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Iron overload-induced rat liver injury: Involvement of protein tyrosine nitration and the effect of baicalin.

Abstract：

:Baicalin has been reported to protect against liver injury in iron-overload mice, however, the mechanisms underlying the hepatoprotective properties of baicalin are poorly understood. In this study, we systematically studied the protective effect of baicalin on iron overload induced liver injury, as well as the underlying mechanism based on nitrative stress in rat model. We found that when iron overload rats (500mgiron/kg) were fed baicalin-containing diet (0.3% and 1% w/w) for 45days, baicalin dose dependently protected against iron overload induced liver injury, including alleviation of hepatic pathological damage, decrease of SOD activity, iron content, carbonyl content, and the thiobarbituric acid-reactive substances level in hepatic tissues. It also increased serum iron content, SH content and GPx activity, decreased serum ALT and AST activities. Immunohistochemistry and immunoprecipitation analysis revealed that baicalin could also inhibit iron overload induced protein tyrosine nitration in liver. Moreover, in iron overload rat liver, we found that baicalin decreased the iron overload increased level of glutathione-S-transferases (GSTs) expression, oxidation and nitration. These results suggest that not only oxidative stress, but also nitrative stress, is involved in iron overload induced liver injury, and the underlying mechanism might partially relate to the involvement of GSTs expression and post-translational modification. Baicalin can effectively prevent iron overload caused abnormality and can be a candidate medicine for iron overload diseases.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Zhang Y,Huang Y,Deng X,Xu Y,Gao Z,Li H

doi

10.1016/j.ejphar.2012.01.010

subject

Has Abstract

pub_date

2012-04-05 00:00:00

pages

95-101

issue

1-3

eissn

0014-2999

issn

1879-0712

pii

S0014-2999(12)00061-1

journal_volume

680

pub_type

杂志文章

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