Ethacrynic acid-induced convulsions and brain neurotransmitters in mice.

abstract：:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium diss...

journal_title：European journal of pharmacology

authors： Dickinson KE,Nahorski SR

更新日期：1981-08-27 00:00:00

abstract：:The effects of escins Ib and IIb isolated from horse chestnuts on Mg(2+) absorption from the digestive tract and the role of endogenous nitric oxide (NO) were investigated in mice. Test samples were given orally to fasted mice 30, 120, 180, 240 and 300 min before administration of 0.5 M MgSO(4) (10 ml/kg, p.o.). The s...

journal_title：European journal of pharmacology

authors： Li Y,Matsuda H,Wen S,Yamahara J,Yoshikawa M

更新日期：2000-01-17 00:00:00

abstract：:(5R)-5-hydroxytriptolide (LLDT-8) exhibits strong immunosuppressive activities in vitro and in vivo. Here, we investigated the effects of LLDT-8 on concanavalin A-induced hepatitis. Liver damage was evaluated by serum alanine transaminase (ALT) level and liver histology. The effects of LLDT-8 were determined by measur...

journal_title：European journal of pharmacology

authors： Zhou R,Tang W,Ren YX,He PL,Yang YF,Li YC,Zuo JP

更新日期：2006-05-10 00:00:00

abstract：:A number of neurosteroids exert antiseizure and/or neuroprotective properties. The aim of this study was to evaluate the effect of the neurosteroid alphaxalone on the protective action of conventional antiepileptics in four seizure tests. Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-...

journal_title：European journal of pharmacology

authors： Borowicz KK,Zadrozniak M,Swiader M,Kowalska A,Kleinrok Z,Czuczwar SJ

更新日期：2002-08-02 00:00:00

abstract：:In the present study, we describe the role of inositol trisphosphate in the signalling pathway that leads to the elevation of cytosolic-free Ca2+ in rat neutrophils stimulated with magnolol, a compound isolated from the cortex of Magnolia officinalis. Magnolol increased [Ca2+]i, by stimulating Ca2+ release from intern...

journal_title：European journal of pharmacology

authors： Wang JP,Chen CC

更新日期：1998-07-10 00:00:00

abstract：:It has been shown that G-protein coupled receptors have seven transmembrane alpha-helices, but the structural changes occurring in a G-protein coupled receptor as a response on agonist stimulus and the molecular events leading to blockade of the signal transduction by antagonists are not well understood. In the presen...

journal_title：European journal of pharmacology

authors： Sylte I,Bronowska A,Dahl SG

更新日期：2001-03-23 00:00:00

abstract：:DAA-I (des-aspartate-angiotensin I), an endogenous angiotensin, had been shown earlier to ameliorate animal models of cardiovascular diseases via the angiotensin AT1 receptor and prostaglandins. The present study investigated further the action of DAA-I on the release of PGE2, PGI2, PGF2α and TXA2 in HUVEC. 10(-11)-10...

journal_title：European journal of pharmacology

authors： Wen Q,Lee KO,Sim SZ,Xu XG,Sim MK

更新日期：2015-12-05 00:00:00

abstract：:The release of newly synthesised [3H]acetylcholine was evoked by electrical field stimulation (5 Hz, 600 pulses) of epithelium-deprived guinea-pig trachea strips after sensory neuropeptides depletion with 3 microM capsaicin. The selective tachykinin NK(2) receptor agonist [betaAla(8)]neurokinin A-(4-10) increased in a...

journal_title：European journal of pharmacology

authors： D'Agostino G,Erbelding D,Kilbinger H

更新日期：2000-05-12 00:00:00

abstract：:In vivo effects of histidine and carnosine against diabetic deterioration in diabetic Balb/cA mice were studied. Histidine and carnosine at 0.5, 1 g/l were added into drinking water. After 4 weeks intake of these agents, the content of histidine and carnosine in plasma, heart and liver significantly elevated (P < 0.05...

journal_title：European journal of pharmacology

authors： Lee YT,Hsu CC,Lin MH,Liu KS,Yin MC

更新日期：2005-04-18 00:00:00

abstract：:Possible changes in noradrenergic function were investigated in rat frontal cerebral cortex after acute treatment (1, 2 h) with the GABAB agonist, baclofen. A single i.p. injection of d,l-baclofen 10 mg/kg both reduced noradrenaline (NA) biosynthesis in vivo (31%) and the endogenous concentration of normetanephrine (N...

journal_title：European journal of pharmacology

authors： Losada ME

更新日期：1991-05-02 00:00:00

abstract：:Topoisomerase I (Top1) is the specific target of the anticancer drug camptothecin (CPT) that interferes with enzyme activity promoting Top1-mediated DNA breaks and inhibition of DNA and RNA synthesis. To define the specific transcriptional response to CPT, we have determined the CPT-altered transcription profiles in y...

journal_title：European journal of pharmacology

authors： Lotito L,Russo A,Bueno S,Chillemi G,Fogli MV,Capranico G

更新日期：2009-01-28 00:00:00

abstract：:Recent data show that corticolimbic expression of the effector immediate early gene Arc is up-regulated by standard antidepressant drugs. Here, we tested the effect upon Arc expression of a novel antidepressant and selective 5-hydroxytryptamine/noradrenaline reuptake inhibitor (SNRI), (-)1-(1-dimethylaminomethyl) 5-me...

journal_title：European journal of pharmacology

authors： Pei Q,Sprakes M,Millan MJ,Rochat C,Sharp T

更新日期：2004-04-12 00:00:00

abstract：:Melanocortin peptides have been shown to produce neuroprotection in experimental ischemic stroke. The aim of the present investigation was to identify the therapeutic treatment window of melanocortins, and to determine whether these neuropeptides chronically protect against damage consequent to brain ischemia. A 10-mi...

journal_title：European journal of pharmacology

authors： Giuliani D,Leone S,Mioni C,Bazzani C,Zaffe D,Botticelli AR,Altavilla D,Galantucci M,Minutoli L,Bitto A,Squadrito F,Guarini S

更新日期：2006-05-24 00:00:00

abstract：:To examine the mechanisms of tolcapone in the central nervous system (CNS), we analyzed alterations in parameters of striatal dopamine transmission induced by this drug (30 mg/kg) co-administered with the selective dopamine uptake inhibitor, GBR 12909 (10 mg/kg). Using microdialysis in freely moving rats, it was deter...

journal_title：European journal of pharmacology

authors： Budygin EA,Gainetdinov RR,Kilpatrick MR,Rayevsky KS,Männistö PT,Wightman RM

更新日期：1999-04-09 00:00:00

abstract：:In rats, surgical injury of the neocortex enhances the level of procholecystokinin-mRNA in the ipsilateral cortex. This increase in procholecystokinin gene expression was significantly reduced by the blockers of catecholamine re-uptake nomifensine (4 mg/kg), cocaine (5 mg/kg) and (+)-oxaprotiline (1.5 mg/kg) given i.m...

journal_title：European journal of pharmacology

authors： Mondeh JD,Olenik C,Götz E,Uhl A,Meyer DK

更新日期：1993-08-10 00:00:00

abstract：:Carbamazepine moderately depressed the input fiber volley resulting in attenuation of the dendritic epsp and the population spike in CA1 of rat hippocampal slices with a threshold concentration of 20 microM. The depressant effect on the population spike was not antagonized by the adenosine receptor blocker caffeine. P...

journal_title：European journal of pharmacology

authors： Olpe HR,Baudry M,Jones RS

更新日期：1985-03-26 00:00:00

abstract：:The inhibitory actions of the Ca2+ antagonist Cd2+, morphine and noradrenaline (exogenously added + endogenously released) on electrically evoked release of [3H]noradrenaline from superfused rat neocortical slices were strongly reduced when release was enhanced by 4-aminopyridine. In the presence of 4-aminopyridine th...

journal_title：European journal of pharmacology

authors： Schoffelmeer AN,Mulder AH

更新日期：1983-03-04 00:00:00

abstract：:Some antidepressants, as well as antiepileptics, are effective for treating pain of varying etiology. The present study was designed to characterize the antinociceptive effects of imipramine, a tricyclic antidepressant, fluvoxamine, a selective serotonin reuptake inhibitor, milnacipran, a serotonin noradrenaline reupt...

journal_title：European journal of pharmacology

authors： Aoki M,Tsuji M,Takeda H,Harada Y,Nohara J,Matsumiya T,Chiba H

更新日期：2006-11-21 00:00:00

abstract：:An excess of lipids may accumulate in the kidney in conditions such as diabetes and hypertension, and can potentially cause renal injury. We previously reported that an infusion of angiotensin II into a rat induced deposition of lipids in the renal tubular epithelial cells. Here we have examined the effect of pioglita...

journal_title：European journal of pharmacology

authors： Sakamoto A,Hongo M,Saito K,Nagai R,Ishizaka N

更新日期：2012-05-05 00:00:00

abstract：:Hypoglycemia developed in fasted rats during forced swimming. This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by an...

journal_title：European journal of pharmacology

authors： Yajima M,Hosokawa T,Ui M

更新日期：1977-03-07 00:00:00

abstract：:20(S)-Protopanaxadiol (PPD), a metabolite of ginsenosides, has been demonstrated to possess cytotoxic effects on several cancer cell lines. The molecular mechanism is, however, not well understood. In this study, we have shown that PPD inhibits cell growth and induces apoptosis in human hepatocarcinoma HepG2 cells. PP...

journal_title：European journal of pharmacology

authors： Zhu GY,Li YW,Tse AK,Hau DK,Leung CH,Yu ZL,Fong WF

更新日期：2011-10-01 00:00:00

abstract：:In pithed rats, we studied the effects of prostaglandin E2 and of subtype-selective prostaglandin E receptor (EP receptor) ligands on the rise in blood pressure induced by electrical stimulation of the preganglionic sympathetic nerves. Prostaglandin E2, the EP1/EP3 receptor agonist sulprostone and the EP2/EP3 receptor...

journal_title：European journal of pharmacology

authors： Malinowska B,Godlewski G,Buczko W,Schlicker E

更新日期：1994-07-11 00:00:00

abstract：:Subplantar injection of 0.10 micrograms of serotonin in the rat resulted in a brief period (0-20 min) of increased pain sensitivity to an applied force (hyperalgesia) which preceded a longer period (40-120 min) of decreased pain sensitivity (hypoalgesia). The magnitude of each of these changes and the duration of the ...

journal_title：European journal of pharmacology

authors： Vinegar R,Truax JF,Selph JL,Johnston PR

更新日期：1989-05-30 00:00:00

abstract：:In the brains of normal and reserpinized rats both diazepam and amino-oxyacetic acid (AOAA) decreased the 5-hydroxytryptophan (5HTP) accumulation induced by the decarboxylase inhibitor 3-hydroxybenzylhydrazine (NSD 1015). In reserpinized animals, the action of diazepam was antagonized by picrotoxin and bicuculline in ...

journal_title：European journal of pharmacology

authors： Saner A,Pletscher A

更新日期：1979-05-01 00:00:00

abstract：:Icariin is a major active component of the traditional herb Epimedium, also known as Horny Goat Weed. It has been extensively studied throughout the past several years and is known to exert anti-oxidative, anti-neuroinflammatory, and anti-apoptotic effects. It is now being considered as a potential therapeutic agent f...

journal_title：European journal of pharmacology

authors： Jin J,Wang H,Hua X,Chen D,Huang C,Chen Z

更新日期：2019-01-05 00:00:00

abstract：:We investigated intracellular Ca2+ regulation in pancreatic acinar cells from rats with diabetes induced by a single injection of streptozotocin (80 mg/kg). Experiments were performed 2 days and 7 days after the injection of streptozotocin. The density of muscarinic receptors, measured by [3H]N-methyl scopolamine bind...

journal_title：European journal of pharmacology

authors： Komabayashi T,Sawada H,Izawa T,Kogo H

更新日期：1996-03-18 00:00:00

abstract：:Schild plots for (-)-propranolol, timolol and IPS 339, but not penbutolol or carazolol, as antagonists of isoproterenol in the isolated, field-stimulated rat vas deferens exhibited biphasic curves indicating the presence of both high and low affinity sites for these agents in this preparation. Schild plots determined ...

journal_title：European journal of pharmacology

authors： Lotti VJ,Kling P,Cerino D

更新日期：1982-10-22 00:00:00

abstract：:Recombinant vaccinia viruses harboring the human dopamine D4 receptor cDNA containing two 48 base pair-repeats (D4.2) or the rat dopamine D2 short (D2s) receptor cDNA were used to infect rat-1 fibroblasts. Heterologous expression of both dopamine receptors was demonstrated in binding assays. The affinity constants of ...

journal_title：European journal of pharmacology

authors： Bouvier C,Bunzow JR,Guan HC,Unteutsch A,Civelli O,Grandy DK,Van Tol HH

更新日期：1995-06-23 00:00:00

abstract：:The adenosine A(2A) receptor in the basal ganglia is involved in the control of movement and plays a role in movement disorders such as Parkinsonism. Developing ligands to evaluate that receptor by noninvasive methods such as positron emission tomography has a high priority. In vitro radioligand binding guides the sel...

journal_title：European journal of pharmacology

authors： Sihver W,Schulze A,Wutz W,Stüsgen S,Olsson RA,Bier D,Holschbach MH

更新日期：2009-08-15 00:00:00

abstract：:Three naturally occurring peptides, pGlu-Glu-Pro amide, pGlu-Phe-Pro amide and pGlu-Gln-Pro amide, with similar structures to thyrotropin releasing hormone (TRH) have recently been identified but no studies of their in vivo activities have been reported previously. We describe here the ability of pGlu-Phe-Pro amide an...

journal_title：European journal of pharmacology

authors： Cremades A,Peñafiel R,Rausell V,Del Rio-Garcia J,Smyth DG

更新日期：1998-09-25 00:00:00