Abstract：
:The characteristics of beta-adrenoceptors on frog and chick erythrocytes have been compared to those present on rat erythrocyte, lung and cerebral cortical membranes. The receptors have been examined using the specific ligand [3H]dihydroalprenolol ([3H]DHA) with conventional filtration techniques. The equilibrium dissociation constant (KD) of [3H]DHA and the affinities of the non-selective beta-adrenoceptor antagonists propranolol, timolol and alprenolol, were very similar in all preparations examined. The relative order of potency of the catecholamines, isoprenaline greater than adrenaline greater than noradrenaline in rat lung, rat erythrocyte and frog erythrocyte; isoprenaline greater than noradrenaline greater than or equal to adrenaline in chick erythrocyte and rat cortex, suggest an overall beta 2-classification for the former and beta 1-classification of the latter tissues. However, the use of highly selective beta 1- or beta 2-agents and computer-assisted iterative curve fitting revealed that whereas rat cortex and lung possess both receptor subtypes (lung 80% beta 2, 20% beta 1: cortex 65% beta 1, 35% beta 2) only beta 2-sites were observed in rat erythrocytes. On the other hand, chick and frog erythrocytes possess a homogeneous population of receptors that do not strictly correspond either to beta 1- or beta 2-adrenoceptors. The atypical nature of these non-mammalian erythrocyte beta-adrenoceptors is discussed in relation to their previous extensive use as model beta-adrenoceptor systems.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Dickinson KE,Nahorski SRdoi
10.1016/0014-2999(81)90321-6subject
Has Abstractpub_date
1981-08-27 00:00:00pages
43-52issue
1eissn
0014-2999issn
1879-0712pii
0014-2999(81)90321-6journal_volume
74pub_type
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(93)90013-8
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/s0014-2999(01)01019-6
更新日期：2001-05-18 00:00:00
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journal_title：European journal of pharmacology
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doi：10.1016/0014-2999(95)00638-9
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(93)90964-j
更新日期：1993-04-06 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(79)90503-x
更新日期：1979-08-15 00:00:00
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journal_title：European journal of pharmacology
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更新日期：2019-07-05 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章,评审
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更新日期：2001-01-19 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1991-07-23 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2004.05.047
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(89)90512-8
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(90)90165-3
更新日期：1990-04-25 00:00:00
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journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/j.ejphar.2005.01.016
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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journal_title：European journal of pharmacology
pub_type： 杂志文章
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更新日期：1988-08-24 00:00:00
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journal_title：European journal of pharmacology
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更新日期：1998-03-19 00:00:00
abstract：:Previous studies have shown that chronic treatment with antidepressants (AD) leads to an increased responsiveness of NA systems to noradrenaline (NA) or its agonist. In the present paper the influence is described of a prolonged treatment with AD of different pharmacological profiles on the effect of reserpine in the ...
journal_title：European journal of pharmacology
pub_type： 杂志文章
doi：10.1016/0014-2999(83)90087-0
更新日期：1983-03-04 00:00:00
