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The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.

Abstract：

:We investigated the role of K(ATP) channel on acute urinary retention (AUR) induced bladder dysfunction. Eight-week-old female Sprague-Dawley rats were divided into seven groups: a sham-operated control group, an AUR group, and five AUR groups treated with: two different K(ATP) channel openers namely nicorandil (3 or 10mg/kg), or cromakalim (100 or 300microg/kg), or one K(ATP) channel inhibitor namely glibenclamide (5mg/kg). The drugs were administered 30min before induction of AUR. After the urethra was obstructed with a clip, AUR was induced by intravesical infusion of 2.5ml of saline via cystostomy. Following a 30min obstruction the bladder was allowed to drain with a catheter in place for 60min with real-time monitoring of intravesical pressure and blood flow. After the experimental period, the bladder function was assessed, using organ bath techniques (carbachol and 100mM KCl). AUR increased the intravesical pressure and decreased the blood flow. The subsequent catheterization decreased the intravesical pressure and increased the blood flow. AUR group reduced significantly the contractile responses to both carbachol and KCl compared with the control group. Nicorandil and cromakalim but not glibenclamide prevented the bladder dysfunction after AUR suggesting that K(ATP) channel openers may prevent the bladder dysfunction caused by AUR and subsequent catheterization.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Ohmasa F,Saito M,Shimizu S,Taniguchi S,Dimitriadis F,Satoh I,Kinoshita Y,Satoh K

doi

10.1016/j.ejphar.2010.02.052

subject

Has Abstract

pub_date

2010-06-10 00:00:00

pages

194-7

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(10)00198-6

journal_volume

635

pub_type

杂志文章

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