The effect of alpha 2-adrenoceptor antagonists in isolated globally ischemic rat hearts.

abstract：:Coagulopathy is the major cause of organ injury as well as a strong predictor of mortality in septic patients. Systemic inflammatory response and redox imbalance are regarded as the major causes of sepsis-induced coagulopathy. There is growing evidence that a vasodilator hydralazine has beneficial effects on heart fai...

journal_title：European journal of pharmacology

authors： Huang HC,Hsiao TS,Liao MH,Tsao CM,Shih CC,Wu CC

更新日期：2020-09-05 00:00:00

abstract：:Microdialysis of the substantia nigra pars reticulata in freely moving rats disclosed a steady release of dopamine and its metabolites which was greatly reduced after reserpine (4 mg/kg s.c.) and alpha-methyl-p-tyrosine (200 mg/kg i.p.) pretreatments. Local infusion of high K+ (100 mM) or L-3,4-dihydroxyphenylalanine ...

journal_title：European journal of pharmacology

authors： Biggs CS,Fowler LJ,Whitton PS,Starr MS

更新日期：1996-03-28 00:00:00

abstract：:In the present study the antagonism of fentanyl pharmacodynamics was studied in the mouse and the receptor populations mediating the analgesic and lethal effects of fentanyl were examined. Both 1 and 8 days following implantation (s.c.) of a 15 mg naltrexone pellet there was a significant shift to the right of the fen...

journal_title：European journal of pharmacology

authors： Jang Y,Yoburn BC

更新日期：1991-05-17 00:00:00

abstract：:We have investigated the effect of inhaled HOE 140, a novel bradykinin B2 receptor antagonist, against bradykinin- and vagal stimulation-induced airway microvascular leakage and bronchoconstriction in anesthetized guinea-pigs. Lung resistance was measured for 6 min after challenge, followed by measurement of extravasa...

journal_title：European journal of pharmacology

authors： Sakamoto T,Sun J,Barnes PJ,Chung KF

更新日期：1994-01-14 00:00:00

abstract：:3,5-Dihydroxyphenylglycine (DHPG), (S)-3-hydroxyphenylglycine and (S)-4-carboxy-3-hydroxyphenylglycine (S-4C3HPG) stimulated phosphoinositide hydrolysis in neonatal rat cortical slices, but with lower maximal effect, in comparison with 2S,1'S,2'S-2-(2'-carboxycyclopropyl)glycine (L-CCG I) or (1S,3R)-1-aminocyclo-penta...

journal_title：European journal of pharmacology

authors： Schaffhauser H,de Barry J,Muller H,Heitz MP,Gombos G,Mutel V

更新日期：1997-09-10 00:00:00

abstract：:We investigated the effects of acute p.o. pretraining treatment with an indirect acetylcholinesterase inhibitor, metrifonate, on water maze spatial navigation and passive avoidance behavior. Metrifonate (10-100 mg/kg, orally, p.o.) did not improve the water maze or passive avoidance performance of young intact rats. H...

journal_title：European journal of pharmacology

authors： Riekkinen P Jr,Schmidt B,Stefanski R,Kuitunen J,Riekkinen M

更新日期：1996-08-08 00:00:00

abstract：:Corticotropin-releasing factor (CRF) regulates the hypothalamic-pituitary-adrenal axis, coordinates the mammalian stress response, and acting primarily via the CRF(1) receptor, has been strongly implicated in the pathophysiology of depression and anxiety. Furthermore, the behavioral and autonomic activation that occur...

journal_title：European journal of pharmacology

authors： Skelton KH,Oren D,Gutman DA,Easterling K,Holtzman SG,Nemeroff CB,Owens MJ

更新日期：2007-09-24 00:00:00

abstract：:Chemotherapy-induced neuropathies are widespread disorders evoked by characteristic damage of the nervous system. Sensory alterations, as paresthesia and dysesthesia, and severe pain are disabling side effects that altered quality of life, leading to therapy discontinuation. These kind of neuropathies are extremely di...

journal_title：European journal of pharmacology

authors： Di Cesare Mannelli L,Zanardelli M,Ghelardini C

更新日期：2013-07-05 00:00:00

abstract：:The family of facilitative glucose transporter (GLUT) proteins is responsible for the entry of glucose into cells throughout the periphery and the brain. The expression, regulation and activity of GLUTs play an essential role in neuronal homeostasis, since glucose represents the primary energy source for the brain. Br...

journal_title：European journal of pharmacology

authors： McEwen BS,Reagan LP

更新日期：2004-04-19 00:00:00

abstract：:MK-801 (a potent non-competitive antagonist of N-methyl-D-aspartic acid-mediated events) in subcutaneous doses of 0.1 and 0.2 mg/kg increased the threshold for electroconvulsions and in doses of 0.0031 and 0.0125 mg/kg enhanced the protective activity of valproate against maximal electroshock-induced convulsions in mi...

journal_title：European journal of pharmacology

authors： Urbańska E,Dziki M,Kleinrok Z,Czuczwar SJ,Turski WA

更新日期：1991-08-06 00:00:00

abstract：:The effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a thromboxane A2 synthase inhibitor, on eosinophil accumulation and activation were investigated in an experimental asthmatic guinea pig model and several cellular models. In the in vivo studies, CS-518 inhibited the bip...

journal_title：European journal of pharmacology

authors： Itoh K,Mukaiyama O,Satoh Y,Yamaguchi T,Iizuka Y

更新日期：1993-08-03 00:00:00

abstract：:Oxidative stress plays an important role in inflammatory process of celiac disease. We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in associa...

journal_title：European journal of pharmacology

authors： De Stefano D,Maiuri MC,Simeon V,Grassia G,Soscia A,Cinelli MP,Carnuccio R

更新日期：2007-07-02 00:00:00

abstract：:Glucocorticoids can reverse hemodynamic disturbances and dependence on catecholamines in septic shock. The relevant beneficial mechanisms of steroids in septic shock are unknown, although inducible nitric oxide synthase could account for them. The aim of this study was to compare the effects of dexamethasone, a glucoc...

journal_title：European journal of pharmacology

authors： Mansart A,Bollaert PE,Levy B,Nicolas MB,Mallié JP

更新日期：2003-08-15 00:00:00

abstract：:Morphine-induced analgesia, and the development of morphine-induced tolerance and dependence was determined in mice which had drunk caffeinated water (1 mg/ml) for 14 days or in mice which had received (-)-N6-(phenylisopropyl)-adenosine (PIA) 1 mg/kg i.p. for 14 days. Analgesia was assessed by the tail flick assay. Th...

journal_title：European journal of pharmacology

authors： Ahlijanian MK,Takemori AE

更新日期：1986-01-14 00:00:00

abstract：:Depression is a serious mental disorder that is becoming more common. To better treat patients suffering from this illness, elucidation of the underlying psychopathological and neurobiological mechanisms of depression is needed. Based on the evidence, we sought to investigate the effects of hesperidin in a model of de...

journal_title：European journal of pharmacology

authors： Antunes MS,Jesse CR,Ruff JR,de Oliveira Espinosa D,Gomes NS,Altvater EET,Donato F,Giacomeli R,Boeira SP

更新日期：2016-10-15 00:00:00

abstract：:Substance P and its tachykinin NK(1) receptors are highly expressed in brain regions involved in emotional control. We recently showed that NK(1)-mediated substance P neurotransmission is deeply involved in the control of aggressiveness. To get further insights into the NK(1) receptor/aggression relationship, we studi...

journal_title：European journal of pharmacology

authors： Halasz J,Zelena D,Toth M,Tulogdi A,Mikics E,Haller J

更新日期：2009-06-02 00:00:00

abstract：:Choline displaced [3H]QNB binding from rat brain muscarinic receptors competitively, (Ki = 460 microM) but it was only 1/1000th as potent as ACh. Deanol was an extremely weak displacer of [3H]QNB binding while hemicholinium-3 was 50 times more potent than choline. Although brain levels of choline are well below its Ki...

journal_title：European journal of pharmacology

authors： Speth RC,Yamamura HI

更新日期：1979-09-15 00:00:00

abstract：:In the rat substantia nigra Type II benzodiazepine recognition sites (measured as the portion of [3H]flunitrazepam binding which remain after the addition of 2 X 10(-7) M Cl 218872) represent 50% of the total benzodiazepine recognition sites. The density of Type II sites was increased by 35% following the degeneration...

journal_title：European journal of pharmacology

authors： Porceddu ML,Corda MG,Sanna E,Biggio G

更新日期：1985-06-07 00:00:00

abstract：:Identification of immunosuppressants from natural sources has a proven track record in immune mediated disorders. Pseudolaric acid B is a diterpenoid isolated from the roots of Pseudolarix amabilis, possessing potent immunomodulatory effect. However, the cytotoxicity limits its future clinical application. The purpose...

journal_title：European journal of pharmacology

authors： Li T,Chen H,Yang Z,Wang W,Wang YT,Zhang LM,Zhao JH,Zhou X,Li YM

更新日期：2014-12-15 00:00:00

abstract：:Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially inhibit the activity of inducible nitric oxide (NO) synthase with little inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vivo studies to examine its possible appl...

journal_title：European journal of pharmacology

authors： Hattori R,Inoue R,Sase K,Eizawa H,Kosuga K,Aoyama T,Masayasu H,Kawai C,Sasayama S,Yui Y

更新日期：1994-04-15 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor system is thought to be underactive in schizophrenia which may contribute to attentional dysfunction in this disease. In a visual signal detection task that required discrimination of signaled-trials from trials with no signal, the NMDA receptor antagonist, dizocilpine (0.05 mg...

journal_title：European journal of pharmacology

authors： Howe WM,Burk JA

更新日期：2007-12-22 00:00:00

abstract：:Brain microvessel endothelial cell monolayers have been shown to be a suitable blood-brain barrier in vitro system to study adrenergic regulation of permeability. We tested adrenergic drugs on bovine brain microvessel endothelial cell monolayer permeability to a biomembrane impermeant molecule, sodium fluorescein. End...

journal_title：European journal of pharmacology

authors： Borges N,Shi F,Azevedo I,Audus KL

更新日期：1994-10-14 00:00:00

abstract：:Meperidine has atypical opioid receptor agonist effects and shares some structural features with the phenyltropane (WIN) analogs of cocaine. In combination with 0.1 mg/kg naltrexone, meperidine produced cocaine-like discriminative stimulus effects in monkeys, whereas morphine was inactive. Both cocaine and meperidine ...

journal_title：European journal of pharmacology

authors： Izenwasser S,Newman AH,Cox BM,Katz JL

更新日期：1996-02-15 00:00:00

abstract：:Adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, adenine and inosine were injected intradermally into the backs of human volunteers. ATP, ADP and AMP evoked weal and flare responses in the skin in a dose dependent manner. The rank order of potency was ATP greater tha...

journal_title：European journal of pharmacology

authors： Coutts AA,Jorizzo JL,Eady RA,Greaves MW,Burnstock G

更新日期：1981-12-17 00:00:00

abstract：:Atherosclerosis is a leading cause of death worldwide. It is a complex chronic inflammatory disease involving interactions between vascular, circulating and immune cells. B cells play an important role in chronic inflammation producing antibodies and regulating T and natural killer (NKT) cell activation. The role of B...

journal_title：European journal of pharmacology

authors： Nus M,Tsiantoulas D,Mallat Z

更新日期：2017-12-05 00:00:00

abstract：:Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [3H]quaternised ICS 205-930 to 5-HT3 receptor sites in rat cortical membranes, possessing a pKi value of 7.0. In contrast, several other antipsychotic agents, including fluphe...

journal_title：European journal of pharmacology

authors： Watling KJ,Beer MS,Stanton JA,Newberry NR

更新日期：1990-07-17 00:00:00

abstract：:The antagonist potencies of SCH 23390 and domperidone have been determined at vascular and neuronal dopamine receptors in the rabbit isolated splenic artery and rectococcygeus muscle, respectively. SCH 23390 was a potent, competitive antagonist at vascular (pA2 = 10.65) but not neuronal (pA2 less than 6.0) receptors. ...

journal_title：European journal of pharmacology

authors： Hilditch A,Drew GM

更新日期：1985-10-08 00:00:00

abstract：:The Cl(-) channel blockers, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) or 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS) dose-dependently protected against oxygen-glucose deprivation in cultured rat cortical neurons. DIDS or SITS attenuated oxygen-glucose deprivation-induced increases...

journal_title：European journal of pharmacology

authors： Tauskela JS,Mealing G,Comas T,Brunette E,Monette R,Small DL,Morley P

更新日期：2003-03-07 00:00:00

abstract：:The effect of two serotonin precursors, 5-hydroxytryptophan (5-OH-TRP) and indolepyruvic acid (IPA), a tryptophan ketoanalogue, on rat pineal indole metabolism during the light-dark cycle was investigated. 5-OH-TRP drastically increased the production of 5-hydroxyindoleacetic acid at a dose of only 10 mg/kg, whereas 5...

journal_title：European journal of pharmacology

authors： Ferretti C,Blengio M,Ghi P,Genazzani E

更新日期：1990-10-23 00:00:00

abstract：:Oxidative stress has been implicated in the pathogenesis of acute myocarditis. The imbalance between the occurrence of reactive oxygen species and the cellular antioxidant defense mechanism plays a key role in myocardial injury of viral myocarditis. Carvedilol, a nonselective beta-adrenoceptor antagonist with addition...

journal_title：European journal of pharmacology

authors： Li YC,Ge LS,Yang PL,Tang JF,Lin JF,Chen P,Guan XQ

更新日期：2010-08-25 00:00:00