Abstract:
:The effect of (+)-sotalol and deoxysotalol on prostaglandin (PGF2a and 15-methyl PGF2alpha)-evoked contractions was studied using the isolated rat uterus. After control responses to prostaglandins had been obtained the uterus was exposed to the nutrient fluid containing 10 microgram/ml of (+)-sotalol, deoxysotalol or (--) sotalol. 30 min later the responses to prostaglandins were again recorded. Both (+)-sotalol and deoxysotalol potentiated PGF2alpha as well as 15-methyl PGF2alpha-induced contractions. (--)-Sotalol did not potentiate the PGF2alpha-evoked contractions of the isolated rat uterus. The possible clinical significance of the results is discussed.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Narendranath KA,Sharma PLdoi
10.1016/0014-2999(77)90138-8subject
Has Abstractpub_date
1977-11-01 00:00:00pages
15-9issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(77)90138-8journal_volume
46pub_type
杂志文章abstract::The treatment of rat thymocytes with 10 microM terfenadine resulted in a significant increase in DNA fragmentation. The DNA fragmentation induced by terfenadine was dependent on its concentration and incubation time. In terfenadine-treated cells, the translocation of phosphatidylserine from the inside of plasma membra...
journal_title:European journal of pharmacology
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abstract::Clinical evidence indicates an antiarrhythmic effect of sulfonylureas, which might be blunted by their vascular action. We wanted to investigate the effect of glibenclamide and the new sulfonylthiourea compound 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]-sulfonyl]-3 -me thylthiourea (HMR1883) on cardiac ele...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
pub_type: 杂志文章
doi:10.1016/0014-2999(90)90312-t
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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