-25 00:00:00

abstract：:To investigate the role of ATP-sensitive K+(KATP) channels on pacemaker activity in interstitial cells of Cajal (ICC), whole-cell patch clamping, RT-PCR, and intracellular Ca2+([Ca2+]i) imaging were performed in cultured colonic ICC. Pinacidil (a K+ channel opener) hyperpolarized the membrane and inhibited the generat...

journal_title：European journal of pharmacology

authors： Na JS,Hong C,Kim MW,Park CG,Kang HG,Wu MJ,Jiao HY,Choi S,Jun JY

更新日期：2017-08-15 00:00:00

abstract：:59Fe was incorporated in vivo into intestinal sacs prepared in iron deficient rats and 59Fe counts were detected in blood, spleen, liver, femur and intestine. The i.v. injection of isoproterenol (i.v. 2 micrograms/rat) or N',O'-dibutyryladenosine 3',5'-cyclic monophosphate (10 microM/100 g b.w.) enhanced significantly...

journal_title：European journal of pharmacology

authors： Gutnisky A,Borda ES,Gimeno AL

更新日期：1984-05-04 00:00:00

abstract：:The 5-lipoxygenase inhibitors WY-50,295 tromethamine, A-64,077, L-663,536 and ICI-207,968 were compared in a reverse passive Arthus reaction-induced pleurisy model of eicosanoid biosynthesis in the rat. When a 1 h pretreatment schedule was employed, all four inhibitors equivalently blocked leukotriene B4 (LTB4) produc...

journal_title：European journal of pharmacology

authors： Berkenkopf JW,Weichman BM

更新日期：1991-01-25 00:00:00

abstract：:The effect of Ca2+ on the oxytocin-induced, sustained contraction of rat uterine muscle in Ca-free medium after prolonged incubation with 3 mM EGTA (Ca-free contraction) was investigated. A micromolar concentration of Ca2+ caused phasic contraction followed by relaxation while a submicromolar concentration caused rela...

journal_title：European journal of pharmacology

authors： Matsuo K,Uchida MK

更新日期：1987-08-21 00:00:00

abstract：:Nicotine acts as an agonist of nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors play a role in the modulation of neurotransmitter release in both the central and the peripheral nervous system. Moderate reactive oxygen species levels modulate the regulation of physiological functions e.g. neurotrans...

journal_title：European journal of pharmacology

authors： Ozger Ilhan S,Sarioglu Y,Vural IM,Dileköz E,Oztürk GS,Ercan ZS

更新日期：2008-06-10 00:00:00

abstract：:AQA39 is a new cardioactive agent with, at low dosages, a minute positive inotropic action on ventricular myocardial tissue probably mediated through the calcium sequestering membraneous systems. At higher concentrations AQA39 depressed myocardial performance probably due to inhibition of the slow calcium channels. ...

journal_title：European journal of pharmacology

authors： Sys SU,De Clerck NM,Brutsaert DL

更新日期：1984-08-03 00:00:00

abstract：:We recently reported that wood smoke inhalation initially (within 5 min) causes airway injury and subsequently produces both airway and parenchymal injury after a delay (within 2 h). In this study, we investigated the mediator mechanisms of this delayed smoke-induced lung injury in 126 anesthetized and artificially ve...

journal_title：European journal of pharmacology

authors： Lin YS,Ho CY,Tang GJ,Kou YR

更新日期：2001-08-10 00:00:00

abstract：:We examined which subtypes of alpha 1-adrenoceptors are expressed in rat vena cava by using both functional and [3H]prazosin binding experiments. Pretreatment with chloroethylclonidine inactivated about 80% of the specific [3H]prazosin binding sites and reduced the maximal noradrenaline-induced contraction to the same...

journal_title：European journal of pharmacology

authors： Sayet I,Neuilly G,Rakotoarisoa L,Mironneau J,Mironneau C

更新日期：1993-08-15 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is a key enzyme that catalyzes the biosynthesis of prostaglandins from arachidonic acid and plays a critical role in some pathologies including inflammation, neurodegenerative diseases and cancer. Cryptotanshinone is a major constituent of tanshinones, which are extracted from the medicinal he...

journal_title：European journal of pharmacology

authors： Jin DZ,Yin LL,Ji XQ,Zhu XZ

更新日期：2006-11-07 00:00:00

abstract：:The effects of clozapine on dopamine neurons projecting to the medial-prefrontal cortex, nuclei accumbens and caudatus were compared. Clozapine (1.25 mg/kg i.v.) maximally stimulated the firing rate and burst activity of dopamine neurons projecting to the medialprefrontal cortex. Much higher doses (5 and 10 mg/kg i.v....

journal_title：European journal of pharmacology

authors： Melis M,Diana M,Gessa GL

更新日期：1999-02-05 00:00:00

abstract：:The effect of acute exposure to micromolar concentrations of kainic acid was studied in rat cerebellar astroglial cultures consisting of two antigenically and functionally distinct subpopulations of astrocytes. Kainate (20-100 microM) released [3H]GABA preaccumulated by A2B5-positive stellate astrocytes in a concentra...

journal_title：European journal of pharmacology

authors： Gallo V,Suergiu R,Levi G

更新日期：1986-12-16 00:00:00

abstract：:Mutant alph1 subunits of the GABA(A) receptor were coexpressed in combination with the wild-type beta2 and gamma2 subunits in human embryonic kidney (HEK) 293 cells. The binding properties of various benzodiazepine site ligands were determined by displacement of ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5...

journal_title：European journal of pharmacology

authors： Schaerer MT,Buhr A,Baur R,Sigel E

更新日期：1998-08-07 00:00:00

abstract：:Subplantar injection of 0.10 micrograms of serotonin in the rat resulted in a brief period (0-20 min) of increased pain sensitivity to an applied force (hyperalgesia) which preceded a longer period (40-120 min) of decreased pain sensitivity (hypoalgesia). The magnitude of each of these changes and the duration of the ...

journal_title：European journal of pharmacology

authors： Vinegar R,Truax JF,Selph JL,Johnston PR

更新日期：1989-05-30 00:00:00

abstract：:A brain slice preparation was used to examine the effects of galanin on the spontaneous firing rate of locus coeruleus noradrenergic neurons. Galanin (10(-9)-10(-7) M), added to the bath, inhibited the firing of 14 out of 19 neurons in a concentration-dependent manner. The observed effect was quite variable, ranging f...

journal_title：European journal of pharmacology

authors： Seutin V,Verbanck P,Massotte L,Dresse A

更新日期：1989-05-19 00:00:00

abstract：:We investigated the effects of antithrombin, a plasma inhibitor of coagulation factors, in rats with puromycin aminonucleoside-induced nephrosis, which is an experimental model of human nephrotic syndrome. Antithrombin (50 or 500 IU/kg/i.v.) was administered to rats once a day for 10 days immediately after the injecti...

journal_title：European journal of pharmacology

authors： Yamashita J,Nakajima K,Ohno Y,Kaneshiro Y,Matsuo T,Tanaka H,Kaneko K

更新日期：2008-07-28 00:00:00

abstract：:Using the curve-shift method, we studied the effects of four doses (0.003, 0.03, 0.3 and 3 mg/kg, s.c.) of granisetron (endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1-methyl-1H-indazole-3- carboxamide hydrochloride), a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, on the potentiation of brain stimulatio...

journal_title：European journal of pharmacology

authors： Rompré PP,Injoyan R,Hagan JJ

更新日期：1995-12-20 00:00:00

abstract：:Tanshinone IIA, one of the main active components from Chinese herb Danshen, is widely used to treat cardiovascular diseases including arrhythmia in Asian countries especially in China. However, the mechanisms underlying its anti-arrythmia effects are not clear. In this study we investigate the effects of tanshinone I...

journal_title：European journal of pharmacology

authors： Sun DD,Wang HC,Wang XB,Luo Y,Jin ZX,Li ZC,Li GR,Dong MQ

更新日期：2008-08-20 00:00:00

abstract：:The binding of [3H]N-(1-[2-thienyl]cyclohexyl)piperidine (TCP) to N-methyl-D-aspartate (NMDA) receptor sites in synaptic membranes prepared from the dorsal hippocampus of the ischaemic gerbil, has been studied. Forebrain ischaemia was induced by 10 min bilateral carotid occlusion and receptor binding determined in the...

journal_title：European journal of pharmacology

authors： Leach MJ,Hollox KJ,O'Donnell RA,Miller AA

更新日期：1988-07-26 00:00:00

abstract：:It has been reported that the antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) may result from the modulation of brain monoaminergic systems. However, the mechanisms of FDPI action are not fully understood. The aim of this study was to investigate the contribution of N-methyl-d-aspartate ...

journal_title：European journal of pharmacology

authors： Pesarico AP,Stangherlin EC,Rosa SG,Mantovani AC,Zeni G,Nogueira CW

更新日期：2016-07-05 00:00:00

abstract：:Termination of signalling by G-protein-coupled receptors requires inactivation of the G alpha-subunits of heterotrimeric G-proteins and the re-association of G alpha- and G betagamma-subunits. Inactivation of G alpha-subunits is achieved by the hydrolysis of bound GTP by an intrinsic GTPase activity, which is consider...

journal_title：European journal of pharmacology

authors： Karakoula A,Tovey SC,Brighton PJ,Willars GB

更新日期：2008-06-10 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic parameters of the selective serotonin reuptake inhibitor 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phtalancarbonitril (citalopram) were determined in order to find optimal conditions for augmentation of its effect on extracellular serotonin [5-hydroxytryptamine (5-HT)] through ...

journal_title：European journal of pharmacology

authors： Cremers TI,de Boer P,Liao Y,Bosker FJ,den Boer JA,Westerink BH,Wikström HV

更新日期：2000-05-26 00:00:00

abstract：:The effects of escins Ib and IIb isolated from horse chestnuts on Mg(2+) absorption from the digestive tract and the role of endogenous nitric oxide (NO) were investigated in mice. Test samples were given orally to fasted mice 30, 120, 180, 240 and 300 min before administration of 0.5 M MgSO(4) (10 ml/kg, p.o.). The s...

journal_title：European journal of pharmacology

authors： Li Y,Matsuda H,Wen S,Yamahara J,Yoshikawa M

更新日期：2000-01-17 00:00:00

abstract：:In previous studies using Fos expression as a marker of neuronal activation, we showed that nitrous oxide (N(2)O) activates bulbospinal noradrenergic neurons in rats and that destruction of these neuronal pathways leads to loss of N(2)O antinociceptive action. Based on previous rat studies it has been proposed that th...

journal_title：European journal of pharmacology

authors： Kingery WS,Sawamura S,Agashe GS,Davies MF,Clark JD,Zimmer A

更新日期：2001-09-07 00:00:00

abstract：:The antiparkinsonian agent l-deprenyl is metabolized to l-methamphetamine and l-amphetamine and, at higher doses, can facilitate the release and inhibit the reuptake of dopamine. Since l-deprenyl can affect dopamine release and reuptake it was important to evaluate it for cocaine-like discriminative stimulus effects. ...

journal_title：European journal of pharmacology

authors： Yasar S,Schindler CW,Thorndike EB,Goldberg SR

更新日期：1994-07-11 00:00:00

abstract：:[3H]Indapamide bound to a single class of binding sites in pig renal cortex membranes with a dissociation constant Kd = 35 +/- 13 nM and a binding site density Bmax = 40 +/- 9 pmol/mg of protein. [3H]Indapamide binding was inhibited by the carbonic anhydrase inhibitor, acetazolamide, and by thiazide diuretics with the...

journal_title：European journal of pharmacology

authors： Schaeffer P,Vigne P,Frelin C,Lazdunski M

更新日期：1990-07-17 00:00:00

abstract：:Malignant gliomas are the most common primary brain tumors. Due to both their invasive nature and resistance to multimodal treatments, these tumors have a very high percentage of recurrence leading in most cases to a rapid fatal outcome. Recent data demonstrated that neural stem/progenitor cells possess an inherent ab...

journal_title：European journal of pharmacology

authors： Ginisty A,Oliver L,Arnault P,Vallette F,Benzakour O,Coronas V

更新日期：2019-07-15 00:00:00