Chronic treatment with citalopram facilitates the effect of a challenge dose on cortical serotonin output: role of presynaptic 5-HT1A receptors.

abstract：:The response to epithelium-derived relaxant factor (EpDRF) released from guinea-pig trachea by acetylcholine was studied in the precontracted rat anococcygeus muscle in a coaxial bioassay system. Acetylcholine caused no relaxation of rat anococcygeus muscle which was precontracted with phenylephrine. When the same mus...

journal_title：European journal of pharmacology

authors： Güc MO,Ilhan M,Kayaalp SO

更新日期：1988-04-13 00:00:00

abstract：:The antifibrillatory and electrophysiologic actions of bepridil and butyl-methylenedioxyindene (BU-MDI), two intracellular calcium antagonists, were examined in anesthetized dogs. The administration of bepridil (1.0-10.0 mg/kg i.v.) significantly increased the electrical threshold for ventricular fibrillation determin...

journal_title：European journal of pharmacology

authors： Lynch JJ,Rahwan RG,Lucchesi BR

更新日期：1985-04-23 00:00:00

abstract：:The effects of loxapine and its hydroxylated metabolites 7-hydroxyloxapine and 8-hydroxyloxapine on 3H-spiroperidol binding to rat striatal membranes were investigated. Whereas 7-hydroxyloxapine and loxapine displayed strong affinities for 3H-spiroperidol binding sites, 8-hydroxyloxapine was essentially inactive. The ...

journal_title：European journal of pharmacology

authors： Coupet J,Rauh CE

更新日期：1979-04-15 00:00:00

abstract：:A novel growth hormone secretagogues type 1a (GHS1a) receptors antagonist (2R)-N'-[3,5- bis(trifluoromethyl)phenyl]-2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-(3- pyridinyl)ethanohydrazide (GSK1614343) was functionally characterised in rat pituitary adenoma cell line, RC-4B/C endogenously expressing GHS1a rec...

journal_title：European journal of pharmacology

authors： Perdonà E,Faggioni F,Buson A,Sabbatini FM,Corti C,Corsi M

更新日期：2011-01-10 00:00:00

abstract：:Glutamine is the most abundant amino acid in the bloodstream. It is important in nucleotide synthesis, is anti-catabolic, has anti-oxidant properties via metabolism to glutathione, may enhance immune responsiveness and possesses immunoregulatory functions. Moreover, it reduces atrophy of intestinal mucosa in animals o...

journal_title：European journal of pharmacology

authors： Mondello S,Galuppo M,Mazzon E,Italiano D,Mondello P,Aloisi C,Cuzzocrea S

更新日期：2011-05-01 00:00:00

abstract：:The aim of this study was to correlate mineralocorticoid action and steroid structure. Inasmuch as Na(+) retention follows a parabolic dose-response curve for most pregnanesteroids, the second-order coefficient of the function was used as a representative factor for this bipartite biological effect. The C(3)=O/D angle...

journal_title：European journal of pharmacology

authors： Piwien-Pilipuk G,Kanelakis KC,Galigniana MD

更新日期：2002-11-15 00:00:00

abstract：:Gender-related differences in susceptibility to stress and stress-related disorders such as depression, and in response to treatment with antidepressants have been observed, but the underlying molecular mechanisms are still unknown. Considering the role of glucocorticoid hormones in the systemic reaction against stres...

journal_title：European journal of pharmacology

authors： Elaković I,Brkljacić J,Matić G

更新日期：2009-04-17 00:00:00

abstract：:In previous studies using Fos expression as a marker of neuronal activation, we showed that nitrous oxide (N(2)O) activates bulbospinal noradrenergic neurons in rats and that destruction of these neuronal pathways leads to loss of N(2)O antinociceptive action. Based on previous rat studies it has been proposed that th...

journal_title：European journal of pharmacology

authors： Kingery WS,Sawamura S,Agashe GS,Davies MF,Clark JD,Zimmer A

更新日期：2001-09-07 00:00:00

abstract：:alpha-Adrenoceptors have been classified into alpha(1)- and alpha(2)-adrenoceptors. Recently, the alpha(1)-adrenoceptors were divided into two subtypes: alpha(1L) with low affinity and alpha(1H) with high affinity for prazosin. Little is known concerning the role of each subtype of alpha(1)-adrenoceptor in asthma. We ...

journal_title：European journal of pharmacology

authors： Nobata K,Fujimura M,Ishiura Y,Hirose T,Furusyou S,Myou S,Kurashima K,Kasahara K,Nakao S

更新日期：2002-09-27 00:00:00

abstract：:The aim of present work was to investigate the underlying mechanism of vasculature-protecting effects of exercise training in aged rats. Experiment 1: aged rats were given moderate-intensity exercise for 12 weeks. Exercise training suppressed advanced glycation evidenced by reduced activity of aldose reductase, increa...

journal_title：European journal of pharmacology

authors： Gu Q,Wang B,Zhang XF,Ma YP,Liu JD,Wang XZ

更新日期：2014-10-15 00:00:00

abstract：:The NMDA receptor is coupled to a cation-selective ion channel, which has been implicated in important brain functions such as long-term potentiation and burst firing, and in neuronal death associated with stroke and epilepsy. We have investigated the binding properties of [3H]MK-801, which binds selectively to the op...

journal_title：European journal of pharmacology

authors： von Euler G,Liu Y

更新日期：1993-05-15 00:00:00

abstract：:Piperine, a main component of Piper longum Linn. and Piper nigrum Linn., is a plant alkaloid with a long history of medical use. Piperine exhibits anti-inflammatory activity; however, the underlying mechanism remains unknown. We examined the effects of piperine on lipopolysaccharide (LPS)-induced inflammatory response...

journal_title：European journal of pharmacology

authors： Bae GS,Kim MS,Jung WS,Seo SW,Yun SW,Kim SG,Park RK,Kim EC,Song HJ,Park SJ

更新日期：2010-09-10 00:00:00

abstract：:The characteristics of [3H](+)-pentazocine and [3H]1,3-di(2-tolyl) guanidine (DTG) binding to mouse whole brain, cortex, cerebellum and spinal cord membranes were investigated in radioreceptor assays. [3H](+)-Pentazocine bound to a single, high affinity site (Kd = 1.2-1.6 nM) with increasing density along the neuraxis...

journal_title：European journal of pharmacology

authors： Kovács KJ,Larson AA

更新日期：1995-10-16 00:00:00

abstract：:Carbocyclic thromboxane A2 (CTA2) constricted rabbit basilar and saphenous arteries. The contractions of the basilar artery, but not those of the saphenous artery, were potently inhibited by the calcium antagonist nimodipine. Selective inhibition of thromboxane-induced vasoconstriction of cerebral vessels may contribu...

journal_title：European journal of pharmacology

authors： Towart R,Perzborn E

更新日期：1981-01-16 00:00:00

abstract：:The effect of (+)-sotalol and deoxysotalol on prostaglandin (PGF2a and 15-methyl PGF2alpha)-evoked contractions was studied using the isolated rat uterus. After control responses to prostaglandins had been obtained the uterus was exposed to the nutrient fluid containing 10 microgram/ml of (+)-sotalol, deoxysotalol or ...

journal_title：European journal of pharmacology

authors： Narendranath KA,Sharma PL

更新日期：1977-11-01 00:00:00

abstract：:To determine the role of protein kinase C in the regulation of intestinal fluid transport, experiments were performed with the rat jejunum in vivo, using the active phorbol ester, 4-beta-phorbol 12-myristate 13-acetate (PMA), as stimulator of protein kinase C. Intraluminally administered PMA dose dependently reversed ...

journal_title：European journal of pharmacology

authors： Beubler E,Hinterleitner T,Horina G

更新日期：1990-07-17 00:00:00

abstract：:In WI-38 human fibroblasts, interleukin-1 beta and tumour necrosis factor-alpha (TNF-alpha) increased bradykinin B(1) receptor mRNA, which peaked between 2 and 4 h, remaining elevated for 20 h. Binding of the bradykinin B(1) receptor selective ligand [3H]des-Arg(10)-kallidin, also increased, peaking at 4 h and remaini...

journal_title：European journal of pharmacology

authors： Phagoo SB,Yaqoob M,Herrera-Martinez E,McIntyre P,Jones C,Burgess GM

更新日期：2000-06-02 00:00:00

abstract：:The objective of this study was to determine the in vivo effectiveness of the selective endothelin ETA receptor antagonist PD 156707 (sodium 2-benzo[1,3]dioxol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(3,4,5-trimet hoxy- benzyl)-but-2-enoate). Effectiveness was defined by the ability of the compound to block increases in ren...

journal_title：European journal of pharmacology

authors： Ignasiak DP,McClanahan TB,Saganek LJ,Potoczak RE,Hallak H,Gallagher KP

更新日期：1997-03-05 00:00:00

abstract：:The effects of ICS 205-930 [3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester), an antagonist of 5-HT at neuronal M receptors, were examined in anaesthetised greyhounds subject to acute coronary artery occlusion and reperfusion. Intravenous administration of 0.3 or 2.0 mg kg-1 of ICS 205-930 did not significantly al...

journal_title：European journal of pharmacology

authors： Coker SJ,Dean HG,Kane KA,Parratt JR

更新日期：1986-08-15 00:00:00

abstract：:The present study investigated the changes in NMDA receptor subunit proteins in diazepam-withdrawn rat cerebral cortex, using Western blotting analysis. The protein levels of the NR1 and NR2B, but not NR2A, subunits were significantly increased in diazepam-withdrawn rats compared to those in control rats. Therefore, a...

journal_title：European journal of pharmacology

authors： Tsuda M,Chiba Y,Suzuki T,Misawa M

更新日期：1998-01-12 00:00:00

abstract：:Several antimalarial drugs are known to produce a QT interval prolongation via a blockade of the rapidly activating delayed rectifier K+ current (IKr), encoded by the human-ether-a-go-go-related gene (hERG). We investigated the influence of lumefantrine and its major metabolite desbutyl-lumefantrine, as well as halofa...

journal_title：European journal of pharmacology

authors： Traebert M,Dumotier B,Meister L,Hoffmann P,Dominguez-Estevez M,Suter W

更新日期：2004-01-19 00:00:00

abstract：:The failure of alpha 1-adrenoceptor antagonists, prazosin and indoramin, to cause a reflex tachycardia was investigated in the anaesthetised cat. Recordings were made of preganglionic sympathetic nerve activity from the third or fourth white ramus communicans, femoral arterial conductance, heart rate and blood pressur...

journal_title：European journal of pharmacology

authors： Ramage AG

更新日期：1984-11-27 00:00:00

abstract：:Dipeptidyl peptidase-4 (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes by increasing plasma active glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide levels. However, the effects of chronic DPP-4 inhibition on in vivo beta-cell function are poorly characterize...

journal_title：European journal of pharmacology

authors： Moritoh Y,Takeuchi K,Asakawa T,Kataoka O,Odaka H

更新日期：2008-07-07 00:00:00

abstract：:The tertiary nitrogen derivatives of two choline esters, chloroacetylcholine and acrylcholine, known to inhibit choline acetyltransferase (ChAc) in vitro, were tested for their effects in the whole animal, including peripheral and central cholinergic systems. These esters are N,N-dimethylaminoethyl chloroacetate (Cl-D...

journal_title：European journal of pharmacology

authors： Rowell PP,Chiou CY

更新日期：1976-11-01 00:00:00

abstract：:The effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a thromboxane A2 synthase inhibitor, on eosinophil accumulation and activation were investigated in an experimental asthmatic guinea pig model and several cellular models. In the in vivo studies, CS-518 inhibited the bip...

journal_title：European journal of pharmacology

authors： Itoh K,Mukaiyama O,Satoh Y,Yamaguchi T,Iizuka Y

更新日期：1993-08-03 00:00:00

abstract：:Transcriptional activation of the human CYP1A1 gene (coding for cytochrome P450 1A1) is mediated by the aryl hydrocarbon receptor. In the present study we have examined interaction of the ginsenoside Rg1 and Rb1 with the carcinogen activation pathway mediated by the aryl hydrocarbon receptor in HepG2 cells. RT-PCR was...

journal_title：European journal of pharmacology

authors： Wang Y,Ye X,Ma Z,Liang Q,Lu B,Tan H,Xiao C,Zhang B,Gao Y

更新日期：2008-12-28 00:00:00

abstract：:The anticonvulsant mood stabilizers valproic acid (250, 500 but not 50 mg/kg) and carbamazepine (6, 12.5 but not 3 mg/kg) were found to increase extracellular dopamine levels in rat medial prefrontal cortex, but not nucleus accumbens. Increased prefrontal dopamine was completely abolished by the selective 5-HT1A recep...

journal_title：European journal of pharmacology

authors： Ichikawa J,Meltzer HY

更新日期：1999-09-03 00:00:00

abstract：:The effect of NIK-247 on carbon monoxide (CO)-induced amnesia were investigated. A step-down type passive avoidance task with mice was used to compare the effects of NIK-247 with those of tacrine. Two types of CO-induced amnesia model, acute and delayed models, were used. The acute amnesia model was developed using mi...

journal_title：European journal of pharmacology

authors： Yoshida S,Nabeshima T,Kinbara K,Kameyama T

更新日期：1992-04-22 00:00:00

abstract：:A decrease of 30% was observed in the density of peripheral-type benzodiazepine binding sites in platelets of nine schizophrenics maintained on chronic neuroleptic treatment as compared to platelets of six untreated schizophrenics and 15 healthy volunteers. The equilibrium dissociation constant for binding by [3H]PK 1...

journal_title：European journal of pharmacology

authors： Gavish M,Weizman A,Karp L,Tyano S,Tanne Z

更新日期：1986-02-18 00:00:00

abstract：:We explored the effects of contractile arrest maintained for 24-72 h in the presence of 2,3-butanedione monoxime or a Ca(2+) channel blocker (nifedipine or verapamil) on contractile activity, Ca(i)(2+) transients, and myofibrillar protein content and ultrastructure in long-term cultures of spontaneously beating adult ...

journal_title：European journal of pharmacology

authors： Horackova M,Byczko Z,Morash B

更新日期：2000-09-22 00:00:00