Effects of nimodipine on EEG and 31P-NMR spectra during and after incomplete forebrain ischemia in the rat.

abstract：:d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions prod...

journal_title：European journal of pharmacology

authors： Zhang L,Dyer DC

更新日期：1993-01-05 00:00:00

abstract：:The putative imidazoline I(3) receptor antagonist 2-(2-ethyl-2,3-dihydrobenzo[b]furan-2-yl)-1H-imidazole (KU14R) has been shown to block the effects of the atypical I(3) agonist efaroxan at the level of the ATP-sensitive K(+) (K(ATP)) channel in isolated pancreatic islet beta cells, but its effects in vivo are not kno...

journal_title：European journal of pharmacology

authors： Mayer G,Taberner PV

更新日期：2002-11-01 00:00:00

abstract：:The effect of an antisense oligonucleotide to the K+ channel coding mKv1.1 mRNA on antinociception induced by the tricyclic antidepressants, clomipramine (20-35 mg kg(-1) s.c.) and amitriptyline (10-25 mg kg(-1) s.c.), was investigated in the mouse hot-plate test. Antisense oligonucleotide (0.5-1.0-2.0-3.0 nmol per i....

journal_title：European journal of pharmacology

authors： Galeotti N,Ghelardini C,Capaccioli S,Quattrone A,Nicolin A,Bartolini A

更新日期：1997-07-02 00:00:00

abstract：:The mechanisms of ryanodine-induced contractions were studied in strips of femoral arteries from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Ryanodine (30 nM to 30 microM) alone contracted arterial strips in a dose-dependent manner. The maximum contraction in SHR was about 5 times g...

journal_title：European journal of pharmacology

authors： Kojima M,Dohi Y,Sato K

更新日期：1994-03-11 00:00:00

abstract：:In chloralose-anaesthesized cats, clonidine, an alpha 2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole alpha 2-adrenoceptor agonist, and was reversed by SK & F 864...

journal_title：European journal of pharmacology

authors： Downie JW,Espey MJ,Gajewski JB

更新日期：1991-03-26 00:00:00

abstract：:Leukotriene C4 binding to mouse brain membranes was readily displaced by S-alkylglutathione derivatives, with the affinity of the test compound increasing as the alkyl chain length increases. S-decylglutathione was as potent as leukotriene C4. These data suggest that brain membrane leukotriene C4 binding sites are S-a...

journal_title：European journal of pharmacology

authors： Goffinet AM,Nguyen A

更新日期：1989-02-14 00:00:00

abstract：:The quantitative [14C]2-deoxyglucose autoradiographic technique was applied to the measurement of the cerebral metabolic effects of adenosine A1 and A2 receptor agonists and antagonists in adult rats. The adenosine A1 receptor agonist and antagonist, 2-chloro-N6-cyclopentyladenosine (CCPA) and 8-cyclopentyl-1,3-diprop...

journal_title：European journal of pharmacology

authors： Nehlig A,Daval JL,Boyet S

更新日期：1994-06-02 00:00:00

abstract：:Prior studies demonstrated that guanabenz reduces systemic blood pressure by inhibiting central sympathetic outflow as well as by adrenergic neuron blockade. Potential mechanisms responsible for the reduction of efferent sympathetic activity were examined in the present series. Guanabenz failed to modify carotid sinus...

journal_title：European journal of pharmacology

authors： Baum T,Shropshire AT

更新日期：1976-05-01 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is one of the major cardiac complications in diabetic patients and a major reason for the death of diabetic patients. Obeticholic acid (OCA) is a semi-synthetic bile acid analogue. The objective of the present study was to investigate the possible cardio-protective effect of OCA against D...

journal_title：European journal of pharmacology

authors： Wu H,Liu G,He Y,Da J,Xie B

更新日期：2019-09-05 00:00:00

abstract：:Drugs of abuse and stress are associated with changes in circulating cell populations and reductions in cell-mediated immune responses. The main goal of this study was to determine the influence of repeated and acute d-amphetamine treatments on the foot-shock stress-induced effects on the peripheral lymphocyte subpopu...

journal_title：European journal of pharmacology

authors： Assis MA,Pacchioni AM,Collino C,Paz MC,Sotomayor C,Basso AM,Cancela LM

更新日期：2008-04-28 00:00:00

abstract：:The activation of eosinophils with the lipid mediator, leukotriene B(4), induces their homotypic aggregation. Upon activation with leukotriene B(4), eosinophils release a significant amount of arachidonic acid, a process dependent on the activation of phospholipase A(2). Here, we have evaluated whether arachidonic aci...

journal_title：European journal of pharmacology

authors： Teixeira MM,Lindsay MA,Giembycz MA,Hellewell PG

更新日期：1999-11-19 00:00:00

abstract：:Incubated tissue slices from different regions of the rat brain contained cyclic guanosine 3',5'-monophosphate (cyclic GMP) in the following descending order of content: cerebellum greater than hypothalamus greater than striatum greater than thalamusmidbrain greater than brain stem greater that hippocampus greater tha...

journal_title：European journal of pharmacology

authors： Palmer GC,Duszynski CR

更新日期：1975-06-01 00:00:00

abstract：:Heme oxygenase is the rate-limiting enzyme in the catabolism of heme to carbon monoxide, bilirubin and free iron. Many cell types express heme oxygenase-2 constitutively while heme oxygenase-1 is induced at sites of inflammation and oxidative stress. In systemic blood vessels, carbon monoxide may have an important hom...

journal_title：European journal of pharmacology

authors： Stanford SJ,Walters MJ,Hislop AA,Haworth SG,Evans TW,Mann BE,Motterlini R,Mitchell JA

更新日期：2003-07-25 00:00:00

abstract：:The effects of intra- and extraluminal capsaicin administration were evaluated in isolated perfused rat mesenteric bed. Capsaicin (10 nM-1 microM) produced a potent concentration-dependent relaxation of the tonic vasoconstriction induced by norepinephrine (1 microM) but not by high-K+ (60 mM). The capsaicin-induced re...

journal_title：European journal of pharmacology

authors： Manzini S,Perretti F

更新日期：1988-03-29 00:00:00

abstract：:KF17837 is a novel selective adenosine A2A receptor antagonist. Oral administration of KF17837 (2.5, 10.0 and 30.0 mg/kg) significantly ameliorated the cataleptic responses induced by intracerebroventricular administration of an adenosine A2A receptor agonist, CGS 21680 (10 micrograms), in a dose-dependent manner. KF1...

journal_title：European journal of pharmacology

authors： Kanda T,Shiozaki S,Shimada J,Suzuki F,Nakamura J

更新日期：1994-05-02 00:00:00

abstract：:The aim was to determine whether blockade of store-operated Ca(2+) entry, or inhibition of Ca(2+) sensitisation, is the predominant mechanism by which neuronally released nitric oxide mediates relaxation of the mouse anococcygeus. Nitrergic relaxations to field stimulation (10 Hz, 10 s trains) were unaffected by the s...

journal_title：European journal of pharmacology

authors： Gibson A,Wallace P,McFadzean I

更新日期：2003-06-27 00:00:00

abstract：:We investigated the mechanism of antithrombin III-induced vascular release of endothelins in rat isolated lung. The antithrombin III-stimulated release of big endothelin-1 and endothelin-1 (1.7-fold and 1.3-fold over baseline) was abolished by nicardipine (L-type Ca2+ channel blocker), heparin, and N-acetyl heparin (a...

journal_title：European journal of pharmacology

authors： Stangl K,Dschietzig T,Alexiou K,Brunner F

更新日期：1999-04-01 00:00:00

abstract：:Effects of the alpha2-adrenoceptor antagonist yohimbine on the antinociception produced by a low dose of naloxone were examined in a rat model of carrageenan-induced inflammation. In rats receiving saline prior to naloxone injection, the low dose of naloxone (5 microg/kg, i.p.) significantly prolonged paw withdrawal l...

journal_title：European journal of pharmacology

authors： Tsuruoka M,Hiruma Y,Matsutani K,Matsui Y

更新日期：1998-05-08 00:00:00

abstract：:The present study investigated the effect of morphine sensitization on the impairment of spatial memory retrieval induced by acute morphine in adult male rats. Spatial memory was assessed by 2-day Morris water maze task which included training and test day. On the training day, rats were trained by a single training s...

journal_title：European journal of pharmacology

authors： Farahmandfar M,Naghdi N,Karimian SM,Kadivar M,Zarrindast MR

更新日期：2012-05-15 00:00:00

abstract：:We investigated protein kinase C participation in the contractile response to 5-hydroxytryptamine (5-HT), and in the interaction between 5-HT and endothelin-1, in aortas from control and diabetic rats. Diabetic rats display attenuated reactivity to 5-HT (i.e., approximately 47% of control maximum). The protein kinase ...

journal_title：European journal of pharmacology

authors： James GM,Hodgson WC

更新日期：1997-03-12 00:00:00

abstract：:The ability of the kappa-opioid receptor agonist U69593 to attenuate the sensitization and cross-sensitization which develops to the conditioned rewarding effects of morphine and cocaine was examined using an unbiased place-preference conditioning procedure. The influence of U69593 treatment upon sensitization and cro...

journal_title：European journal of pharmacology

authors： Shippenberg TS,LeFevour A,Thompson AC

更新日期：1998-03-12 00:00:00

abstract：:The ability of calcium entry blockers to inhibit allergic histamine release from rabbit leukocytes was studied. Bepridil, verapamil, nifedipine, diltiazem and TMB-8 produced concentration-dependent inhibition of allergic histamine release from rabbit leukocytes. The calculated IC50s (microM) were as follows: verapamil...

journal_title：European journal of pharmacology

authors： Chand N,Pillar J,Diamantis W,Sofia RD

更新日期：1985-01-08 00:00:00

abstract：:This study shows that in spontaneously hypertensive rats (SHR) of 14-weeks-old, the sympathetically-induced, but not noradrenaline-induced tachycardic response are higher than age-matched Wistar normotensive rats. Furthermore, in SHR the sympathetically-induced tachycardic response was: (1) unaffected by moxonidine (3...

journal_title：European journal of pharmacology

authors： Cobos-Puc LE,Sánchez-López A,Centurión D

更新日期：2016-11-15 00:00:00

abstract：:The ability of flunarizine to terminate ouabain-induced ventricular tachycardia was investigated in conscious dogs. These arrhythmias result from triggered activity based on delayed afterdepolarizations. Sustained ventricular tachycardia was induced by ouabain (48 +/- 6 micrograms/kg) and pacing in 13 animals with sur...

journal_title：European journal of pharmacology

authors： Vos MA,Gorgels AP,Drenth JP,Leunissen JD,Wellens HJ

更新日期：1989-06-08 00:00:00

abstract：:Inhibition of local cortisol regeneration from circulating cortisone by blocking 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been shown to ameliorate the risk factors associated with the metabolic syndrome. Chronic modulation of glucocorticoid homeostasis may result in hypothalamic-pituitary-adrenal (HPA) axis s...

journal_title：European journal of pharmacology

authors： Hamilton BS,Schoelch C,Schuler-Metz A,Krosky P,Lala DS,Claremon DA,McGeehan GM

更新日期：2016-10-15 00:00:00

abstract：:In the present study we investigated the in vivo pharmacological profile of the benz[e]indole cis-8-hydroxy-3-(n-propyl)],2,3a,4,5,9b-hexahydro-1H-benz[e]indole (cis-8-OH-PBZI), which has been described as a preferential dopamine D3 receptor agonist in vitro. The compound inhibited spontaneous locomotor activity in mi...

journal_title：European journal of pharmacology

authors： Fink-Jensen A,Nielsen EB,Hansen L,Scheideler MA

更新日期：1998-01-26 00:00:00

abstract：:The effects of nicotine, carbachol, hexamethonium and scopolamine were investigated on distress vocalizations (DBs) of acutely isolated domestic chicks. Nicotine attenuated, while the antimuscarinic scopolamine increased the frequency of separation-induced DVs. Furthermore, the stress attenuating effects of nicotine w...

journal_title：European journal of pharmacology

authors： Sahley TL,Panksepp J,Zolovick AJ

更新日期：1981-06-19 00:00:00

abstract：:Recent studies in this laboratory have demonstrated the ability of acetylcholine receptor agonists to produce systemic arterial pressor responses through stimulation of spinal muscarinic receptors. In urethane-anesthetized rats a new surgical procedure was employed to permit microinjection of drugs into the cerebrospi...

journal_title：European journal of pharmacology

authors： Feldman DS,Buccafusco JJ

更新日期：1993-12-21 00:00:00

abstract：:Accumulating evidence indicates protective actions of mineralocorticoid antagonists (MR antagonists) on cardiovascular pathology, which includes blunting vascular inflammation and myocardial fibrosis. We examined the anti-inflammatory and anti-fibrotic potential of MR antagonists in rodent respiratory models. In an ov...

journal_title：European journal of pharmacology

authors： Lieber GB,Fernandez X,Mingo GG,Jia Y,Caniga M,Gil MA,Keshwani S,Woodhouse JD,Cicmil M,Moy LY,Kelly N,Jimenez J,Crawley Y,Anthes JC,Klappenbach J,Ma YL,McLeod RL

更新日期：2013-10-15 00:00:00

abstract：:It is widely believed that metabotropic glutamate (mGlu) receptors play a potential role in memory formation. However, the particular function of different classes of mGluRs, or even subtypes, remains elusive. We show here that intraperitoneal injection of the class I selective antagonist 1-aminoindan-1,5-dicarboxylic...

journal_title：European journal of pharmacology

authors： Nielsen KS,Macphail EM,Riedel G

更新日期：1997-05-20 00:00:00