Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats.

abstract：:Recent studies show that 8-iso-prostaglandin F(2alpha), a member of F(2)-isoprostane family, acts as a vasoconstrictor via TP receptor activation; and its local release may contribute to an abnormal vasomotor tone associated with hypercholesterolemia. The purpose of this study was to examine whether ramatroban, a TP r...

journal_title：European journal of pharmacology

authors： Ishizuka T,Matsui T,Kurita A

更新日期：2003-05-02 00:00:00

abstract：:Silybin is a flavonoid with antioxidant and free radical scavenging abilities. Silybin also acts as an iron chelator by binding Fe (III). The present study was undertaken to assess the biological effects of silybin on T leukemia cells in the presence or absence of iron and compare its effects with a well-known iron ch...

journal_title：European journal of pharmacology

authors： Gharagozloo M,Khoshdel Z,Amirghofran Z

更新日期：2008-07-28 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is one of the risk factors for Parkinson's disease (PD). Insulin desensitisation has been observed in the brains of patients, which may promote neurodegeneration. Incretins are a family of growth factors that can re-sensitise insulin signalling. We have previously shown that mimetics of...

journal_title：European journal of pharmacology

authors： Yuan Z,Li D,Feng P,Xue G,Ji C,Li G,Hölscher C

更新日期：2017-10-05 00:00:00

abstract：:Histogranin, was co-purified with bombesin-like immunoreactive peptides from bovine adrenal medulla. Its structure, H-Met-Asn-Tyr-Ala-Leu-Lys-Gly-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-COOH, was determined by gas-phase Edman degradation. It was in accordance with its amino acid composition and corresponded to a 15 amino acid...

journal_title：European journal of pharmacology

authors： Lemaire S,Shukla VK,Rogers C,Ibrahim IH,Lapierre C,Parent P,Dumont M

更新日期：1993-05-15 00:00:00

abstract：:The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM...

journal_title：European journal of pharmacology

authors： Fujita R,Tamazawa Y,Barnard EA,Matsumoto M

更新日期：1993-08-24 00:00:00

abstract：:These studies examined the opioid and non-opioid in vivo and in vitro actions of PD117,302 (((±)-trans-N-methyl-N-[2-(l-pyrrolidinyl)-cyclohexyl]benzo[b]thiophene-4-acetamide), a kappa (κ)-opioid receptor agonist. PD117,302 selectively labeled the κ-opioid receptor in guinea pig cerebellar membranes and in mice the ED...

journal_title：European journal of pharmacology

authors： Pugsley MK,Saint DA,Hayes ES,Abraham S,Walker MJ

更新日期：2015-08-15 00:00:00

abstract：:The stimulation of spinal cannabinoid type 2 (CB(2)) receptors is a suitable strategy for the alleviation of experimental pain symptoms. Several reports have described the up-regulation of spinal cannabinoid CB(2) receptors in neuropathic settings together with the analgesic effects derived from their activation. Besi...

journal_title：European journal of pharmacology

authors： Curto-Reyes V,Boto T,Hidalgo A,Menéndez L,Baamonde A

更新日期：2011-10-01 00:00:00

abstract：:To investigate the mechanism underlying sulpiride-induced catalepsy, we simultaneously examined cataleptic behavior and the kinetics of the dopamine receptor antagonist, sulpiride of dopamine, and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), using in vivo voltammetry. After intrastriatal administrat...

journal_title：European journal of pharmacology

authors： Horikawa HP,Nakazato T,Hikosaka O

更新日期：1997-05-12 00:00:00

abstract：:"Non-adrenoceptor'-binding sites for [3H]clonidine (I1-sites) and [3H]idazoxan (I2-sites) are identified in calf striatum membranes. The pharmacological profile of both subtypes was investigated by competition binding with the imidazolines idazoxan, cirazoline, Bu 224 (2-(4,5-dihydroimidaz-2-yl)-quinoline) and Bu 239 ...

journal_title：European journal of pharmacology

authors： Czerwiec E,De Backer JP,Flamez A,Vauquelin G

更新日期：1996-11-07 00:00:00

abstract：:The new dihydropyridine calcium channel antagonist S 11568 and its optical isomers, S 12967 and S 12968 (3 x 10(-6) to 10(-4) M), caused, unlike nifedipine (10(-4) M), equipotent and rapid endothelium-dependent relaxations and increased the content of cyclic GMP in rings of canine femoral arteries. These effects were ...

journal_title：European journal of pharmacology

authors： Vilaine JP,Biondi ML,Villeneuve N,Feletou M,Peglion JL,Vanhoutte PM

更新日期：1991-05-02 00:00:00

abstract：:Microglia initially undergo rapid activation in response to injury and stressful stimuli, such as hypoxia. Oxidative stress and the inflammatory response play critical roles in hypoxic-ischemic brain injury. Carvedilol is a β-blocker used to treat high blood pressure and heart failure. In this study, we investigated w...

journal_title：European journal of pharmacology

authors： Gao X,Wu B,Fu Z,Zhang Z,Xu G

更新日期：2017-11-05 00:00:00

abstract：:Electrically stimulated release of [3H]dopamine [( 3H]DA) in slices of rat striatum was dose dependently inhibited by apomorphine (67% maximal inhibition) with an EC50 of 17 nM. DA receptor inactivation with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ; 0.5 and 2 mg/kg) dose dependently shifted the ED50 for ap...

journal_title：European journal of pharmacology

authors： Yokoo H,Goldstein M,Meller E

更新日期：1988-10-18 00:00:00

abstract：:Cholera toxin, stereotaxically injected into the medial septal nucleus of the rat, leads within 24 h to a dramatic decrease in body weight and an increase in septal adenylate cyclase activity. Toxin-treated rats drink one-third the water of vehicle-treated animals while excreting two-and-one half times the urine. Food...

journal_title：European journal of pharmacology

authors： Neckers LM,Neff NH,Garrison-Gund CK,Wyatt RJ

更新日期：1978-09-15 00:00:00

abstract：:Beta-lactoglobulin (BLG)-derived peptides may facilitate oral tolerance to whey and prevent cow's milk allergy (CMA). Loading of BLG-peptides in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Pep-NP) may improve this. Here we studied the uptake of NP and the capacity of NP and Pep-NP to activate bone marrow dendr...

journal_title：European journal of pharmacology

authors： Kostadinova AI,Middelburg J,Ciulla M,Garssen J,Hennink WE,Knippels LMJ,van Nostrum CF,Willemsen LEM

更新日期：2018-01-05 00:00:00

abstract：:The effects of a potent non-steroidal antiinflammatory drug, indomethacin, on the inflammatory response and lymphocyte proliferation were investigated in adjuvant-arthritic rats. As shown by others, adjuvant produced a time-dependent swelling of the contralateral paw which was maximal within 14 days after administrati...

journal_title：European journal of pharmacology

authors： Seng GF,Benensohn J,Bayer BM

更新日期：1990-03-27 00:00:00

abstract：:Galloyl group-containing catechins, such as epigallocatechin-3 gallate, inhibit receptor tyrosine kinase activity of several growth factor receptors. This study investigated the effects of epigallocatechin-3 gallate, as compared to epicatechin, on vascular endothelial growth factor-induced intracellular signaling and ...

journal_title：European journal of pharmacology

authors： Neuhaus T,Pabst S,Stier S,Weber AA,Schrör K,Sachinidis A,Vetter H,Ko YD

更新日期：2004-01-12 00:00:00

abstract：:The responsiveness of the guinea-pig esophageal muscularis mucosae to arachidonic acid (AA) and its cyclooxygenase and lipoxygenase metabolites was examined in vitro. AA (0.1-30 microM) produced a concentration-dependent contraction of the muscularis mucosae (mean EC50 +/- S.E.M. = 5.1 +/- 1.0 microM). The contraction...

journal_title：European journal of pharmacology

authors： Kamikawa Y,Fujinuma S,Shimo Y

更新日期：1985-08-07 00:00:00

abstract：:In order to identify functional sulphonylurea receptor (SUR.x) subunits of native ATP-sensitive K+ channels (KATP channels) in mouse portal vein, the effects of ZD0947, a SUR.x modulator, were investigated on spontaneous portal vein contractions, macroscopic membrane currents and unitary currents recorded (using patch...

journal_title：European journal of pharmacology

authors： Yamamoto T,Takahara K,Uchida K,Teramoto N

更新日期：2017-04-05 00:00:00

abstract：:Acanthoic acid, a pimaradiene diterpene isolated from Acanthopanax koreanum, has been reported to have anti-inflammatory activities. However, the effects of acanthoic acid on LPS-induced acute lung injury have not been reported. The purpose of this study was to investigate the protective effect of acanthoic acid on LP...

journal_title：European journal of pharmacology

authors： Qiushi W,Guanghua L,Guangquan X

更新日期：2015-03-05 00:00:00

abstract：:COVID-19 pandemic presents an unprecedented challenge to identify effective drugs for treatment. Despite multiple clinical trials using different agents, there is still a lack of specific treatment for COVID-19. Having the potential role in suppressing inflammation, immune modulation, antiviral and improving respirato...

journal_title：European journal of pharmacology

authors： Monji F,Al-Mahmood Siddiquee A,Hashemian F

更新日期：2020-11-15 00:00:00

abstract：:The action of a novel 5-HT3 receptor antagonist, AS-5370, has been studied on two electrophysiological models for 5-HT3 receptors: whole-cell patch-clamp recordings from mouse neuroblastoma-rat glioma (NG108-15) cells and grease-gap recordings from rat isolated vagus nerve. The 5-hydroxytryptamine (5-HT)-induced fast ...

journal_title：European journal of pharmacology

authors： Newberry NR,Sprosen TS,Watkins CJ,Leslie RA,Grahame-Smith DG

更新日期：1992-08-14 00:00:00

abstract：:The spasmogenic activity of caffeine (10 mM) was evaluated in tracheal strips obtained from control and sensitized guinea-pigs then pretreated with indomethacin (2.8 microM) and cooled to 20 degrees C. The contraction elicited by caffeine was inhibited by verapamil (100 microM), trifluoperazine (100 and 500 microM) an...

journal_title：European journal of pharmacology

authors： Ortiz JL,Cortijo J,Morcillo EJ,Sanz C,Perpiñá M,Esplugues J

更新日期：1988-12-13 00:00:00

abstract：:The release of endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) was investigated in synaptosomes prepared from various regions of the rat brain. The basal release of Asp, Glu and GABA from various regions was 12-35, 24-107 and 15-43 pmol/min per mg protein, respectively. Exposure ...

journal_title：European journal of pharmacology

authors： Kamisaki Y,Hamahashi T,Hamada T,Maeda K,Itoh T

更新日期：1992-06-24 00:00:00

abstract：:The effects of a 1,5-benzothiazepine derivative, (+)-cis-3-(acetyloxy)-5-[2-[[2-(3,4-dimethoxyphenyl)ethyl]-methyla mino]ethyl]-2,3-dihydro-2-(4-methyoxyphenyl)-1,5-benzothiazepine-4 (5H)-one (DTZ323), on membrane currents were investigated in guinea-pig ventricular myocytes using the whole-cell patch-clamp technique....

journal_title：European journal of pharmacology

authors： Kurokawa J,Adachi-Akahane S,Nagao T

更新日期：1997-05-01 00:00:00

abstract：:The intracerebroventricular injection of neosurugatoxin (2 x 3.2 micrograms) significantly reduced the specific binding of [3H]nicotine but not of [3H]cismethyldioxolane in the cerebral cortex, hippocampus and thalamus of rats 3 days after the toxin injection. Scatchard analysis of [3H]nicotine binding in the rat cere...

journal_title：European journal of pharmacology

authors： Yamada S,Ushijima H,Nakayama K,Hayashi E,Tsuji K,Kosuge T

更新日期：1988-11-01 00:00:00

abstract：:There is a large body of evidence to suggest that the sympathetic nervous system plays a critical role in the development of hypertension and vascular medial hypertrophy in the spontaneously hypertensive rat (SHR). The synthesis of a water soluble, specific alpha 1-adrenoceptor antagonist (terazosin) has permitted an ...

journal_title：European journal of pharmacology

authors： Jonsson JR,Head RJ,Frewin DB

更新日期：1992-02-11 00:00:00

abstract：:The influence of endothelin-1 on nociception induced by capsaicin was assessed in the mouse hindpaw. Local endothelin-1 injection (1 to 20 pmol/paw) 30 min prior to ipsilateral injection of capsaicin (0.1 microg/paw) increased, in a graded fashion, the time spent licking the injected paw. Maximal hyperalgesia was obta...

journal_title：European journal of pharmacology

authors： Piovezan AP,D'Orléans-Juste P,Tonussi CR,Rae GA

更新日期：1998-06-12 00:00:00

abstract：:The origin of the thrombocytopenia and leucopenia induced by protamine-heparin complexes is unknown. We studied the biochemical and cellular effects of protamine (6 mg x kg-1, i.v.) injected after heparin (5 mg x kg-1, i.v.) in New Zealand rabbits. After protamine injection (0.5 min) increases in blood platelet-activa...

journal_title：European journal of pharmacology

authors： Aïssa J,Nathan N,Arnoux B,Benveniste J

更新日期：1996-04-29 00:00:00

abstract：:In cases of severe human scorpion envenoming, lung injury is a common finding and frequently the cause of death. In the rat, two distinct mechanisms account for oedema following the intravenous injection of the venom -- acute left ventricular failure resulting from a massive release of catecholamines and an increase i...

journal_title：European journal of pharmacology

authors： Matos IM,Souza DG,Seabra DG,Freire-Maia L,Teixeira MM

更新日期：1999-07-09 00:00:00

abstract：:The tension in isolated ring preparations of the thoracic aorta from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was measured isometrically to study if there are any differences in the mechanisms of 17beta-estradiol- or progesterone-induced relaxation between WKY and SHR aortic rings. 17beta-Estr...

journal_title：European journal of pharmacology

authors： Unemoto T,Honda H,Kogo H

更新日期：2003-07-04 00:00:00