Abstract:
:Toluene diisocyanate (TDI)-induced asthma is a frequent occupational airway disease. To determine whether a calibrated dosage of oral slow-release theophylline inhibits asthmatic reactions and the associated increase of airway responsiveness to methacholine induced by TDI, we examined six asthmatic subjects who developed a late or a dual asthmatic reaction after TDI inhalation challenge. We administered oral slow-release theophylline or placebo to each subject for 7 days according to a double-blind, randomized, cross-over study design. When the subjects received a placebo, TDI caused a late or a dual asthmatic reaction. When the subjects received theophylline. TDI caused significantly reduced late asthmatic reactions. Mean serum theophylline concentrations were within the therapeutic range. Theophylline neither modified the baseline airway responsiveness to methacholine, nor the increase of airway responsiveness to methacholine induced by TDI. These results suggest that slow-release theophylline may improve TDI-induced late asthmatic reactions, but it does not change the baseline airway responsiveness to methacholine and the increase of airway responsiveness to methacholine induced by TDI.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Crescioli S,De Marzo N,Boschetto P,Spinazzi A,Plebani M,Mapp CE,Fabbri LM,Ciaccia Adoi
10.1016/0926-6917(92)90010-akeywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
45-50issue
1eissn
0014-2999issn
1879-0712journal_volume
228pub_type
临床试验,杂志文章,随机对照试验abstract::It has been reported that the antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) may result from the modulation of brain monoaminergic systems. However, the mechanisms of FDPI action are not fully understood. The aim of this study was to investigate the contribution of N-methyl-d-aspartate ...
journal_title:European journal of pharmacology
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journal_title:European journal of pharmacology
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