Potentiating effect of (+)-sotalol and deoxysotalol on prostaglandin-evoked contractions of the isolated rat uterus.

Abstract:

:The effect of (+)-sotalol and deoxysotalol on prostaglandin (PGF2a and 15-methyl PGF2alpha)-evoked contractions was studied using the isolated rat uterus. After control responses to prostaglandins had been obtained the uterus was exposed to the nutrient fluid containing 10 microgram/ml of (+)-sotalol, deoxysotalol or (--) sotalol. 30 min later the responses to prostaglandins were again recorded. Both (+)-sotalol and deoxysotalol potentiated PGF2alpha as well as 15-methyl PGF2alpha-induced contractions. (--)-Sotalol did not potentiate the PGF2alpha-evoked contractions of the isolated rat uterus. The possible clinical significance of the results is discussed.

journal_name

Eur J Pharmacol

authors

Narendranath KA,Sharma PL

doi

10.1016/0014-2999(77)90138-8

subject

Has Abstract

pub_date

1977-11-01 00:00:00

pages

15-9

issue

1

eissn

0014-2999

issn

1879-0712

pii

0014-2999(77)90138-8

journal_volume

46

pub_type

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