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125I-endothelin-1 binding to brain and cardiac membranes from normotensive and spontaneously hypertensive rats.

Abstract：

:125I-labelled endothelin-1 was used to identify specific high affinity endothelin-1 binding sites in left ventricular and brain membranes harvested from female age-matched normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Relative to results obtained for brain membranes from normotensive rats, brain membranes from hypertensive rats exhibited an increase in 125I-endothelin-1 binding site density (P less than 0.02). In left ventricular membranes from the hypertensive rats 125I-endothelin-1 binding site density was reduced (P less than 0.02), relative to the density in ventricular membranes of normotensive rats. These results indicate that hypertension may have an organ specific effect on 125I-endothelin-1 binding site density.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Gu XH,Casley DJ,Cincotta M,Nayler WG

doi

10.1016/0014-2999(90)90272-8

subject

Has Abstract

pub_date

1990-02-27 00:00:00

pages

205-9

issue

3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(90)90272-8

journal_volume

177

pub_type

杂志文章

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