Abstract:
:3H-Glycine was released by 50 mM K+ in a calcium-dependent manner from rat substantia nigra slices. This release was abolished by GABA (0.1-1 mM) and muscimol (0.1 mM). Taurine and beta-alanine were without effect on evoked 3H-glycine release. The effect of GABA (0.5 mM) was reversed picrotoxin (50 micro M). These results support the hypothesis that GABA receptors may be present on glycinergic interneurones in the substantia nigra.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Kerwin R,Pycock Cdoi
10.1016/0014-2999(80)90041-2subject
Has Abstractpub_date
1980-06-13 00:00:00pages
169-72issue
2-3eissn
0014-2999issn
1879-0712pii
0014-2999(80)90041-2journal_volume
64pub_type
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