Brain leukotriene C4 binding sites are S-alkylglutathione binding sites.

abstract：:The influence of native low-density lipoprotein (LDL) on the inhibition of endothelium-dependent relaxation previously induced by oxidized LDL was investigated with intact rabbit aortic rings. We also tried to assess oxysterol involvement in the native lipoprotein effects. Lipoprotein fractions (1 mg protein/ml) were ...

journal_title：European journal of pharmacology

authors： Perségol L,Sementa V,Athias A,Lecerf J,Lallemant C,Gambert P

更新日期：2000-10-20 00:00:00

abstract：:Many central stimulating drugs have a pronounced stimulatory effect on striatal and cortical activity which is associated to enhanced function of mesencephalic dopaminergic neurons. Mesencephalic KCNQ (also termed K(v)7) potassium channels suppress the basal activity of dopaminergic neurons in the substantia nigra and...

journal_title：European journal of pharmacology

authors： Hansen HH,Andreasen JT,Weikop P,Mirza N,Scheel-Krüger J,Mikkelsen JD

更新日期：2007-09-10 00:00:00

abstract：:2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)bip hen yl-4-yl)methyl]imidazole, potassium salt (Losartan) (previous name, DuP 753 or MK 954) is a nonpeptide angiotensin II receptor antagonist. This study was performed to investigate the ability of Losartan to inhibit the angiotensin II-induced stimulatio...

journal_title：European journal of pharmacology

authors： Ko Y,Görg A,Appenheimer M,Wieczorek AJ,Düsing R,Vetter H,Sachinidis A

更新日期：1992-10-01 00:00:00

abstract：:In a medium containing 100 mM NaCl and 10 mM MgCl2, the binding of antagonists to rat myocardial muscarinic receptors is well described by the simple Langmuir isotherm. However, in low ionic strength media, while a small proportion of the sites (23%) display a small (2-3 fold) increase in antagonist affinity, the majo...

journal_title：European journal of pharmacology

authors： Hulme EC,Berrie CP,Birdsall NJ,Burgen AS

更新日期：1981-07-17 00:00:00

abstract：:In the Brattleboro rat with diabetes insipidus vasopressin V2 receptor mRNA and the mRNA of various adenylyl cyclase (AC) isoforms are moderately reduced compared with those of normal rats. In the present study renal vasopressin V2 receptor mRNA was modestly higher (by 34%), as was expression of AC 5, 6 and 9 mRNAs (u...

journal_title：European journal of pharmacology

authors： Shen T,Laycock J,Suzuki Y,Defer N,Hanoune J

更新日期：1998-01-02 00:00:00

abstract：:Multiple myeloma is an incurable hematological malignancy. Different studies demonstrated the occurrence of genetic and epigenetic alterations in multiple myeloma. Histone lysine methylation has emerged as a central epigenetic change in the organization of eukaryotic chromatin with far-reaching implications for the re...

journal_title：European journal of pharmacology

authors： Zhao F,Chen Y,Zeng L,Li R,Zeng R,Wen L,Liu Y,Zhang C

更新日期：2010-11-10 00:00:00

abstract：:Acute leukemia is a malignant clonal hematopoietic stem cell disease. In the current study, we examined the effects of bryostatin 5 on acute monocytic leukemia cells in vitro and in vivo. We also explored the mechanisms and pathways underlying the increase in apoptosis induced by bryostatin 5. Bryostatin 5 inhibited t...

journal_title：European journal of pharmacology

authors： Wang Y,Zhang J,Wang Q,Zhang T,Yang Y,Yi Y,Gao G,Dong H,Zhu H,Li Y,Lin H,Tang H,Chen X

更新日期：2013-10-15 00:00:00

abstract：:Rat pheochromocytoma PC12W cell membranes have previously been shown to exclusively contain the AT2 receptor subtype. The present study extended these binding data and explored the functional expression of these binding sites. Our binding competition studies show a potency series of Ang II = Ang III greater than saral...

journal_title：European journal of pharmacology

authors： Leung KH,Roscoe WA,Smith RD,Timmermans PB,Chiu AT

更新日期：1992-09-01 00:00:00

abstract：:Kisspeptin (KP), the endogenous ligand of GPR54, is a mammalian amidated neurohormone, which belongs to the RF-amide peptide family. However, in contrast with the related members of the RF-amide family, little information is available regarding its role in the gastrointestinal motility. With regard to the recent data ...

journal_title：European journal of pharmacology

authors： Jiang J,Jin W,Peng Y,He Z,Wei L,Li S,Wang X,Chang M,Wang R

更新日期：2017-01-05 00:00:00

abstract：:Autophagy is a lysosomal degradation pathway, which is essential for cell survival, proliferation, differentiation and homeostasis. It is well known that beta-amyloid (Aβ) aggregation is one of key characteristics for Alzheimer's disease (AD), which triggers a complex pathological cascade, leading to neurodegeneration...

journal_title：European journal of pharmacology

authors： Wang C,Zhang X,Teng Z,Zhang T,Li Y

更新日期：2014-10-05 00:00:00

abstract：:Cerebral ischemia impairs physiological form of synaptic plasticity such as long-term potentiation (LTP). Clinical symptoms of cognitive dysfunction resulting from cerebral ischemia are associated with neuron loss and synaptic function impairment in hippocampus. It has been widely reported that cordycepin displays neu...

journal_title：European journal of pharmacology

authors： Dong ZS,Cao ZP,Shang YJ,Liu QY,Wu BY,Liu WX,Li CH

更新日期：2019-06-15 00:00:00

abstract：:Intrastriatal injection of kainic acid (5 nmoles) to rats led to severe destruction of nerve cell bodies throughout the caudate-putamen complex and an extensive proliferation of glial cells. Lesioned striata displayed a significant 23% loss of beta-adrenoceptor binding sites 21--24 days after injection of kainic acid....

journal_title：European journal of pharmacology

authors： Nahorski SR,Howlett DR,Redgrave P

更新日期：1979-12-07 00:00:00

abstract：:The maximal pressor effect induced by DOI in the pithed rat was smaller than that induced by 5-HT, suggesting partial agonistic properties of DOI. DOI shifted the dose-pressor response curve of 5-HT to the right. It is concluded that, in addition to its 5-HT2 agonistic properties, DOI also possesses 5-HT2 antagonistic...

journal_title：European journal of pharmacology

authors： Dabiré H,Chaouche-Teyara K,Cherqui C,Fournier B,Schmitt H

更新日期：1989-10-24 00:00:00

abstract：:The present paper describes the effect of beta-phenylethylamine and its metabolites phenylethanolamine, tyramine, acetyl-phenylethylamine and phenylacetaldehyde on the dopaminergic nigrostriatal system. The rotational behavioural response to the i.v. injection of these drugs was quantified in animals with a unilateral...

journal_title：European journal of pharmacology

authors： Barroso N,Rodriguez M

更新日期：1996-02-22 00:00:00

abstract：:We have examined the pharmacology of kainate receptors in cultured hippocampal neurons (6-8 days in vitro (DIV)) from embryonic rats (E17). Cultured neurons were pre-treated with concanavalin A to remove kainate receptor desensitization and whole-cell voltage clamp electrophysiology employed to record inward currents ...

journal_title：European journal of pharmacology

authors： Bleakman D,Ogden AM,Ornstein PL,Hoo K

更新日期：1999-08-13 00:00:00

abstract：:Pain remains a major clinical challenge because there are no effective analgesics for some pain conditions and the mainstay analgesics for severe pain, opioids, have serious unwanted effects. There is a dire need for novel analgesics in the clinic. Imidazoline receptors are a family of three receptors (I(1), I(2) and ...

journal_title：European journal of pharmacology

authors： Li JX,Zhang Y

更新日期：2011-05-11 00:00:00

abstract：:Most virus infections induce cycloxygenase-2 (COX-2) expression and subsequent prostaglandin E(2) (PGE(2)) production in cells, an inflammatory response that might be detrimental to virus replication and pathogenesis. This response in dengue virus infection remains to be elucidated. Triptolide and tetrandrine, compoun...

journal_title：European journal of pharmacology

authors： Liou JT,Chen ZY,Ho LJ,Yang SP,Chang DM,Liang CC,Lai JH

更新日期：2008-07-28 00:00:00

abstract：:Huperzine A, a promising therapeutic agent for Alzheimer's disease, was examined for its potential to antagonize the deleterious neurochemical, structural, and cognitive effects of infusing beta-amyloid protein-(1-40) into the cerebral ventricles of rats. Daily intraperitoneal administration of huperzine A for 12 cons...

journal_title：European journal of pharmacology

authors： Wang R,Zhang HY,Tang XC

更新日期：2001-06-15 00:00:00

abstract：:In chloralose-anaesthesized cats, clonidine, an alpha 2-adrenoceptor agonist with an imidazole ring, depressed pudendal nerve reflex activity. Clonidine's inhibitory action on this compound action potential response was mimicked by guanabenz, a non-imidazole alpha 2-adrenoceptor agonist, and was reversed by SK & F 864...

journal_title：European journal of pharmacology

authors： Downie JW,Espey MJ,Gajewski JB

更新日期：1991-03-26 00:00:00

abstract：:The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM...

journal_title：European journal of pharmacology

authors： Fujita R,Tamazawa Y,Barnard EA,Matsumoto M

更新日期：1993-08-24 00:00:00

abstract：:This paper describes the pharmacological activity of D,L-(tetrazol-5-yl)glycine, a structurally novel and highly potent agonist at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. D,L-(Tetrazol-5-yl)glycine potently displaced NMDA receptor binding to rat brain membranes as measured using [3H]...

journal_title：European journal of pharmacology

authors： Schoepp DD,Smith CL,Lodge D,Millar JD,Leander JD,Sacaan AI,Lunn WH

更新日期：1991-10-15 00:00:00

abstract：:Berberine, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous medicinal plants and has an array of pharmacological properties. It has been used in Ayurvedic and Chinese medicine for its antimicrobial, antiprotozoal, antidiarrheal and antitrachoma activity. Moreover, several clinical and preclin...

journal_title：European journal of pharmacology

authors： Kumar A,Ekavali,Chopra K,Mukherjee M,Pottabathini R,Dhull DK

更新日期：2015-08-15 00:00:00

abstract：:Hruska et al. (1980) reported that hypophysectomy prevented the onset of dopamine receptor supersensitivity. We have repeated this investigation administering haloperidol (0.75 mg/day) or sulpiride (2 X 15 mg/day) or saline for 17 days, followed by a 3 day drug washout period, to sham-operated or hypophysectomised rat...

journal_title：European journal of pharmacology

authors： Jenner P,Rupniak NM,Hall MD,Dyer R,Leigh N,Marsden CD

更新日期：1981-11-19 00:00:00

abstract：:Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Once trained, the rats were tested with the ED50 of apomorphine (0.02 mg/kg) or saline before and 1-22 days after a ten-day regimen of daily 2.0 mg/kg admi...

journal_title：European journal of pharmacology

authors： Schechter MD

更新日期：1981-09-24 00:00:00

abstract：:The pharmacology of neurogenic trigeminovascular vasodilator responses in the dura mater is of interest for understanding the pathophysiology of migraine and to develop new therapies for this disabling common condition. Aminergic mechanisms have been implicated in migraine through direct study of amines in patients, a...

journal_title：European journal of pharmacology

authors： Akerman S,Williamson DJ,Hill RG,Goadsby PJ

更新日期：2001-07-13 00:00:00

abstract：:The effects of FG5893 were evaluated by several different methods; rats were used as experimental animals. Receptor binding studies revealed that FG5893 (2-(4-(4,4-bis(4-fluorophenyl)butyl)-1-piperazinyl)-3-pyridinecarboxy lic acid methyl ester) binds with high affinity to both 5-HT1A (Ki = 0.7 nM) and 5-HT2A receptor...

journal_title：European journal of pharmacology

authors： Albinsson A,Björk A,Svartengren J,Klint T,Andersson G

更新日期：1994-08-22 00:00:00

abstract：:Cats were treated once daily for 35 days with flurazepam (FZP). Different groups received 2, 5 or 20 mg/kg per day. A fourth group was started at 20 mg/kg per day, then the dose was increased to 30, and finally 40 mg/kg per day. Muscle relaxation, ataxia, and other measures of neurological impairment were used to meas...

journal_title：European journal of pharmacology

authors： Rosenberg HC,Chiu TH

更新日期：1982-07-16 00:00:00

abstract：:We investigated the involvement of p160ROCK (a Rho-associated coiled coil-forming protein kinase), one of Rho kinases on superoxide anion production (O(2)(-) production), aggregation and adhesion of human polymorphonuclear leukocytes under physiological condition, using a selective p160ROCK inhibitor, (+)-(R)-trans-4-...

journal_title：European journal of pharmacology

authors： Kawaguchi A,Ohmori M,Harada K,Tsuruoka S,Sugimoto K,Fujimura A

更新日期：2000-09-08 00:00:00

abstract：:The present studies examined the relationship between the blockade of central alpha1-adrenoceptors, as measured by ex vivo binding of [3H]prazosin in the cerebral cortex and the inhibition of behavioral activation to a mildly novel environment (cage change). It was found that intraventricular (i.v.t.) terazosin, a sal...

journal_title：European journal of pharmacology

authors： Stone EA,Rosengarten H,Lin Y,Quartermain D

更新日期：2001-05-25 00:00:00

abstract：:The alpha 2-adrenoceptor antagonist, yohimbine, has been reported to protect hypoxic myocardium. Yohimbine has several other activities, including 5-HT receptor antagonism, at the concentrations at which protection was found. Therefore we designed a study to determine if yohimbine was protecting ischemic myocardium vi...

journal_title：European journal of pharmacology

authors： Sargent CA,Dzwonczyk S,Grover GJ

更新日期：1994-08-11 00:00:00