Abstract：
:Activated microglia that produce reactive nitrogen species (RNS), inflammatory factors, reactive oxygen species (ROS), and other neurovirulent factors may lead to the development of neurodegenerative diseases. Certain compounds can inhibit the activation of microglia. However, these mechanisms remain unclear. In the present study, we investigated the inhibitory effect of Gamma-decanolactone (GD) on the production of reactive oxygen species and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS) - stimulated N9 murine microglial cells through the p38 MAPK signaling pathway. The results showed that GD attenuated the activation of N9 cells and inhibited intracellular reactive oxygen species and the expression of iNOS and TNF-α induced by LPS in the cells. In addition, GD blocked the phosphorylation of p38 and inhibited cleaved caspase-9 and DNA damage. These data indicate that GD has therapeutic potential for the treatment of neurodegenerative diseases, and that it exerts its effects by inhibiting inflammation.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Pflüger P,Viau CM,Coelho VR,Berwig NA,Staub RB,Pereira P,Saffi Jdoi
10.1016/j.ejphar.2016.03.029subject
Has Abstractpub_date
2016-06-05 00:00:00pages
38-45eissn
0014-2999issn
1879-0712pii
S0014-2999(16)30149-2journal_volume
780pub_type
杂志文章abstract：:Parkinson's disease (PD) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the development of therapies that can stop or reverse the disease progression, identification of dependable biomarkers, and better understanding of the pathoph...
journal_title：European journal of pharmacology
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：European journal of pharmacology
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pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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abstract：:The purpose of this study was to elucidate the role of human organic anion transporters (human OATs) in the induction of drug-induced skeletal muscle abnormalities. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have been clinically used for lowering plasma cholesterol levels, and are known to in...
journal_title：European journal of pharmacology
pub_type： 杂志文章
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