当前位置： SCI文献检索 > EUROPEAN JOURNAL OF PHARMACOLOGY期刊下所有文献 > Hydrogen peroxide and antioxidizing enzymes involved in modulation of transient facilitatory effects of nicotine on neurogenic contractile responses in rat gastric fundus.

Hydrogen peroxide and antioxidizing enzymes involved in modulation of transient facilitatory effects of nicotine on neurogenic contractile responses in rat gastric fundus.

Abstract：

:Nicotine acts as an agonist of nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors play a role in the modulation of neurotransmitter release in both the central and the peripheral nervous system. Moderate reactive oxygen species levels modulate the regulation of physiological functions e.g. neurotransmitter release. Previously in rabbit gastric fundus we demonstrated that nicotine transiently increased neurogenic contraction induced by electrical field stimulation (EFS). In this study we aimed to investigate the effects of hydrogen peroxide (H2O2), antioxidizing enzymes catalase and superoxide dismutase (SOD) on nicotine induced increases at cholinergic neurotransmission in rabbit gastric fundus. Although H2O2 did not alter nicotine induced transient neurogenic contractions at concentrations of 10(-6) and 10(-5) M, at high concentration (10(-4) M) H2O2 inhibited nicotine induced increases. Catalase (500 units/ml), enhanced the effect of nicotine but did not alter nicotine induced transient neurogenic contractions at the concentrations of 100 and 250 units/ml. SOD (75,150 and 225 units/ml) did not alter nicotine induced transient neurogenic contractions. In conclusion, at high concentration H2O2 (10(-4) M) inhibited nicotine's transient ability to augment neurogenic contractions and catalase (500 units/ml) enhanced the effect of nicotine.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ozger Ilhan S,Sarioglu Y,Vural IM,Dileköz E,Oztürk GS,Ercan ZS

doi

10.1016/j.ejphar.2008.03.029

subject

Has Abstract

pub_date

2008-06-10 00:00:00

pages

267-72

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(08)00365-8

journal_volume

587

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF PHARMACOLOGY文献大全
  • Ouabain-induced contraction of vascular smooth muscle in spontaneously hypertensive rats and the effect of hydralazine.

    abstract：:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(88)90537-7

    authors： Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

    更新日期：1988-07-14 00:00:00

  • Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.

    abstract：:The anti-cancer effects of dioscin have been widely reported. However, its effect on laryngeal cancer remains unknown. In the present paper, our results showed that dioscin markedly caused cell apoptosis and DNA damage, increased reactive oxygen species (ROS) level, induced S-phase arrest, and inhibited invasion of hu...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.02.009

    authors： Si L,Zheng L,Xu L,Yin L,Han X,Qi Y,Xu Y,Wang C,Peng J

    更新日期：2016-03-05 00:00:00

  • Maternal caffeine intake impairs MK-801-induced hyperlocomotion in young rats.

    abstract：:Here we have investigated the effects of maternal caffeine intake (1 g/l) on MK-801-induced hyperlocomotion in rat pups. Animals submitted to caffeine treatment during the gestational and lactational period were separated in two groups: caffeine-treated group (up to 21 days old) and washout group (caffeine treatment u...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2005.01.001

    authors： da Silva RS,Hoffman A,de Souza DO,Lara DR,Bonan CD

    更新日期：2005-02-21 00:00:00

  • Effect of chronic moderate ethanol consumption on heart brain natriuretic peptide.

    abstract：:There is experimental evidence indicating that chronic moderate ethanol consumption delays the age-dependent increase in blood pressure. Since the brain natriuretic peptide (BNP) is a potent hypotensive hormone, the effect of chronic ethanol treatment on the heart BNP system was investigated, using spontaneously hyper...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(96)00644-9

    authors： Guillaume P,Jankowski M,Gutkowska J,Gianoulakis C

    更新日期：1996-11-28 00:00:00

  • Evidence for an intramuscular depot of the cholinesterase inhibitor soman in the rat.

    abstract：:Isolated rat diaphragms were treated with the oxime HI-6, 25 min after the start of soman exposure for 5, 15, 20 or 25 min. Recovery of neuromuscular transmission (NMT) was smaller and the subsequent spontaneous failure of NMT greater when soman exposure was longer. Diaphragms taken from anaesthetized atropinized soma...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(83)90504-6

    authors： Van Helden HP,Wolthuis OL

    更新日期：1983-05-06 00:00:00

  • Cellular mechanism underlying hydrogen sulfide induced mouse tracheal smooth muscle relaxation: role of BKCa.

    abstract：:Recent studies have suggested that hydrogen sulfide (H2S), an important endogenous signaling gaseous molecule, participates in relaxation of smooth muscle. Nevertheless, the mechanism of this relaxation effect on respiratory system is still unclear. The present study aims to investigate the physiological function as w...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2014.07.004

    authors： Huang J,Luo YL,Hao Y,Zhang YL,Chen PX,Xu JW,Chen MH,Luo YF,Zhong NS,Xu J,Zhou WL

    更新日期：2014-10-15 00:00:00

  • Mixed type inhibition of [D-Ala2, D-Leu5]enkephalin binding to mu-opiate binding sites by mu-, but not by kappa-opiate ligands.

    abstract：:The interaction of the delta-opiate agonist [D-Ala2,D]Leu5]enkephalin (DADL) with the mu-opiate ligands dihydromorphine (DHM) and naloxone and the kappa-opiate ligand ethylketocyclazocine (EK) was studied in rat diencephalic membranes which contain mainly mu-opiate binding sites. Saturation binding experiments perform...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(82)90145-5

    authors： Pfeiffer A,Herz A

    更新日期：1982-02-05 00:00:00

  • Release of smooth muscle-contracting substances from isolated perfused lungs.

    abstract：:Infusion of tryptamine (1-4 mug/ml) through the pulmonary circulation of rat isolated lung perfused with Krebs solution caused release of a mixture of spasmogens contracting isolated smooth muscle preparations. One component of this mixture had biological activity comparable to E-type prostaglandins. Other components ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(76)90238-7

    authors： Alabaster VA,Bakhle YS

    更新日期：1976-02-01 00:00:00

  • Immunosuppressants enhance superoxide radical/nitric oxide-dependent dexamethasone suppression of ischemic paw edema in mice.

    abstract：:A possible new common action of immunosuppressants, besides suppression of the genes for cytokines like interleukin-2, was investigated in in vivo models. Dexamethasone (0.1 mg/kg, s.c.) failed to suppress ischemic paw edema in mice 1 h after its injection, but maximal suppression was achieved at 3 h (20%) whereafter ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01561-6

    authors： Oyanagui Y

    更新日期：1998-03-05 00:00:00

  • Inhibition of somato-sympathetic reflex via peripheral presynaptic alha-adrenoceptors.

    abstract：:In cats anaesthetized with chloralose--urethane (70/100 mg/kg) a somato-sympathetic reflex increase of blood pressure and heart rate was evoked by electrical stimulation of sensory fibres running within the tibial nerve. I.V. injection of 30 microgram/kg of the alpha-adrenoceptor agonist clonidine caused a reflex inhi...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(78)90392-8

    authors： Walland A

    更新日期：1978-01-15 00:00:00

  • Alpha-adrenergic regulation of the activity of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy.

    abstract：:The increases in activity of hepatic thymidylate synthetase and of thymidine kinase, which catalyze the formation of thymidylate via the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which had been given alpha-adrenoceptor antagonists (phenoxybenzamine and ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90380-2

    authors： Nakata R,Tsukamoto I,Nanme M,Makino S,Miyoshi M,Kojo S

    更新日期：1985-08-27 00:00:00

  • Reduced mucosal side-effects of acetylsalicylic acid after conjugation with tris-hydroxymethyl-aminomethane. Synthesis and biological evaluation of a new anti-inflammatory compound.

    abstract：:Acetylsalicylic acid (ASA) causes adverse haemorrhagic reactions in the upper gastrointestinal (GI) tract, and previous results have suggested that combination therapy with 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) could provide protection in this scenario. Based on this hypothesis, our aim was to develop a new...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2016.04.019

    authors： Varga G,Lajkó N,Ugocsai M,Érces D,Horváth G,Tóth G,Boros M,Ghyczy M

    更新日期：2016-06-15 00:00:00

  • Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity.

    abstract：:The differentiation-inducing factor-1 (DIF-1) is a signal molecule that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum. In addition, DIF-1 is a potent antileukemic agent that induces growth arrest in K562 cells. In this study, we investigated the mechanism of action of DIF-1 in ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2003.11.041

    authors： Akaishi E,Narita T,Kawai S,Miwa Y,Sasaguri T,Hosaka K,Kubohara Y

    更新日期：2004-02-06 00:00:00

  • Source of the elevation Ca2+ evoked by 15-HETE in pulmonary arterial myocytes.

    abstract：:We have previously reported that 15-hydroxyeicosatetraenoic acid (15-HETE), a metabolite of arachidonic acid by 15-lipoxygenase, causes pulmonary vasoconstriction via increasing the intracellular Ca(2+) concentration ([Ca(2+)]i). However, the multiple sources of Ca(2+) that contribute to Ca(2+) elevation during and af...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.10.028

    authors： Zheng X,Li Q,Tang X,Liang S,Chen L,Zhang S,Wang Z,Guo L,Zhang R,Zhu D

    更新日期：2008-12-28 00:00:00

  • In vivo efficiency of the collagen coated nanofibrous scaffold and their effect on growth factors and pro-inflammatory cytokines in wound healing.

    abstract：:Exploring the importance of nanofibrous scaffold with traditionally important medicine as a wound dressing material prevents infection and aids in faster healing of wounds. In the present study, the Collagen (COL) from the marine fish skin was extracted and employed for coating the Poly(3-hydroxybutyric acid) (P)-Gela...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2017.08.003

    authors： Ramanathan G,Muthukumar T,Tirichurapalli Sivagnanam U

    更新日期：2017-11-05 00:00:00

  • Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the mice.

    abstract：:Diabetic nephropathy (DN) is a major cause of end-stage renal disease and one of the most severe diabetic complications. However, there is lack of effective treatments for DN and the underlying mechanisms of the renal injury remain unclear. In current study, we evaluated the effects of silibinin on DN and further expl...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2018.12.031

    authors： Liu Y,Ye J,Cao Y,Zhang R,Wang Y,Zhang S,Dai W,Ye S

    更新日期：2019-02-15 00:00:00

  • Mitochondria, Ca2+ and neurodegenerative disease.

    abstract：:Mitochondria play a central role in cell biology not only as producers of ATP, but also in the sequestration of Ca(2+) and the generation of free radicals. They are also repositories of several proteins which regulate apoptosis. Perturbations in the normal functions of mitochondria will inevitably disturb cell functio...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/s0014-2999(02)01842-3

    authors： Krieger C,Duchen MR

    更新日期：2002-07-05 00:00:00

  • Antifibrillatory actions of bepridil and butyl-MDI, two intracellular calcium antagonists.

    abstract：:The antifibrillatory and electrophysiologic actions of bepridil and butyl-methylenedioxyindene (BU-MDI), two intracellular calcium antagonists, were examined in anesthetized dogs. The administration of bepridil (1.0-10.0 mg/kg i.v.) significantly increased the electrical threshold for ventricular fibrillation determin...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(85)90107-4

    authors： Lynch JJ,Rahwan RG,Lucchesi BR

    更新日期：1985-04-23 00:00:00

  • The regulation of mitochondrial respiration by opening of mKCa channels is age-dependent.

    abstract：:The protective potency of ischemic preconditioning decreases with increasing age. A key step in ischemic preconditioning is the opening of mitochondrial Ca(2+) sensitive K(+) (mK(Ca)) channels, which causes mild uncoupling of mitochondrial respiration. We hypothesized that aging reduces the effects of mK(Ca) channel o...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2007.09.008

    authors： Heinen A,Winning A,Schlack W,Hollmann MW,Preckel B,Frässdorf J,Weber NC

    更新日期：2008-01-14 00:00:00

  • Biphasic action of ethanol on contraction of skeletal muscle.

    abstract：:Ethanol (160-640 mM) produces a biphasic action on the indirectly stimulated rat phrenic nerve--diaphragm preparation. This consists of a potentiation followed by a blockade of muscle contraction. Concomitant with the increase in the force of contraction was the appearance of multiple neural action potentials recorded...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(75)90044-8

    authors： Cooper SA,Dretchen KL

    更新日期：1975-04-01 00:00:00

  • Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies.

    abstract：:The coronavirus disease-19 (COVID-19) outbreak that is caused by a highly contagious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a zoonotic pandemic, with approximately 24.5 million positive cases and 8.3 lakhs deaths globally. The lack of effective drugs or vaccine provoked the research fo...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2020.173688

    authors： M P,Reddy GJ,Hema K,Dodoala S,Koganti B

    更新日期：2021-01-05 00:00:00

  • Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor.

    abstract：:Several effects of bacterial endotoxins involve an opioid pathway and neuropeptide FF is an endogenous peptide known to modulate opioid activity, mainly in the central nervous system. The aim of this study was to investigate in rats the role of central neuropeptide FF receptors in intestinal motor disturbances and bod...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(97)01142-4

    authors： Million M,Fioramonti J,Zajac JM,Buéno L

    更新日期：1997-09-03 00:00:00

  • The effects of antidepressants and electroconvulsive shocks on the functioning of the mesolimbic dopaminergic system: a behavioral study.

    abstract：:The mesolimbic dopaminergic innervation is supposed to be involved in the mechanisms of central effects exerted by various classes of psychotropic drugs. Antidepressants have been found to interact with the brain dopaminergic system as well, although the precise central location of this interaction is unknown. Some da...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(87)90689-3

    authors： Plaznik A,Kostowski W

    更新日期：1987-03-31 00:00:00

  • Acid and stretch, but not capsaicin, are effective stimuli for ATP release in the porcine bladder mucosa: Are ASIC and TRPV1 receptors involved?

    abstract：:Stretch-evoked ATP release from the bladder mucosa is a key event in signaling bladder fullness. Our aim was to examine whether acid and capsaicin can also release ATP and to determine the receptors involved, using agonists and antagonists at TRPV1 and acid-sensing ion channels (ASICs). Strips of porcine bladder mucos...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2012.02.041

    authors： Sadananda P,Kao FC,Liu L,Mansfield KJ,Burcher E

    更新日期：2012-05-15 00:00:00

  • Differential effects of chronic dopamine D1 and D2 receptor agonists on rotational behavior and dopamine receptor binding.

    abstract：:The effects of chronic continuous and intermittent administration of the dopamine D1 receptor agonist SKF 38393 or the D2 receptor agonist quinpirole on rotational behavior and dopamine receptor binding were examined in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. Continuous and interm...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(93)90476-x

    authors： Engber TM,Marin C,Susel Z,Chase TN

    更新日期：1993-06-04 00:00:00

  • Substance P infusion into substantia nigra of the rat: behavioural analysis and involvement of striatal dopamine.

    abstract：:The purpose of the present study was to characterize the nature of the behavioural response to substance P (SP) infusion into the substantia nigra and to evaluate this response in 6-hydroxydopamine (6-OHDA) caudate lesioned rats. The effects of SP infusions (3 microgram in 1 microliter bilaterally) were assessed in an...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(79)90216-4

    authors： Kelley AE,Iversen SD

    更新日期：1979-12-07 00:00:00

  • Nitric oxide enhances prostaglandin production in ethanol-induced gastric mucosal injury in rats.

    abstract：:The interaction between endogenous nitric oxide (NO), elicited by administration of Escherichia coli lipopolysaccharide, and cyclooxygenase system, in ethanol-induced injury in rat gastric mucosa, was investigated. Administration of graded doses of lipopolysaccharide reduced the gastric mucosal injury in response to e...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0014-2999(98)00161-7

    authors： Franco L,Doria D

    更新日期：1998-05-08 00:00:00

  • Effect of diazepam on cerebral 5-hydroxytryptamine synthesis.

    abstract：:In the brains of normal and reserpinized rats both diazepam and amino-oxyacetic acid (AOAA) decreased the 5-hydroxytryptophan (5HTP) accumulation induced by the decarboxylase inhibitor 3-hydroxybenzylhydrazine (NSD 1015). In reserpinized animals, the action of diazepam was antagonized by picrotoxin and bicuculline in ...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/0014-2999(79)90200-0

    authors： Saner A,Pletscher A

    更新日期：1979-05-01 00:00:00

  • Sargaquinoic acid supports the survival of neuronal PC12D cells in a nerve growth factor-independent manner.

    abstract：:Sargaquinoic acid (designated previously as MC14) was isolated from a marine brown alga Sargassum macrocarpum, and has been found to possess a novel nerve growth factor (NGF)-dependent neurite outgrowth promoting activity in PC12D cells. In this study, we explored the neuroprotective effects of MC14 in terms of its su...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2004.01.033

    authors： Tsang CK,Kamei Y

    更新日期：2004-03-19 00:00:00

  • Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore.

    abstract：:Resveratrol pretreatment can protect the heart by inducing pharmacological preconditioning. Whether resveratrol protects the heart when applied at reperfusion remains unknown. We examined the effect of resveratrol on myocardial infarct size when given at reperfusion and investigated the mechanism underlying the effect...

    journal_title：European journal of pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.ejphar.2008.12.024

    authors： Xi J,Wang H,Mueller RA,Norfleet EA,Xu Z

    更新日期：2009-02-14 00:00:00