Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.

abstract：:Ten beta-adrenoceptor blocking drugs varying in lipophilicity and beta-adrenoceptor blocking potency were examined for inhibitory effects on synaptosomal [3H]noradrenaline uptake. All compounds produced a concentration-dependent inhibition of noradrenaline uptake, but were at least one order of magnitude less potent t...

journal_title：European journal of pharmacology

authors： Street JA,Walsh A

更新日期：1984-07-13 00:00:00

abstract：:Serotonergic and dopaminergic involvement in hyperthermia induced by a serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine, was investigated in mice. Neither the 5-HT transporter inhibitor fluoxetine nor the 5-HT depleter p-chlorophenylalanine affected p-chloroamphetamine-induced hyperthermia. Th...

journal_title：European journal of pharmacology

authors： Sugimoto Y,Ohkura M,Inoue K,Yamada J

更新日期：2001-11-02 00:00:00

abstract：:Corticotropin releasing factor (CRF) is a hypothalamic hormone that also displays autocrine/paracrine roles at peripheral sites. High concentrations of CRF have been identified in endothelial cells and other inflammatory tissues. We investigated the effects of CRF and antagonists in the regulation of prostaglandin syn...

journal_title：European journal of pharmacology

authors： Fleisher-Berkovich S,Rimon G,Danon A

更新日期：1998-07-24 00:00:00

abstract：:The effect of noradrenaline on 5-hydroxytryptamine (5-HT) release from isolated mouse ileal tissues was investigated. Noradrenaline, but not isoprenaline, at 1 microM stimulated 5-HT release, an effect which was inhibited by yohimbine, an alpha(2)-adrenoceptor antagonist, but not by bunazosin, an alpha(1)-adrenoceptor...

journal_title：European journal of pharmacology

authors： Hirafuji M,Ogawa T,Kato K,Hamaue N,Endo T,Parvez H,Minami M

更新日期：2001-12-07 00:00:00

abstract：:Disulfiram (700 mg/kg, p.o.) significantly increased the brain levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in rats. Ethanol (1 g/kg and 2 x 1.5 g/kg, i.p.) did not affect the 5-HT level, but at the higher dose it significantly increased the 5-HIAA level. When disulfiram was given in combination ...

journal_title：European journal of pharmacology

authors： Fukumori R,Minegishi A,Satoh T,Kitagawa H,Yanaura S

更新日期：1980-01-25 00:00:00

abstract：:The possible influence of several neuropeptides on muscarinic receptor binding and function in fronto-parietal cortex of young and senescent Fischer 344 rats was examined. Low concentrations (100 nM) of cholecystokinin, neurotensin and vasoactive intestinal polypeptide (VIP), added in vitro, enhanced carbachol-stimula...

journal_title：European journal of pharmacology

authors： Pedigo NW Jr,Rice MA

更新日期：1992-02-13 00:00:00

abstract：:The effect of vasoactive intestinal polypeptide (VIP) on in vitro ACTH release and adenylate cyclase activity was investigated in human ACTH-secreting pituitary adenomas from 4 patients with Cushing's disease and 2 patients with Nelson's syndrome. In all the tumors tested, VIP elicited a dose-dependent stimulation of ...

journal_title：European journal of pharmacology

authors： Oliva D,Nicosia S,Spada A,Giannattasio G

更新日期：1982-09-10 00:00:00

abstract：:The treatment of alcohol dependence mainly consists of psychological, social, and pharmacotherapeutic interventions aiming to reduce physical withdrawal, craving, and alcohol relapse. During the last years, it has become increasingly clear that adjuvant pharmacotherapy is efficacious especially in rehabilitation progr...

journal_title：European journal of pharmacology

authors： Kiefer F,Mann K

更新日期：2005-12-05 00:00:00

abstract：:A concentration-dependent relaxant effect of phentolamine was demonstrated in guinea-pig isolated trachea and was probably unrelated to its alpha-adrenoceptor blocking action. The maximal effect of phentolamine against spontaneous tracheal tone was in the 24-100% range. However, phentolamine produced 100% relaxation w...

journal_title：European journal of pharmacology

authors： Bang L,Nielsen-Kudsk JE

更新日期：1992-02-11 00:00:00

abstract：:Non-peptide antagonists of the NK1 and NK2 receptors were tested as inhibitors of the reaction time in the rat tail-flick and on the decrease of reaction time induced by the intrathecal injection of the NK1 receptor selective agonist [Sar9,Met(O2)11]SP or of the NK2 selective agonist NKA-(4-10). The decrease in reacti...

journal_title：European journal of pharmacology

authors： Picard P,Boucher S,Regoli D,Gitter BD,Howbert JJ,Couture R

更新日期：1993-03-02 00:00:00

abstract：:We examined the effect of HSR-81 ((-)-(R)-alpha-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol L-tartrate), a newly developed, potent and selective beta 2-adrenoceptor agonist, as well as ritodrine and isoproterenol, on the spontaneous rhythmic contraction in uteri isolated from late pregnant, middle pregn...

journal_title：European journal of pharmacology

authors： Ohashi T,Hashimoto S,Morikawa K,Kato H,Ito Y,Asano M,Azuma H

更新日期：1996-07-04 00:00:00

abstract：:This paper describes the pharmacological activity of D,L-(tetrazol-5-yl)glycine, a structurally novel and highly potent agonist at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. D,L-(Tetrazol-5-yl)glycine potently displaced NMDA receptor binding to rat brain membranes as measured using [3H]...

journal_title：European journal of pharmacology

authors： Schoepp DD,Smith CL,Lodge D,Millar JD,Leander JD,Sacaan AI,Lunn WH

更新日期：1991-10-15 00:00:00

abstract：:The ability of flunarizine to terminate ouabain-induced ventricular tachycardia was investigated in conscious dogs. These arrhythmias result from triggered activity based on delayed afterdepolarizations. Sustained ventricular tachycardia was induced by ouabain (48 +/- 6 micrograms/kg) and pacing in 13 animals with sur...

journal_title：European journal of pharmacology

authors： Vos MA,Gorgels AP,Drenth JP,Leunissen JD,Wellens HJ

更新日期：1989-06-08 00:00:00

abstract：:The leukotrienes are potent inflammatory mediators, which may have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowl disease and asthma. Zafirlukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. However, it is not known whether these leukotrienes are inv...

journal_title：European journal of pharmacology

authors： Jain NK,Kulkarni SK,Singh A

更新日期：2001-06-29 00:00:00

abstract：:Pirfenidone recently received FDA approval as one of the first two drugs designed to treat idiopathic pulmonary fibrosis. While the clinical data continues to support the efficacy of pirfenidone, the specific molecular mechanism of action of this drug has not been fully defined. From a chemical perspective the compara...

journal_title：European journal of pharmacology

authors： Haak AJ,Girtman MA,Ali MF,Carmona EM,Limper AH,Tschumperlin DJ

更新日期：2017-09-15 00:00:00

abstract：:The present experiments were designed to characterize the mechanisms involved in the corticotropin releasing factor (CRF)-induced activation of central sympatho-adrenomedullary outflow in rats. Intracerebroventricularly (i.c.v.) administered CRF and urocortin (0.5, 1.5 and 3.0 nmol/animal) effectively and dose-depende...

journal_title：European journal of pharmacology

authors： Yokotani K,Murakami Y,Okada S,Hirata M

更新日期：2001-05-11 00:00:00

abstract：:Ischemic preconditioning reduces post-ischemic myocardial injury by activating myocellular adenosine A1 receptors. Adenosine A3 receptors have also been implicated but there is no evidence for A3 receptors in cardiac myocytes. The aim of this study was to develop a model of preconditioning in isolated cardiac myocytes...

journal_title：European journal of pharmacology

authors： Wang J,Drake L,Sajjadi F,Firestein GS,Mullane KM,Bullough DA

更新日期：1997-02-12 00:00:00

abstract：:Nitric oxide synthases (NOS) and cyclooxygenase-2 (COX-2) are important enzymes involved in ulcer healing but interactions between them have not been clearly defined. The aim of this study was to investigate the effects of selective or non-selective inhibition of NOS on the expression and activity of COX-2 during heal...

journal_title：European journal of pharmacology

authors： Guo JS,Cho CH,Wang JY,Koo MW

更新日期：2006-05-01 00:00:00

abstract：:In voltage-clamp experiments with the myelinated nerve fibre of Xenopus laevis, 9-amino-1,2,3,4-tetrahydroacridine (THA) decreased both Na+ and K+ currents and shifted the steady state inactivation potential curve in a negative direction. The effects may be described as (a) a decrease of the permeability constant PNa,...

journal_title：European journal of pharmacology

authors： Elinder F,Mohammed AK,Winblad B,Arhem P

更新日期：1989-05-30 00:00:00

abstract：:The effect of KC 2450 (racemic 3,5-cis-3-methylamino-2,3,4,5-tetrahydro-1-benzoxepine-5-ol hydrochloride) on lower esophageal sphincter pressure in pentobarbital-anesthetized dogs was determined and compared to the effect of metoclopramide. The ED20 value (i.e. the dose that increased lower esophageal sphincter pressu...

journal_title：European journal of pharmacology

authors： Fowler PJ,Nelson AH,Price WJ,Sarau HM,Grous M,Lombardi DM,Barone FC,Ormsbee HS 3rd

更新日期：1987-10-13 00:00:00

abstract：:Iron-mediated oxidative stress has been recognized as one of the leading causes of chronic kidney injury. The effect of L-type calcium channel (LTCC) blocker on iron overload has been shown in cardiomyocytes, liver cells, and nerve cells. So far, few studies have examined whether blockers improve kidney iron-mediated ...

journal_title：European journal of pharmacology

authors： Sun L,Lin X,Pornprasert S,Lü X,Ran B,Lin Y

更新日期：2020-11-05 00:00:00

abstract：:A novel compound, FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writhing test (ED50 = 1.8 mg/kg p.o.), whereas it has little antinociceptive activity in the tai...

journal_title：European journal of pharmacology

authors： Ohkubo Y,Nomura K,Yamaguchi I

更新日期：1991-11-05 00:00:00

abstract：:The intracerebral injection technique was used to apply dopamine directly into dopamine-containing areas of the mesolimbic system, the nucleus accumbens septi, tuberculum olfactorium and nucleus amygdaloideus centralis. 200 mug dopamine injected bilaterally into the nucleus accumbens septi caused a stereotyped sniffin...

journal_title：European journal of pharmacology

authors： Costall B,Naylor RJ

更新日期：1975-05-01 00:00:00

abstract：:A cDNA clone which encodes a putative kainate receptor was prepared with the polymerase chain reaction; from this, 'antisense' RNA fragments were produced and used to evaluate the distribution of mRNA for the kainate-receptor in rat brain with in situ hybridization techniques. The data demonstrate marked regional diff...

journal_title：European journal of pharmacology

authors： Gall C,Sumikawa K,Lynch G

更新日期：1990-09-18 00:00:00

abstract：:The antithrombotic effect of desethyl KBT-3022, which is the main active metabolite of the new antiplatelet agent, KBT-3022 (ethyl 2-[4,5-bis(4-methoxyphenyl)thiazol-2-yl] pyrrol-1-ylacetate; a cyclooxygenase inhibitor), was determined using a photochemically induced arterial thrombosis model in the rat femoral artery...

journal_title：European journal of pharmacology

authors： Shimazawa M,Takiguchi Y,Umemura K,Kondo K,Nakashima M

更新日期：1997-06-11 00:00:00

abstract：:Peripheral type benzodiazepine receptors are differentially modified by arachidonate, diethylpyrocarbonate and thiol reagents, as evidenced by the finding that binding of a proposed agonist ([3H]R05-4864) and a proposed antagonist ([3H]PK 11195) to rat kidney mitochondrial membranes can be modified separately. (1) Ara...

journal_title：European journal of pharmacology

authors： Skowroński R,Beaumont K,Fanestil DD

更新日期：1987-11-17 00:00:00

abstract：:Dopamine (DA) was injected in the third brain ventricle of goats and the thermoregulatory effects were studied under different ambient conditions. The effects depended on dose, ambient conditions and cannula used. In the cold, there was a drop in body temperature, sometimes accompanied by suppression of shivering and ...

journal_title：European journal of pharmacology

authors： De Roij TA,Frens J,Bakker J,Németh F

更新日期：1977-05-01 00:00:00

abstract：:Although a number of studies have shown that perivascular adipose tissue (PVAT) attenuates arterial contraction through the release of perivascular-derived relaxation factors (PVRF), the role of PVAT in modulating venous function and its mechanism(s) remained unknown. Here we examined the role of PVAT in the modulatio...

journal_title：European journal of pharmacology

authors： Lu C,Zhao AX,Gao YJ,Lee RM

更新日期：2011-04-25 00:00:00

abstract：:A number of neurosteroids exert antiseizure and/or neuroprotective properties. The aim of this study was to evaluate the effect of the neurosteroid alphaxalone on the protective action of conventional antiepileptics in four seizure tests. Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-...

journal_title：European journal of pharmacology

authors： Borowicz KK,Zadrozniak M,Swiader M,Kowalska A,Kleinrok Z,Czuczwar SJ

更新日期：2002-08-02 00:00:00

abstract：:Pigs were subjected to acute, intermittent hypoxia (fraction of inhaled O2 0.1, n = 10). The increase in mean pulmonary artery pressure during hypoxia was not altered after i.v. administration of the selective endothelin ETB receptor antagonist BQ-788 (N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma-methylleucyl-D -1- me...

journal_title：European journal of pharmacology

authors： Holm P,Liska J,Franco-Cereceda A

更新日期：1997-03-26 00:00:00