Abstract：
:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR than WKY. This difference in contractile response is known to occur in the prehypertensive period of SHR (4-week-old). Phentolamine (10(-6) M) pretreatment had no effect on the ouabain-induced contraction but partially suppressed it in both SHR and WKY aortas when diltiazem (10(-5) M) was also added. The difference in the ouabain-induced contractions of SHR and WKY aortas was more apparent in the residual contraction during suppression by diltiazem. The 45Ca uptake in the presence of ouabain was significantly larger in the early period of incubation in SHR aorta than in WKY aorta. The ouabain-induced contraction of hydralazine-treated SHR aorta from the prehypertensive period was very similar to that of non-treated WKY aorta. These results suggested that the abnormality of the ouabain-induced contraction in SHR arterial smooth muscle could have arisen from an increased Ca2+ movement due to Ca2+ leakage when ouabain inhibited the Na+-pump in the membrane. This abnormality seems to start during the prehypertensive period and continue in the hypertensive stage.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Ydoi
10.1016/0014-2999(88)90537-7subject
Has Abstractpub_date
1988-07-14 00:00:00pages
409-18issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(88)90537-7journal_volume
151pub_type
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