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Influence of psychotomimetics and lisuride on synaptosomal dopamine release in the nucleus accumbens of rats.

Abstract：

:In superfusion experiments with a crude synaptosomal fraction from the nucleus accumbens of rats, lysergic acid diethylamide, mescaline and N,N-dimethyltryptamine (representing different chemical classes of psychotomimetics) produced a concentration-related inhibition of K+-evoked [3H]dopamine release whereas spontaneous release remained unchanged. The nonpsychotomimetic ergoline lisuride tested at the same concentration range did not modulate spontaneous or K+-evoked [3H]dopamine release. The inhibitory effects of the psychotomimetics tested were antagonized by equal concentrations of haloperidol or methiothepine. It is postulated that the effects of psychotomimetics on DA release were triggered via simultaneous action at presynaptic dopamine and 5-hydroxytryptamine receptors which are located at dopamine nerve endings in the nucleus accumbens.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Hetey L,Schwitzkowsky R,Oelssner W

doi

10.1016/0014-2999(83)90140-1

subject

Has Abstract

pub_date

1983-09-30 00:00:00

pages

213-20

issue

3-4

eissn

0014-2999

issn

1879-0712

pii

0014-2999(83)90140-1

journal_volume

93

pub_type

杂志文章

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