Picrotoxin changes the effects of imipramine and desipramine in rats in the forced swimming test.

abstract：:The effects of Ca2+ channel antagonists on the capsaicin-induced cough reflex in guinea pigs were studied. Intraperitoneal injection of nifedipine, verapamil and flunarizine in doses that ranged from 0.3 to 3.0 mg/kg decreased the number of coughs in a dose-dependent manner. These Ca2+ channel antagonists exhibited an...

journal_title：European journal of pharmacology

authors： Kamei J,Kasuya Y

更新日期：1992-02-25 00:00:00

abstract：:Emodin, an anthraquinone derivative isolated from root and rhizome of Rheum palmatum, has been reported to have promising anti-diabetic activity. The present study was to explore the possible mechanism of emodin to ameliorate insulin resistance. Insulin resistance was induced by feeding a high fat diet to Sprague-Dawl...

journal_title：European journal of pharmacology

authors： Cao Y,Chang S,Dong J,Zhu S,Zheng X,Li J,Long R,Zhou Y,Cui J,Zhang Y

更新日期：2016-06-05 00:00:00

abstract：:It has been reported that the antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI) may result from the modulation of brain monoaminergic systems. However, the mechanisms of FDPI action are not fully understood. The aim of this study was to investigate the contribution of N-methyl-d-aspartate ...

journal_title：European journal of pharmacology

authors： Pesarico AP,Stangherlin EC,Rosa SG,Mantovani AC,Zeni G,Nogueira CW

更新日期：2016-07-05 00:00:00

abstract：:Selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N- (methylsulfonyl)acetamide]) is a novel, orally available non-prostanoid prostacyclin receptor (IP receptor) agonist that has recently been approved for the treatment of pulmonary arterial hypertension (PAH). We examined the effect of the a...

journal_title：European journal of pharmacology

authors： Fuchikami C,Murakami K,Tajima K,Homan J,Kosugi K,Kuramoto K,Oka M,Kuwano K

更新日期：2017-01-15 00:00:00

abstract：:4,6,6-Trimethylcaprolactam antagonised GABAA receptor-mediated contractile responses in guinea-pig isolated ileum, displacing the GABA dose-response curve to the right in a non-parallel manner, and causing a depression of the maximum response. Pentobarbitone not only potentiated the GABAA receptor-mediated contraction...

journal_title：European journal of pharmacology

authors： Kerr DI,Ong J,Prager RH,Ward DA

更新日期：1986-05-13 00:00:00

abstract：:The effect of nimodipine was studied on EEG power density spectra as well as on 31P-NMR spectra of the brain before, during and after four-vessel occlusion (FVO) in the restrained conscious rat. EEG-spectral analysis: eight rats were submitted to 5 min FVO and four of them received nimodipine (1 mg/kg orally) 75 min b...

journal_title：European journal of pharmacology

authors： Deutz NE,Chamuleau RA,Bovée WM,Van der Werf AJ

更新日期：1986-06-24 00:00:00

abstract：:COVID-19 pandemic presents an unprecedented challenge to identify effective drugs for treatment. Despite multiple clinical trials using different agents, there is still a lack of specific treatment for COVID-19. Having the potential role in suppressing inflammation, immune modulation, antiviral and improving respirato...

journal_title：European journal of pharmacology

authors： Monji F,Al-Mahmood Siddiquee A,Hashemian F

更新日期：2020-11-15 00:00:00

abstract：:The effect of noradrenaline on 5-hydroxytryptamine (5-HT) release from isolated mouse ileal tissues was investigated. Noradrenaline, but not isoprenaline, at 1 microM stimulated 5-HT release, an effect which was inhibited by yohimbine, an alpha(2)-adrenoceptor antagonist, but not by bunazosin, an alpha(1)-adrenoceptor...

journal_title：European journal of pharmacology

authors： Hirafuji M,Ogawa T,Kato K,Hamaue N,Endo T,Parvez H,Minami M

更新日期：2001-12-07 00:00:00

abstract：:Food intake is regulated by various factors such as neuropeptide Y. Neuropeptide Y potently induces an increase in food intake, and simultaneously stimulates arginine-vasopressin (AVP) secretion in the brain. Recently, we reported that V(1A) vasopressin receptor-deficient (V(1A)R(-/-)) mice exhibited altered daily foo...

journal_title：European journal of pharmacology

authors： Aoyagi T,Kusakawa S,Sanbe A,Hiroyama M,Fujiwara Y,Yamauchi J,Tanoue A

更新日期：2009-11-10 00:00:00

abstract：:This study addressed the possibility that acetylcholine-induced relaxation in the rabbit aorta is mediated by dual mechanisms: one N omega-nitro-L-arginine (NLA)-sensitive, the other glybenclamide-sensitive. Acetylcholine, nitroglycerin and BRL38227 (lemakalim), an activator of glybenclamide-sensitive potassium channe...

journal_title：European journal of pharmacology

authors： Bellan JA,Longenecker LL,Kadowitz PJ,McNamara DB

更新日期：1993-04-06 00:00:00

abstract：:Two highly selective mu-opioid receptor agonists, endomorphin-1 and endomorphin-2, have been identified and postulated to be endogenous ligands for mu-opioid receptors. Intrathecal (i.t.) administration of endomorphin-1 and endomorphin-2 at doses from 0.039 to 5 nmol dose-dependently produced antinociception with the ...

journal_title：European journal of pharmacology

authors： Sakurada S,Hayashi T,Yuhki M,Orito T,Zadina JE,Kastin AJ,Fujimura T,Murayama K,Sakurada C,Sakurada T,Narita M,Suzuki T,Tan-no K,Tseng LF

更新日期：2001-09-21 00:00:00

abstract：:The coronary vasoconstrictor effect of endothelin-1 was characterized in the isolated rat heart by using the endothelin ETA receptor antagonist D-Asp-L-Pro-D-Val-L-Leu-D-Trp (BQ-123) and the endothelin ETB receptor antagonist [Cys11-Cys15]endothelin-1-(11-21) (IRL 1038). In addition, the involvement of nitric oxide an...

journal_title：European journal of pharmacology

authors： Wang QD,Li XS,Pernow J

更新日期：1994-12-12 00:00:00

abstract：:Cats, sedated and paralyzed, showed a significant increase in body temperature after intravenous injection of morphine while animals with additional spinal blockade (C3) from injection of 2% lidocaine solution, did not. The results suggest that motor activity is not necessary for morphine-induced hyperthermia in the c...

journal_title：European journal of pharmacology

authors： Wallenstein MC

更新日期：1978-06-01 00:00:00

abstract：:The aim of this study was to elucidate the possible mechanism of the potentiating action of metal ions (Cu2+, Hg2+, Ag+ and SeO3(2-)) on the ryanodine-induced contracture of the mouse diaphragm. The ryanodine contracture in the quiescent muscle could be augmented by either electrical stimulation or pretreatment with h...

journal_title：European journal of pharmacology

authors： Liu SH,Lin-Shiau SY

更新日期：1994-01-04 00:00:00

abstract：:Family, adoption and twin studies have highlighted the significant role of heritable influences on individual differences in opioid addiction. Meanwhile, obsessive-compulsive disorder (OCD) is a disorder wherein the individual experiences recurring thoughts that cause irrational fears and anxiety. In the present study...

journal_title：European journal of pharmacology

authors： Rohbani K,Sabzevari S,Sadat-Shirazi MS,Nouri Zadeh-Tehrani S,Ashabi G,Khalifeh S,Ale-Ebrahim M,Zarrindast MR

更新日期：2019-12-15 00:00:00

abstract：:The beta-amyloid peptide-(25-35) fragment, but not beta-amyloid peptide-(1-28), shares with beta-amyloid protein-(1-42) the ability to self-aggregate and to induce neurotoxicity in vitro. This study examined the induction of amnesia in rats given intracerebroventricularly soluble or aggregated beta-amyloid peptide-(25...

journal_title：European journal of pharmacology

authors： Delobette S,Privat A,Maurice T

更新日期：1997-01-14 00:00:00

abstract：:In animals and man the antidysrhythmic agent disopyramide in primarily metabolised by mono-N-dealkylation. The effects of disopyramide and its N-dealkylated metabolite (MIP) have been investigated using isolated cardiac and nervous tissue, and their effects have been compared with the effects of other antidysrhythmic ...

journal_title：European journal of pharmacology

authors： Grant AM,Marshall RJ,Ankier SI

更新日期：1978-06-15 00:00:00

abstract：:Long-term treatment with sodium barbital did not alter significantly the responsiveness of the isolated rat vas deferens to noradrenaline. However, three days after barbital withdrawal there was a 4.5-fold increase in the sensitivity and an enhanced maximum response to the neurotransmitter. Pharmacological analysis of...

journal_title：European journal of pharmacology

authors： Saban R,Capaz FR,De Moraes S

更新日期：1982-08-13 00:00:00

abstract：:In previous studies, we have shown that opioid agonists ([D-Ala2, D-Leu5]enkephalin (DADLE), [D-Ser2, Leu5]enkephalin-Thr6 (DSLET), ethylketocyclazocine and etorphine) bind to opioid binding sites and decrease cell proliferation of human T47D breast cancer cells. Furthermore, we provided evidence about a cross-reactio...

journal_title：European journal of pharmacology

authors： Hatzoglou A,Bakogeorgou E,Hatzoglou C,Martin PM,Castanas E

更新日期：1996-08-29 00:00:00

abstract：:The effect of ouabain (10(-3) M) on contractile responses of SHR (spontaneously hypertensive rat) and WKY (Wistar-Kyoto rat) aortas and mesenteric arteries was studied. Ouabain addition caused a rapid contraction of aortic strips with a steeper rate of rise and a larger maximal force development in strips from SHR tha...

journal_title：European journal of pharmacology

authors： Morita S,Iwasaki T,Nagai K,Miyata S,Kawai Y

更新日期：1988-07-14 00:00:00

abstract：:Little research has been conducted investigating the long-term impact of opioid exposure during adolescence. These experiments were conducted to determine the behavioral effects of morphine exposure during periadolescence (postnatal days 30-32) versus young adulthood (postnatal days 65-67) on subsequent sensitivity to...

journal_title：European journal of pharmacology

authors： White DA,Holtzman SG

更新日期：2005-12-28 00:00:00

abstract：:Diabetes mellitus is associated with a decrease in bone quality and an increase in fracture incidence. Additionally, treatment with anti-diabetic drugs can either adversely or positively affect bone metabolism. In this study we evaluated: the effect of a 3-week oral treatment with saxagliptin on femoral microarchitect...

journal_title：European journal of pharmacology

authors： Sbaraglini ML,Molinuevo MS,Sedlinsky C,Schurman L,McCarthy AD

更新日期：2014-03-15 00:00:00

abstract：:This study sought to determine the potential role of nitric oxide (NO) in N-methyl-D-aspartate (NMDA)-stimulated efflux of [14C] gamma-aminobutyric acid (GABA) and [3H]acetylcholine from striatal slices in vitro. In Mg2+-free buffer, NMDA-stimulated [14C]GABA and [3H]acetylcholine release were inhibited by the guanyla...

journal_title：European journal of pharmacology

authors： Hanania T,Johnson KM

更新日期：1998-10-23 00:00:00

abstract：:Dysfunction of the innate immune system has been reported to cause intestinal inflammation. Vitamin D3 is known to be an important immune system regulator and exerts anti-inflammatory effects. We investigated in vitro effects of vitamin D3 and its derivatives on the innate immune system in HT-29 cells, a line of human...

journal_title：European journal of pharmacology

authors： Hidaka M,Wakabayashi I,Takeda Y,Fukuzawa K

更新日期：2013-12-05 00:00:00

abstract：:This study examined whether a clinically relevant concentration of the volatile anaesthetic halothane modifies the endothelium-dependent relaxation produced by acetylcholine (3 nM-10 microM), histamine (1 pM-0.1 microM) and anti-human immunoglobulin E (1:1000) in human isolated pulmonary arteries submaximally precontr...

journal_title：European journal of pharmacology

authors： Higueras J,Sarría B,Ortiz JL,Cortijo J,Maruenda A,Barberá M,Morcillo EJ

更新日期：1997-05-20 00:00:00

abstract：:Alzheimer's disease, an age-related neurodegenerative disorder, is characterized clinically by a progressive loss of memory and cognitive functions. Neuropathologically, Alzheimer's disease is defined by the accumulation of extracellular amyloid protein deposited senile plaques and intracellular neurofibrillary tangle...

journal_title：European journal of pharmacology

authors： Butterfield DA,Perluigi M,Sultana R

更新日期：2006-09-01 00:00:00

abstract：:The action of (+)-S-12967 and (-)-S-12968, two isomers of a new 1,4-dihydropyridine molecule (2-(-7-amino-2,5-dioxaheptyl)-3-ethoxycarbonyl-4-(2,3-dichlorop hen yl)-5-methoxycarbonyl-6-methyl 1,4-dihydropyridine), was studied on responses of rat isolated coronary resistance arteries (i.d. about 230 microns) to K+, Ca...

journal_title：European journal of pharmacology

authors： Prieto D,Mulvany MJ,Nyborg NC

更新日期：1993-07-06 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is one of the major cardiac complications in diabetic patients and a major reason for the death of diabetic patients. Obeticholic acid (OCA) is a semi-synthetic bile acid analogue. The objective of the present study was to investigate the possible cardio-protective effect of OCA against D...

journal_title：European journal of pharmacology

authors： Wu H,Liu G,He Y,Da J,Xie B

更新日期：2019-09-05 00:00:00

abstract：:The effects of a thrombin active-site inhibitor on arterial and venous thrombosis, and thrombin-induced thrombocytopenia were determined in anesthetized rats. Desamino D-Phe-Pro-Arg-aldehyde (BMY 44621) was administered before experimental intervention as a loading i.v. dose plus continuous i.v. infusion. Carotid arte...

journal_title：European journal of pharmacology

authors： Schumacher WA,Balasubramanian N,St Laurent DR,Seiler SM

更新日期：1994-07-01 00:00:00

abstract：:The molecular mechanism underlying the activity of the novel antiepileptic drug retigabine is not yet fully understood. The aim of this study was to investigate whether retigabine interacts directly with the GABA(A) receptor complex (gamma-aminobutyric acid). Receptor-binding assays were conducted using rat brain memb...

journal_title：European journal of pharmacology

authors： van Rijn CM,Willems-van Bree E

更新日期：2003-03-19 00:00:00