Valproate and carbamazepine increase prefrontal dopamine release by 5-HT1A receptor activation.

abstract：:Inhibitors of phosphodiesterases 3 and 4, the main cyclic AMP (cAMP) degrading enzymes in arteries, may have therapeutic potential in cerebrovascular disorders. We analysed the effects of such phosphodiesterases in guinea pig cerebral arteries with organ bath technique and cyclic nucleotide assays. Guinea pig and huma...

journal_title：European journal of pharmacology

authors： Birk S,Edvinsson L,Olesen J,Kruuse C

更新日期：2004-04-05 00:00:00

abstract：:The effects of capsaicin pretreatment on withdrawal responses of guinea-pig isolated ileum to [Met5]enkephalin (ME) and morphine and on the locomotor withdrawal response of guinea-pigs following a single dose of morphine, were investigated. In vitro treatment of ileum with capsaicin, 1.5 mumol/l for 1 h, did not signi...

journal_title：European journal of pharmacology

authors： Chahl LA

更新日期：1988-12-06 00:00:00

abstract：:Increasing evidence indicates that brain inflammation is involved in the pathogenesis of neuropsychiatric diseases. Mast cells (MCs) are located perivascularly close to neurons and microglia, primarily in the leptomeninges, thalamus, hypothalamus and especially the median eminence. Corticotropin-releasing factor (CRF)...

journal_title：European journal of pharmacology

authors： Theoharides TC,Stewart JM,Panagiotidou S,Melamed I

更新日期：2016-05-05 00:00:00

abstract：:Gastric vascular responses to histamine and its selective H1- and H2-agonists in vitro were investigated in the isolated vascular-perfused stomach of rabbit and rat. In the rabbit stomach under resting conditions bolus injection of histamine (5-80 nmol) caused a small increase in perfusion pressure (PP). However, duri...

journal_title：European journal of pharmacology

authors： Salvati P,Whittle BJ

更新日期：1983-04-22 00:00:00

abstract：:Stem cells have high potential for cell therapy in regenerative medicine. We previously isolated stem cell types from human amniotic fluid, derived from prenatal amniocentesis. One type, characterized by a fast doubling time, was designated as fast human amniotic stem cells (fHASCs). These cells exhibited high differe...

journal_title：European journal of pharmacology

authors： Romani R,Manni G,Donati C,Pirisinu I,Bernacchioni C,Gargaro M,Pirro M,Calvitti M,Bagaglia F,Sahebkar A,Clerici G,Matino D,Pomili G,Di Renzo GC,Talesa VN,Puccetti P,Fallarino F

更新日期：2018-08-15 00:00:00

abstract：:The effect of chronic administration of various monoamine oxidase (MAO) inhibitors on the ability of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) to inhibit forskolin-stimulated adenylate cyclase activity was studied. Groups of 12 rats were given either saline, (E)-beta-fluoromethylene-m-tyrosine (MDL 72394 0.25...

journal_title：European journal of pharmacology

authors： Sleight AJ,Marsden CA,Palfreyman MG,Mir AK,Lovenberg W

更新日期：1988-09-23 00:00:00

abstract：:In superfusion experiments with a crude synaptosomal fraction from the nucleus accumbens of rats, lysergic acid diethylamide, mescaline and N,N-dimethyltryptamine (representing different chemical classes of psychotomimetics) produced a concentration-related inhibition of K+-evoked [3H]dopamine release whereas spontane...

journal_title：European journal of pharmacology

authors： Hetey L,Schwitzkowsky R,Oelssner W

更新日期：1983-09-30 00:00:00

abstract：:Helicobacter pylori (H. pylori) and nonsteroidal anti-inflammatory drugs (NSAID) are the most common pathogens in the gastroduodenal mucosa in animals and humans, but their relationship in ulcerogenesis has been little studied. According to some authors, H. pylori infection in humans does not act synergistically with ...

journal_title：European journal of pharmacology

authors： Pawlik T,Konturek PC,Konturek JW,Konturek SJ,Brzozowski T,Cześnikiewicz M,Plonka M,Bielanski W,Areny H

更新日期：2002-08-02 00:00:00

abstract：:The [3H]nitrendipine binding activity of sarcolemmal fragments isolated from aerobically perfused or ischemic rat hearts was studied. After 90 min aerobic perfusion, two populations of binding sites were detected--high affinity sites with KD of 0.24 +/- 0.04 nM and Bmax 313 +/- 110 fmol/mg protein, and low affinity si...

journal_title：European journal of pharmacology

authors： Nayler WG,Dillon JS,Elz JS,McKelvie M

更新日期：1985-09-10 00:00:00

abstract：:Dose-response curves for morphine (0.5-20 mg/kg) were obtained in 4 rhesus monkeys performing the discrete trials shock titration task. Naloxone (5-500 microgram/kg) uniformly produced a dose dependent, parallel shift of the morphine dose-response curves to right. Plots for the 4 animals of the Log (dose ratio--1) ver...

journal_title：European journal of pharmacology

authors： Yaksh TL,Rudy TA

更新日期：1977-11-15 00:00:00

abstract：:The present study examined the effects of histamine on somatostatin-like immunoreactivity levels, binding of 125I-[Tyr11]somatostatin to its specific receptors, somatostatin inhibition of basal and forskolin-stimulated adenylyl cyclase activity and inhibitory guanine-nucleotide binding protein (Gi) function in the rat...

journal_title：European journal of pharmacology

authors： Puebla L,Arilla E

更新日期：1995-04-28 00:00:00

abstract：:The spontaneous and electrically evoked activity was examined in guinea-pig, ferret and marmoset urinary bladder. Electrical field stimulation of detrusor strips in vitro induced a rapid, frequency-dependent contraction with a maximum response at 40 Hz. This contraction was partly decreased by either atropine (0.29 mi...

journal_title：European journal of pharmacology

authors： Moss HE,Burnstock G

更新日期：1985-08-27 00:00:00

abstract：:In the present study, we investigated whether copper ions are involved in the decomposition of endogenous S-nitrosothiols by ultraviolet (UV) light irradiation in the mouse gastric fundus. The effects of copper ions and chelators of copper(I) and copper(II), neocuproine and cuprozine, respectively, were studied on rel...

journal_title：European journal of pharmacology

authors： Ogülener N,Ergün Y

更新日期：2004-02-06 00:00:00

abstract：:Inhibition by antipsychotic drugs of voltage-gated L-type Ca2+ channels was characterized in rat neuronal cell line pheochromocytoma PC12 cells. Under whole-cell voltage-clamp, haloperidol and chlorpromazine (1-100 microM) inhibited Ba2+ current permeating through Ca2+ channels. Fluspirilene and pimozide the Ba2+ curr...

journal_title：European journal of pharmacology

authors： Ito K,Nakazawa K,Koizumi S,Liu M,Takeuchi K,Hashimoto T,Ohno Y,Inoue K

更新日期：1996-10-24 00:00:00

abstract：:Sprague-Dawley rats were trained to discriminate a subcutaneous injection of physostigmine (0.2 mg/kg) from a similar injection of saline in a two-lever, food-reinforced behavior paradigm. The training dose of physostigmine reduced the response rate to about 50% of that in saline sessions. The discriminative stimulus ...

journal_title：European journal of pharmacology

authors： Tang AH,Franklin SR

更新日期：1988-08-09 00:00:00

abstract：:Antiepileptic and antidepressant drugs are the primary treatments for pain relief in diabetic neuropathy. Combination therapy is a valid approach in pain treatment, where a reduction of doses could reduce side effects and still achieve optimal analgesia. We examined the effects of two-drug combinations of gabapentin, ...

journal_title：European journal of pharmacology

authors： Tomić MA,Vucković SM,Stepanović-Petrović RM,Micov AM,Ugresić ND,Prostran MS,Bosković B

更新日期：2010-02-25 00:00:00

abstract：:Primary cultures of rat cerebellar granule cells are shown to possess a high density (283 +/- 48 fmol/mg of protein) of muscarinic receptor sites, defined using N-[3H]methylscopolamine [( 3H]NMS), with a KD of 0.18 +/- 0.01 nM measured after culture in vitro for 7 days. Displacement of specific [3H]NMS binding demonst...

journal_title：European journal of pharmacology

authors： Whitham EM,Challiss RA,Nahorski SR

更新日期：1991-03-25 00:00:00

abstract：:Inflammation, closely associated with obesity, is emerging as an important risk factor for the pathophysiological development of atherosclerosis and diabetes mellitus. Fat balance is critical in the aetiology of obesity. Lipoprotein lipase is an important enzyme in lipid metabolism. The aim of this study was to invest...

journal_title：European journal of pharmacology

authors： Cai M,Yin W,Li Q,Liao D,Tsutsumi K,Hou H,Liu Y,Zhang C,Li J,Wang Z,Xiao J

更新日期：2006-07-01 00:00:00

abstract：:Ryanodine at nanomolar concentrations suppressed the earlier of two contraction components which can be produced in guinea-pig papillary muscles, in the presence of noradrenaline (3 microM) at a low contraction frequency (0.2 Hz). However, test contractions elicited shortly after a steady state contraction showed an u...

journal_title：European journal of pharmacology

authors： Vierling W

更新日期：1988-01-19 00:00:00

abstract：:Several structural analogs of mazindol were tested as inhibitors of the uptake of [3H] dopamine in rat neostriatum, of [3H] norepinephrine in rat occipital cortex and of [3H] serotonin in whole rat brain. A rather wide range of potencies was observed but a number of the drugs were even more potent than mazindol as upt...

journal_title：European journal of pharmacology

authors： Heikkila RE,Babington RG,Houlihan WJ

更新日期：1981-05-08 00:00:00

abstract：:Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene) is a polyphenol present in grapes and wine. By means of alkaline phosphatase activity and osteocalcin enzyme-linked immunosorbent assay (ELISA), we have shown that piceatannol exhibits a significant induction of differentiation in immortalized fetal osteoblasts (hFOB...

journal_title：European journal of pharmacology

authors： Chang JK,Hsu YL,Teng IC,Kuo PL

更新日期：2006-12-03 00:00:00

abstract：:Oral methylnalorphine ( methylnalorphinium ) caused a dose-dependent selective inhibition of inflammatory hyperalgesia (measured in the rat by a modified version of the Randall- Selitto test) without affecting the oedema. When subcutaneously injected, repeated doses of morphine for 5 days caused progressive analgesic ...

journal_title：European journal of pharmacology

authors： Ferreira SH,Lorenzetti BB,Rae GA

更新日期：1984-03-16 00:00:00

abstract：:Peripheral type benzodiazepine receptors are differentially modified by arachidonate, diethylpyrocarbonate and thiol reagents, as evidenced by the finding that binding of a proposed agonist ([3H]R05-4864) and a proposed antagonist ([3H]PK 11195) to rat kidney mitochondrial membranes can be modified separately. (1) Ara...

journal_title：European journal of pharmacology

authors： Skowroński R,Beaumont K,Fanestil DD

更新日期：1987-11-17 00:00:00

abstract：:The effect of lidocaine on alpha 1-adrenoceptors in cultured neonatal rat ventricular cardiocytes was studied by binding assay. When the cells were cultured in the presence of lidocaine, the binding of (+/-)-beta-([125I]iodo-4-hydroxyphenyl)-ethyl-aminomethyl-tetralone to the cells increased in a concentration- and ti...

journal_title：European journal of pharmacology

authors： Mizuki T,Kobayashi H,Nakashima Y,Kuroiwa A,Izumi F

更新日期：1995-04-24 00:00:00

abstract：:This study evaluated the coronary dopamine receptors by using the dopamine D1 receptor agonist fenoldopam, dopamine D2 receptor agonist propylbutyldopamine, and their selective antagonists SCH23390 and domperidone. Left circumflex coronary flow (CF), coronary perfusion pressure at constant flow, left ventricular hemod...

journal_title：European journal of pharmacology

authors： Zhao RR,Fennell WH,Abel FL

更新日期：1990-11-06 00:00:00

abstract：:Blockade of sodium channels located in the sinoatrial node can slow diastolic depolarisation rate, recorded in vitro. The objective was therefore to determine whether these blockers could slow heart rate in vivo. The heart rate was firstly measured in spontaneously beating, isolated rat heart atria in the presence of ...

journal_title：European journal of pharmacology

authors： Létienne R,Vié B,Le Grand B

更新日期：2006-01-20 00:00:00

abstract：:This study was designed to investigate the effects of serotonin on changes in intracellular Ca(2+) concentration ([Ca(2+)](i)) in cultured rat heart endothelial cells. Serotonin stimulated a biphasic change in cytosolic Ca(2+) of rat heart endothelial cells: an initial transient increase, which primarily reflects the ...

journal_title：European journal of pharmacology

authors： Lee HZ,Wu CH

更新日期：1999-11-12 00:00:00

abstract：:Identification of the roles of epigenetic alterations in cancers has suggested that different molecules involved in this process are potentially therapeutic targets. Given the role of histone deacetylases (HDACs) enzymes in leukemogenesis, we designed a study to investigate the anti-leukemic property of panobinostat, ...

journal_title：European journal of pharmacology

authors： Mehrpouri M,Safaroghli-Azar A,Pourbagheri-Sigaroodi A,Momeny M,Bashash D

更新日期：2020-05-15 00:00:00

abstract：:Our purpose was to verify if alcohol causes alterations on translocation of Ca(2+) and tension induced by KCl or noradrenaline in vas deferens of periadolescent Wistar rats. A single dose of alcohol (i.p. 3.0g/kg) or saline as control, was given 4h before sacrifice. Longitudinal strips of prostatic portion were mounte...

journal_title：European journal of pharmacology

authors： Ferreira Verde L,Silva Lopes G,Miki Ihara SS,Hyppolito Jurkiewicz N,Jurkiewicz A

更新日期：2014-07-15 00:00:00

abstract：:The effect of intrathecal clonidine on thermal nociception and hindlimb flexion was assessed in acute and chronic spinally transected rats. After an acute, 1-day spinalization, there was no change in the antinociceptive dose-response function to clonidine, relative to intact rats. However, there was a significant incr...

journal_title：European journal of pharmacology

authors： Advokat C

更新日期：2002-02-15 00:00:00