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Blocking effect of serotonin on beta-adrenoceptor activity in follicle-enclosed Xenopus oocytes.

Abstract：

:The effects of serotonin (5-HT) on a beta-adrenergic response were studied, using the voltage clamp technique, in Xenopus laevis oocytes surrounded by their follicular cells. noradrenaline induced marked hyperpolarization, with a specific increase in the permeability of the membrane toward K+. Application of 10 microM 5-HT had little effect on the resting membrane, but significantly depressed the response to 0.1 microM noradrenaline. The dose-response curve for noradrenaline showed a parallel shift to the right in the presence of 5-HT, suggesting that 5-HT competes with noradrenaline for common binding sites at the beta-adrenoceptor.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Fujita R,Tamazawa Y,Barnard EA,Matsumoto M

doi

10.1016/0014-2999(93)90901-s

subject

Has Abstract

pub_date

1993-08-24 00:00:00

pages

213-7

issue

2-3

eissn

0014-2999

issn

1879-0712

pii

0014-2999(93)90901-S

journal_volume

240

pub_type

杂志文章

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